Rv2973c

Tuberculist information
Gene namerecG
Protein functionProbable ATP-dependent DNA helicase RecG
Functional category(tuberculist)information pathways
Gene location(kb)3327.73
Molecular mass(da)80329
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 737
	  		  	1    VASLSDRLDRVLGATAADALDEQFGMRTVDDLLRHYPRSYVEGAARVGIGDARPEAGEHI   60
			  	61   TIVDVITDTYSFPMKKKPNRKCLRITVGGGRNKVTATFFNADYIMRDLTKHTKVMLSGEV  120
			  	121  GYYKGAMQLTHPAFLILDSPDGKNHGTRSLKSIADASKAISGELVVEEFERRFFPIYPAS  180
			  	181  TKVQSWDIFKCVRQVLDVLDRVDDPLPAELRAKHGLIPEDEALRAIHLAESQSLRERARE  240
			  	241  RLTFDEAVGLQWALVARRHGELSESGPSAAWKSNGLAAELLRRLPFELTAGQREVLDVLS  300
			  	301  DGLAANRPLNRLLQGEVGSGKTIVAVLAMLQMVDAGYQCALLAPTEVLAAQHLRSIRDVL  360
			  	361  GPLAMGGQLGGAENATRVALLTGSMTAGQKKQVRAEIASGQVGIVIGTHALLQEAVDFHN  420
			  	421  LGMVVVDEQHRFGVEQRDQLRAKAPAGITPHLLVMTATPIPRTVALTVYGDLETSTLREL  480
			  	481  PLGRQPIATNVIFVKDKPAWLDRAWRRIIEEAAAGRQAYVVAPRIDESDDTDVQGGVRPS  540
			  	541  ATAEGLFSRLRSAELAELRLALMHGRLSADDKDAAMAAFRAGEVDVLVCTTVIEVGVDVP  600
			  	601  NATVMLVMDADRFGISQLHQLRGRIGRGEHPSVCLLASWVPPDTPAGQRLRAVAGTMDGF  660
			  	661  ALADLDLKERKEGDVLGRNQSGKAITLRLLSLAEHEEYIVAARDFCIEAYKNPTDPALAL  720
			  	721  MAARFTSTDRIEYLDKS

Known structures in the PDB
No Known structures
1 74 147 220 293 366 439 512 585 658 731 Range: 60 to 137  |  Coverage: 10% tRNA_anti-codon Range: 289 to 467  |  Coverage: 24% DEAD Range: 552 to 629  |  Coverage: 10% Helicase_C Range: 3 to 700  |  Coverage: 94% 1 Range: 6 to 736  |  Coverage: 99% 2 Range: 289 to 467  |  Coverage: 24% 1
Number of amino acids : 737
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
tRNA_anti-codonPF0133660-137
DEADPF00270289-467
Helicase_CPF00271552-629
Mtb Structural Proteome models
Model Number1
Model nameRv2973c
Template1GM5    APDBCREDO
Template coverage114_754
Template Identity(%)35.6
Model coverage(%)94.6
Normalized DOPE score0.756

Model Number2
Model nameRv2973c.2
Template2EYQ    APDBCREDO
Template coverage309_1029
Template Identity(%)24.0
Model coverage(%)99.1
Normalized DOPE score0.9

Structure Models from Chopin
Model Number1
Profilec.37.1.23
Click for model details
zscore14.2
Residue begin289
Residue end467
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2973cGene nameConfidence Score
Rv2592cruvB0.985
Rv2592cruvB0.985
Rv2737crecA0.975
Rv2737crecA0.975
Rv1696recN0.966
Rv2594cruvC0.963
Rv2974cRv2974c0.961
Rv2974cRv2974c0.961
Rv1638uvrA0.953
Rv0949uvrD10.951
Rv0949uvrD10.951
Rv2593cruvA0.95
Rv2593cruvA0.95
Rv2593cruvA0.95
Rv2720lexA0.947
Rv2720lexA0.947
Rv1389gmk0.933
Rv0054ssb0.929
Rv3674cnth0.918
Rv3674cnth0.918
Rv3674cnth0.918
Rv0058dnaB0.909
Rv0058dnaB0.909
Rv0058dnaB0.909
Rv0058dnaB0.909
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
No high confidence interactions