Tuberculist information
Gene nameRv2974c
Protein functionConserved hypothetical alanine rich protein
Functional category(tuberculist)conserved hypotheticals
Gene location(kb)3329.95
Molecular mass(da)46685
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 470
	  		  	1    LNGARGNSGVILSQILRGIAEVTATAAAASGAVLRAVDANALGAALWRGVELVVASMGGV   60
			  	61   EVPGTIVSVLRAAAGAVDQCAHEGLAGAVTAAGDAAVIALEKTPEQLDVLADAGAVDAGG  120
			  	121  RGLLVLLDALRSTICGQAPARAVYEPSPRALPTDTATQRPAPQFEVMYLLAVCDAAAADQ  180
			  	181  LRDRLKELGESVAIAAAPPDSYSVHVHTDDAGAAVEAGLAVGRVSRIVISALGSGTSGLP  240
			  	241  AGGWTRGRAVLAVVDGDGAAELFAGEGACVLRPGPDAVTPAADISAHQLVRAVVDTGAAH  300
			  	301  VMVLPNGYVAAEELVAGCTAAIGWGVDVVPVPTGSMVQGLAALAVHDAARQAVDDGYSMA  360
			  	361  RAAGASRHGSVRIATQKALTWAGTCKPGDGLGIAGDEVLIVADDVAAAAIGLVDLLLASG  420
			  	421  GDLVTVLIGAGVTEDVAVVLERHVHDHHPGTELVSYRTGHRGDALLIGVE
			  			

Known structures in the PDB
No Known structures
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Dak2PF027341-132
Dak1_2PF13684161-470
Mtb Structural Proteome models
Model Number1
Model nameRv2974c.1
Template2BTD    APDBCREDO
Template coverage73_210
Template Identity(%)16.2
Model coverage(%)28.7
Normalized DOPE score0.216

Model Number2
Model nameRv2974c
Template1FTS    APDBCREDO
Template coverage202_461
Template Identity(%)11.4
Model coverage(%)48.3
Normalized DOPE score0.946

Structure Models from Chopin
Model Number1
Profiled.157.1.10
Click for model details
zscore4.2
Residue begin161
Residue end469
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2974cGene nameConfidence Score
Rv2975cRv2975c0.988
Rv2973crecG0.961
Rv2973crecG0.961
Rv2973crecG0.961
Rv2417cRv2417c0.925
Potential ligand/drug binding sites
Protein ModelPocket NumberDrug Binding Site PMIN ScorePvalue PMINPMAX ScorePvalue PMAX
Rv2974c.121n49_RIT_D_401PDBCREDO0.7900.0290.7900.000
Rv2974c.121n49_RIT_B_301PDBCREDO0.8040.0230.7390.000
Rv2974c.123spk_TPV_B_100PDBCREDO0.7500.0480.7290.000
Rv2974c.123lzv_017_A_200PDBCREDO0.7410.0530.7000.000
Rv2974c.123ogp_017_B_200PDBCREDO0.6980.0830.6980.000
Rv2974c.123el0_1UN_A_201PDBCREDO0.7380.0540.6980.000
Rv2974c.122r5q_1UN_B_900PDBCREDO0.7000.0810.6800.000
Rv2974c.123ogp_017_A_200PDBCREDO0.7420.0520.6790.000
Rv2974c.122r5q_1UN_D_900PDBCREDO0.6970.0830.6770.000
Rv2974c.123so9_017_A_100PDBCREDO0.7580.0430.6730.000
Rv2974c.121sgu_MK1_B_2632PDBCREDO0.6670.1080.6670.001
Rv2974c.121c6y_MK1_B_524PDBCREDO0.7590.0430.6610.001
Rv2974c.123ekq_ROC_A_100PDBCREDO0.7310.0590.6530.001
Rv2974c.122o4p_TPV_A_300PDBCREDO0.6730.1030.6530.001
Rv2974c.122o4n_TPV_A_300PDBCREDO0.7310.0590.6490.001
Rv2974c.122b7z_MK1_B_200PDBCREDO0.6450.1300.6450.001
Rv2974c.121hsh_MK1_A_401PDBCREDO0.7390.0540.6430.001
Rv2974c.121d4y_TPV_A_501PDBCREDO0.7220.0650.6410.001
Rv2974c.123ufn_ROC_A_401PDBCREDO0.7730.0360.6380.001
