Rv2720

Tuberculist information
Gene namelexA
Protein functionRepressor LexA
Functional category(tuberculist)regulatory proteins
Gene location(kb)3031.79
Molecular mass(da)24841.2
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 236
	  		  	1    MNDSNDTSVAGGAAGADSRVLSADSALTERQRTILDVIRASVTSRGYPPSIREIGDAVGL   60
			  	61   TSTSSVAHQLRTLERKGYLRRDPNRPRAVNVRGADDAALPPVTEVAGSDALPEPTFVPVL  120
			  	121  GRIAAGGPILAEEAVEDVFPLPRELVGEGTLFLLKVIGDSMVEAAICDGDWVVVRQQNVA  180
			  	181  DNGDIVAAMIDGEATVKTFKRAGGQVWLMPHNPAFDPIPGNDATVLGKVVTVIRKV

Known structures in the PDB
No Known structures
1 24 47 70 93 116 139 162 185 208 231 Range: 24 to 88  |  Coverage: 27% LexA_DNA_bind Range: 155 to 223  |  Coverage: 28% Peptidase_S24 Range: 6 to 216  |  Coverage: 88% 1 Range: 6 to 216  |  Coverage: 88% 1 Range: 5 to 76  |  Coverage: 30% 2 Range: 111 to 217  |  Coverage: 44% 3
Number of amino acids : 236
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
LexA_DNA_bindPF0172624-88
Peptidase_S24PF00717155-223
Mtb Structural Proteome models
Model Number1
Model nameRv2720
Template1JHF    APDBCREDO
Template coverage2_198
Template Identity(%)35.0
Model coverage(%)96.8
Normalized DOPE score-0.335

Structure Models from Chopin
Model Number1
Profilea.4.5.2, b.87.1.1 - 1.10.10.10, 2.10.109.10
Click for model details
zscore37.24
Residue begin6
Residue end216
Model Number2
Profilea.4.5.2 - 1.10.10.10
Click for model details
zscore23.16
Residue begin5
Residue end76
Model Number3
Profileb.87.1.1 - 2.10.109.10
Click for model details
zscore15.42
Residue begin111
Residue end217
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2720Gene nameConfidence Score
Rv2737crecA0.997
Rv2737crecA0.997
Rv3370cdnaE20.99
Rv3370cdnaE20.99
Rv3370cdnaE20.99
Rv3370cdnaE20.99
Rv1633uvrB0.988
Rv1633uvrB0.988
Rv3056dinP0.988
Rv1633uvrB0.988
Rv3056dinP0.988
Rv1633uvrB0.988
Rv1696recN0.98
Rv3585radA0.973
Rv3585radA0.973
Rv1638uvrA0.969
Rv2593cruvA0.968
Rv2593cruvA0.968
Rv2593cruvA0.968
Rv2594cruvC0.965
Rv2592cruvB0.964
Rv2592cruvB0.964
Rv1537dinX0.952
Rv1537dinX0.952
Rv1537dinX0.952
Rv2973crecG0.947
Rv2973crecG0.947
Rv2973crecG0.947
Rv0667rpoB0.939
Rv0667rpoB0.939
Rv0667rpoB0.939
Rv0667rpoB0.939
Rv0667rpoB0.939
Rv0667rpoB0.939
Rv2150cftsZ0.934
Rv2150cftsZ0.934
Rv0006gyrA0.933
Rv0006gyrA0.933
Rv1547dnaE10.929
Rv1547dnaE10.929
Rv1547dnaE10.929
Rv1547dnaE10.929
Rv1420uvrC0.927
Rv1420uvrC0.927
Rv1420uvrC0.927
Rv1420uvrC0.927
Rv0003recF0.926
Rv2736crecX0.92
Rv0001dnaA0.916
Rv0001dnaA0.916
Rv1657argR0.91
Rv1657argR0.91
Rv0054ssb0.902
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
glycerolPubChem0.70792.0938