Rv0631c

Tuberculist information
Gene namerecC
Protein functionProbable exonuclease V (gamma chain) RecC (exodeoxyribonuclease V gamma chain)(exodeoxyribonuclease V polypeptide)
Functional category(tuberculist)information pathways
Gene location(kb)725.013
Molecular mass(da)119501
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 1097
	  		  	1    MALHLHRAERTDLLADGLGALLADPQPDPFAQELVLVAARGVERWLSQRLSLVLGCGPGR   60
			  	61   ADGVCAGIAFRNPQSLIAEITGTLDDDPWSPEALAWPLLAVIDASLDEPWCRTLASHLGH  120
			  	121  FATTDAEAELRRGRRYSVARRLAGLFASYARQRPGLLAAWLDGDLGELPGDLAWQPPLWR  180
			  	181  ALVTTVGADPPHVRHDKTIARLRDGPADLPARLSLFGHTRLACTDVQLLDALAVHHDLHL  240
			  	241  WLPHPSDELWRALAGFQGADGLLPRRQDTSRRAAQHPLLETLGRDVRELQRALPAARATD  300
			  	301  EFLGATTKPDTLLGWLQADIAGNAPRPAGRSLSDADRSVQVHACHGPARQIDVLREVLLG  360
			  	361  LLEDDPTLQPRDIVVMCPDIDTYAPLIVAGFGLGEVAGDCHPAHRLRVRLADRALTQTNP  420
			  	421  LLSVAAELLTIAETRATASQLLNLAQAAPVRAKFGFADDDLDTITTWVRESNIRWGFDPT  480
			  	481  HRRRYGLDTVVHNTWRFGLDRILTGVAMSEDSQAWLDTALPLDDVGSNRVELAGRLAEFV  540
			  	541  ERLHHVVGGLSGARPLVAWLDALATGIDLLTACNDGWQRAQVQREFADVLARAGSRAAPL  600
			  	601  LRLPDVRALLDAQLAGRPTRANFRTGTLTVCTMVPMRSVPHRVVCLVGLDDGVFPRLSHP  660
			  	661  DGDDVLAREPMTGERDIRSEDRQLLLDAIGAATQTLVITYTGADERTGQPRPPAVPLAEL  720
			  	721  LDALDQTTSAPVRERILVTHPLQPFDRKNVTPGALLGAKPFTFDPAALAAAQAAAGKRCP  780
			  	781  PTAFISGRLPAPPAADVTLADLLDFFKDPVKGFFRALDYTLPWDVDTVEDSIPVQVDALA  840
			  	841  EWTVGERMLRDMLRGLHPDDAAHSEWRRGTLPPGRLGVRRAKEIRNRARDLAAAALAHRD  900
			  	901  GHGQAHDVDVDLGDGRRLSGTVTPVFGGRTVSVTYSKLAPKHVLPAWIGLVTLAAQEPGR  960
			  	961  EWSALCIGRSKTRNHIARRLFVPPPDPVAVLRELVLLYDAGRREPLPLPLKTSCAWAQAR 1020
			  	1021 RDGQDPYPPARECWQTNRFRPGDDDAPAHVRAWGPRAPFEVLLGKPRAGEEVAGEETRLG 1080
			  	1081 ALAARLWLPLLAAEGSV

Known structures in the PDB
No Known structures
1 110 219 328 437 546 655 764 873 982 1091 Range: 2 to 801  |  Coverage: 72% Exonuc_V_gamma Range: 3 to 094  |  Coverage: 8% 1 Range: 3 to 023  |  Coverage: 1% 2 Range: 783 to 1095  |  Coverage: 28% 1
Number of amino acids : 1097
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Exonuc_V_gammaPF042572-801
Mtb Structural Proteome models
Model Number1
Model nameRv0631c.1
Template1W36    CPDBCREDO
Template coverage2_1122
Template Identity(%)26.3
Model coverage(%)99.6
Normalized DOPE score0.233

Model Number2
Model nameRv0631c
Template1W36    CPDBCREDO
Template coverage2_1054
Template Identity(%)30.2
Model coverage(%)93.2
Normalized DOPE score0.431

Structure Models from Chopin
Model Number1
Profilec.52.1.25
Click for model details
zscore28.99
Residue begin783
Residue end1095
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0631cGene nameConfidence Score
Rv0629crecD0.999
Rv0629crecD0.999
Rv0630crecB0.999
Rv0630crecB0.999
Rv0630crecB0.999
Rv2592cruvB0.97
Rv2592cruvB0.97
Rv2593cruvA0.969
Rv2593cruvA0.969
Rv2593cruvA0.969
Rv2594cruvC0.961
Rv1696recN0.956
Rv0003recF0.95
Rv3715crecR0.934
Rv3715crecR0.934
Rv3715crecR0.934
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
No high confidence interactions