Rv2974c.122qhc_AB1_B_9001PDBCREDO0.6510.1240.6330.001
Rv2974c.122qxs_RAL_A_600PDBCREDO0.7060.0760.6320.001
Rv2974c.122qxs_RAL_B_600PDBCREDO0.7060.0760.6310.001
Rv2974c.122bpx_MK1_B_902PDBCREDO0.6670.1090.6300.001
Rv2974c.123gp0_NIL_A_1PDBCREDO0.7630.0410.6300.001
Rv2974c.133lfa_1N1_A_361PDBCREDO0.7840.0310.6280.001
Rv2974c.121hsh_MK1_C_402PDBCREDO0.7200.0660.6270.001
Rv2974c.123oy4_017_B_200PDBCREDO0.6450.1300.6260.001
Rv2974c.121t7j_478_A_200PDBCREDO0.7040.0780.6250.001
Rv2974c.121sh9_RIT_B_301PDBCREDO0.7170.0690.6240.001
Rv2974c.122z54_AB1_A_200PDBCREDO0.6420.1320.6240.001
Rv2974c.124dqe_017_B_101PDBCREDO0.6410.1330.6230.001
Rv2974c.123ebz_017_B_201PDBCREDO0.6410.1340.6220.001
Rv2974c.122qak_1UN_A_1001PDBCREDO0.8340.0140.6220.001
Rv2974c.121ohr_1UN_A_201PDBCREDO0.7140.0700.6220.001
Rv2974c.131gwr_EST_A_600PDBCREDO0.6510.1230.6220.001
Rv2974c.122q64_1UN_B_1001PDBCREDO0.8330.0140.6210.001
Rv2974c.122pyn_1UN_A_1001PDBCREDO0.8290.0150.6180.001
Rv2974c.122q63_1UN_A_1001PDBCREDO0.8280.0160.6170.002
Rv2974c.123nu9_478_A_401PDBCREDO0.6520.1220.6160.002
Rv2974c.122pym_1UN_A_1001PDBCREDO0.8270.0160.6160.002
Rv2974c.123ogq_AB1_A_200PDBCREDO0.7840.0310.6150.002
Rv2974c.133hm1_J3Z_A_2PDBCREDO0.6430.1310.6140.002
Rv2974c.123em6_017_A_200PDBCREDO0.6480.1260.6130.002
Rv2974c.123ggu_017_B_201PDBCREDO0.7610.0420.6120.002
Rv2974c.131ere_EST_A_600PDBCREDO0.6410.1330.6120.002
Rv2974c.131gwr_EST_B_600PDBCREDO0.6410.1330.6120.002
Rv2974c.123el9_DR7_A_100PDBCREDO0.7030.0780.6120.002
Rv2974c.123s56_ROC_A_201PDBCREDO0.7030.0780.6120.002
Rv2974c.131qku_EST_A_600PDBCREDO0.6400.1340.6110.002
Rv2974c.133ug2_IRE_A_1PDBCREDO0.6720.1040.6100.002
Rv2974c.131qku_EST_B_600PDBCREDO0.6370.1380.6080.002
Rv2974c.131qku_EST_C_600PDBCREDO0.6370.1380.6080.002
Rv2974c.131ere_EST_E_600PDBCREDO0.6360.1390.6070.002
Rv2974c.131pcg_EST_B_2PDBCREDO0.6350.1400.6060.002
Rv2974c.131ere_EST_B_600PDBCREDO0.6330.1410.6050.002
Rv2974c.131g50_EST_B_1600PDBCREDO0.6330.1410.6050.002
Rv2974c.123gcs_BAX_A_401PDBCREDO0.6410.1340.6050.002
Rv2974c.121hpv_478_B_200PDBCREDO0.6390.1360.6040.002
Rv2974c.123ttp_017_A_201PDBCREDO0.6390.1360.6030.002
Rv2974c.121sa1_POD_B_700PDBCREDO0.6390.1360.6020.002
Rv2974c.123s53_017_A_201PDBCREDO0.6550.1200.6020.002
Rv2974c.121hxw_RIT_B_301PDBCREDO0.7430.0520.5970.002
Rv2974c.121mui_AB1_B_100PDBCREDO0.6710.1040.5960.002
Rv2974c.124asd_BAX_A_1500PDBCREDO0.6320.1430.5960.002
Rv2974c.122rkg_AB1_B_501PDBCREDO0.6700.1060.5950.002
Rv2974c.131xbb_STI_A_1PDBCREDO0.6550.1200.5950.002
Rv2974c.121sa1_POD_D_701PDBCREDO0.6490.1250.5950.002
Rv2974c.123lzs_017_A_200PDBCREDO0.6290.1460.5940.002
Rv2974c.123nu6_478_B_401PDBCREDO0.6640.1110.5930.002
Rv2974c.123spk_TPV_A_100PDBCREDO0.8100.0210.5930.002
Rv2974c.123oxw_017_D_200PDBCREDO0.6460.1290.5930.002
