Rv0003

Tuberculist information
Gene namerecF
Protein functionDNA replication and repair protein RecF (single-strand DNA binding protein)
Functional category(tuberculist)information pathways
Gene location(kb)3.28
Molecular mass(da)42180.2
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 385
	  		  	1    VYVRHLGLRDFRSWACVDLELHPGRTVFVGPNGYGKTNLIEALWYSTTLGSHRVSADLPL   60
			  	61   IRVGTDRAVISTIVVNDGRECAVDLEIATGRVNKARLNRSSVRSTRDVVGVLRAVLFAPE  120
			  	121  DLGLVRGDPADRRRYLDDLAIVRRPAIAAVRAEYERVLRQRTALLKSVPGARYRGDRGVF  180
			  	181  DTLEVWDSRLAEHGAELVAARIDLVNQLAPEVKKAYQLLAPESRSASIGYRASMDVTGPS  240
			  	241  EQSDIDRQLLAARLLAALAARRDAELERGVCLVGPHRDDLILRLGDQPAKGFASHGEAWS  300
			  	301  LAVALRLAAYQLLRVDGGEPVLLLDDVFAELDVMRRRALATAAESAEQVLVTAAVLEDIP  360
			  	361  AGWDARRVHIDVRADDTGSMSVVLP

Known structures in the PDB
No Known structures
1 39 77 115 153 191 229 267 305 343 381 Range: 2 to 359  |  Coverage: 92% SMC_N Range: 1 to 138  |  Coverage: 35% 1 Range: 1 to 205  |  Coverage: 52% 1
Number of amino acids : 385
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
SMC_NPF024632-359
Mtb Structural Proteome models
Model Number1
Model nameRv0003
Template1XEW    XPDBCREDO
Template coverage2_165
Template Identity(%)22.5
Model coverage(%)35.6
Normalized DOPE score-0.3

Structure Models from Chopin
Model Number1
Profilec.37.1.12 - 3.40.1140.10
Click for model details
zscore10.22
Residue begin1
Residue end205
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0003Gene nameConfidence Score
Rv0002dnaN0.999
Rv0002dnaN0.999
Rv0002dnaN0.999
Rv3715crecR0.997
Rv0005gyrB0.997
Rv0001dnaA0.997
Rv0005gyrB0.997
Rv0001dnaA0.997
Rv0005gyrB0.997
Rv0005gyrB0.997
Rv3715crecR0.997
Rv3715crecR0.997
Rv0006gyrA0.996
Rv0006gyrA0.996
Rv2362crecO0.981
Rv2362crecO0.981
Rv3924crpmH0.978
Rv2594cruvC0.97
Rv2593cruvA0.966
Rv2593cruvA0.966
Rv2592cruvB0.966
Rv2592cruvB0.966
Rv2593cruvA0.966
Rv1020mfd0.958
Rv1020mfd0.958
Rv1020mfd0.958
Rv1020mfd0.958
Rv0631crecC0.95
Rv0629crecD0.929
Rv0629crecD0.929
Rv0630crecB0.927
Rv0630crecB0.927
Rv0630crecB0.927
Rv1633uvrB0.926
Rv2720lexA0.926
Rv1633uvrB0.926
Rv2720lexA0.926
Rv1633uvrB0.926
Rv1633uvrB0.926
Rv0004Rv00040.92
Rv0054ssb0.919
Rv1547dnaE10.918
Rv1547dnaE10.918
Rv1547dnaE10.918
Rv1547dnaE10.918
Rv1638uvrA0.906
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
nalidixic acidPubChem0.723232.235