Rv0630c

Tuberculist information
Gene namerecB
Protein functionProbable exonuclease V (beta chain) RecB (exodeoxyribonuclease V beta chain)(exodeoxyribonuclease V polypeptide) (chi-specific endonuclease)
Functional category(tuberculist)information pathways
Gene location(kb)721.729
Molecular mass(da)118722
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 1094
	  		  	1    MDRFELLGPLPREGTTTVLEASAGTGKTFALAGLVTRYLAETAATLDEMLLITFNRAASR   60
			  	61   ELRERVRGQIVEAVGALQGDAPPSGELVEHLLRGSDAERAQKRSRLRDALANFDAATIAT  120
			  	121  THEFCGSVLKSLGVAGDNAADVELKESLTDLVTEIVDDRYLANFGRQETDPELTYAEALA  180
			  	181  LALAVVDDPCAQLRPPDPEPGSKAAVRLRFAAEVLEELERRKGRLRAQGFNDLLIRLATA  240
			  	241  LEAADSPARDRMRERWRIVLVDEFQDTDPMQWRVLERAFSRHSALILIGDPKQAIYGFRG  300
			  	301  GDIHTYLKAAGTADARYTLGVNWRSDRALVESLQTVLRDATLGHADIVVRGTDAHHAGHR  360
			  	361  LASAPRPAPFRLRVVKRHTLGYDGTAHVPIEALRRHIPDDLAADVAALLASGATFAGRPV  420
			  	421  VAADIAVIVEHHKDARACRNALAEAGIPAIYTGDTDVFASQAAKDWLCLLEAFDAPQRSG  480
			  	481  LVRAAACTMFFGETAESLAAEGDALTDRVAGTLREWADHARHRGVAAVFQAAQLAGMGRR  540
			  	541  VLSQRGGERDLTDLAHIAQLLHEAAHRERLGLPGLRDWLRRQAKAGAGPPEHNRRLDSDA  600
			  	601  AAVQIMTVFVAKGLQFPIVYLPFAFNRNVRSDDILLYHDDGTRCLYIGGKDGGAQRRTVE  660
			  	661  GLNRVEAAHDNLRLTYVALTRAQSQVVAWWAPTFDEVNGGLSRLLRGRRPGQSQVPDRCT  720
			  	721  PRVTDEQAWAVFAQWEAAGGPSVEESVIGARSSLEKPVPVPGFEVRHFHRRIDTTWRRTS  780
			  	781  YSDLVRGSEAVTVTSEPAAGGRADEVEIAVVAAPGSGADLTSPLAALPSGASFGSLVHAV  840
			  	841  LETADPAAPDLAAELEAQVRRHAPWWTVDVDHAQLAPELARALLPMHDTPLGPAAAALTL  900
			  	901  RQIGVRDRLRELDFEMPLAGGDLRGRSPDVSLADVGELLASHLPGDDPLSPYADRLGSAG  960
			  	961  LGDQPLRGYLAGSIDVVLRLPGQRYLVVDYKTNHLGDTAADYGFERLTEAMLHSDYPLQA 1020
			  	1021 LLYVVVLHRFLRWRQRDYAPARHLGGVLYLFVRGMCGAATPVTAGHPAGVFTWNPPTALV 1080
			  	1081 VALSDLLDRGRLQS

Known structures in the PDB
No Known structures
1 110 219 328 437 546 655 764 873 982 1091 Range: 5 to 314  |  Coverage: 28% UvrD-helicase Range: 317 to 693  |  Coverage: 34% UvrD_C Range: 814 to 1055  |  Coverage: 22% PDDEXK_1 Range: 2 to 085  |  Coverage: 7% 1 Range: 1 to 1089  |  Coverage: 99% 1 Range: 764 to 1089  |  Coverage: 29% 2 Range: 1 to 726  |  Coverage: 66% 3 Range: 452 to 613  |  Coverage: 14% 4 Range: 5 to 148  |  Coverage: 13% 5 Range: 152 to 230  |  Coverage: 7% 6
Number of amino acids : 1094
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
UvrD-helicasePF005805-314
UvrD_CPF13361317-693
PDDEXK_1PF12705814-1055
Mtb Structural Proteome models
Model Number1
Model nameRv0630c
Template1W36    BPDBCREDO
Template coverage3_1171
Template Identity(%)32.6
Model coverage(%)99.1
Normalized DOPE score0.72

Structure Models from Chopin
Model Number1
Profilec.37.1.19, c.52.1.24 - 1.10.3170.10, 1.10.486.10, 3.40.50.300, 3.90.320.10
Click for model details
zscore85.08
Residue begin1
Residue end1089
Model Number2
Profilec.52.1.13 - 3.90.320.10
Click for model details
zscore51.48
Residue begin764
Residue end1089
Model Number3
Profile1.10.10.160, 1.10.486.10, 3.40.50.300
Click for model details
zscore30.28
Residue begin1
Residue end726
Model Number4
Profile1.10.486.10
Click for model details
zscore13.79
Residue begin452
Residue end613
Model Number5
Profilec.37.1.14
Click for model details
zscore8.33
Residue begin5
Residue end148
Model Number6
Profile1.10.10.160
Click for model details
zscore7.62
Residue begin152
Residue end230
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0630cGene nameConfidence Score
Rv0629crecD0.999
Rv0629crecD0.999
Rv0631crecC0.999
Rv3715crecR0.947
Rv3715crecR0.947
Rv3715crecR0.947
Rv0003recF0.927
Rv2594cruvC0.926
Rv2592cruvB0.915
Rv2592cruvB0.915
Rv1696recN0.902
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
No high confidence interactions