Rv2974c.123heg_BAX_A_1PDBCREDO0.6480.1270.5930.002
Rv2974c.123n3i_ROC_A_201PDBCREDO0.6450.1300.5920.002
Rv2974c.124dqh_017_B_101PDBCREDO0.6440.1300.5920.002
Rv2974c.123t3c_017_A_201PDBCREDO0.6620.1130.5920.002
Rv2974c.123oxw_017_B_200PDBCREDO0.6420.1320.5900.003
Rv2974c.121xkk_FMM_A_91PDBCREDO0.7310.0590.5880.003
Rv2974c.121hsg_MK1_B_902PDBCREDO0.6750.1010.5870.003
Rv2974c.122idw_017_B_401PDBCREDO0.5860.1960.5860.003
Rv2974c.121rl8_RIT_A_9001PDBCREDO0.8050.0230.5850.003
Rv2974c.122f80_017_B_301PDBCREDO0.7840.0310.5850.003
Rv2974c.121t46_STI_A_3PDBCREDO0.6860.0920.5810.003
Rv2974c.131a52_EST_B_2PDBCREDO0.6950.0840.5810.003
Rv2974c.124dqc_017_A_101PDBCREDO0.6500.1250.5810.003
Rv2974c.123s45_478_B_201PDBCREDO0.6150.1610.5810.003
Rv2974c.121hxb_ROC_A_100PDBCREDO0.7780.0340.5800.003
Rv2974c.122aoj_FRD_C_305PDBCREDO0.5970.1830.5800.003
Rv2974c.122q5k_AB1_A_201PDBCREDO0.6480.1270.5790.003
Rv2974c.131qkt_EST_A_600PDBCREDO0.6920.0870.5780.003
Rv2974c.132j7x_EST_A_1454PDBCREDO0.6920.0870.5780.003
Rv2974c.133ads_IMN_B_3PDBCREDO0.6920.0870.5780.003
Rv2974c.123oez_STI_A_601PDBCREDO0.5780.2060.5780.003
Rv2974c.131r9o_FLP_A_501PDBCREDO0.6050.1730.5770.003
Rv2974c.132ocf_EST_A_596PDBCREDO0.6900.0890.5760.003
Rv2974c.133hm1_J3Z_B_1PDBCREDO0.6890.0900.5750.003
Rv2974c.123em4_DR7_A_100PDBCREDO0.6610.1140.5750.003
Rv2974c.131a52_EST_A_1PDBCREDO0.6880.0900.5740.003
Rv2974c.131ere_EST_F_600PDBCREDO0.6880.0900.5740.003
Rv2974c.121c6z_ROC_B_505PDBCREDO0.7700.0370.5740.003
Rv2974c.122jfa_RAL_B_600PDBCREDO0.6650.1100.5730.003
Rv2974c.131ere_EST_C_600PDBCREDO0.6850.0920.5730.003
Rv2974c.131pcg_EST_A_1PDBCREDO0.6850.0920.5730.003
Rv2974c.121err_RAL_B_600PDBCREDO0.6640.1110.5720.003
Rv2974c.131ere_EST_D_600PDBCREDO0.6840.0930.5720.003
Rv2974c.131g50_EST_C_2600PDBCREDO0.6840.0930.5720.003
Rv2974c.133oll_EST_A_600PDBCREDO0.6840.0930.5720.003
Rv2974c.121err_RAL_A_600PDBCREDO0.6630.1120.5710.004
Rv2974c.133oll_EST_B_600PDBCREDO0.6830.0940.5710.004
Rv2974c.123sm2_478_A_126PDBCREDO0.7470.0500.5710.004
Rv2974c.131sn0_T44_C_601PDBCREDO0.6250.1510.5700.004
Rv2974c.123ekp_478_B_200PDBCREDO0.5680.2190.5680.004
Rv2974c.123el5_1UN_B_201PDBCREDO0.7400.0530.5660.004
Rv2974c.122aoh_FRD_C_305PDBCREDO0.6180.1580.5660.004
Rv2974c.123bvb_017_B_401PDBCREDO0.7950.0270.5640.004
Rv2974c.123ekx_1UN_B_201PDBCREDO0.7190.0670.5640.004
Rv2974c.122jfa_RAL_A_600PDBCREDO0.6750.1010.5640.004
Rv2974c.122pl0_STI_A_200PDBCREDO0.6150.1610.5630.004
Rv2974c.123nu4_478_B_401PDBCREDO0.6640.1110.5630.004
Rv2974c.133ols_EST_B_600PDBCREDO0.7630.0410.5620.004
Rv2974c.131uay_ADN_A_1001PDBCREDO0.5880.1940.5610.004
Rv2974c.121t7i_017_A_200PDBCREDO0.8290.0150.5610.004
Rv2974c.131g50_EST_A_600PDBCREDO0.7600.0430.5600.004
Rv2974c.133ols_EST_A_600PDBCREDO0.7600.0430.5600.004
Rv2974c.132yja_EST_B_1550PDBCREDO0.7590.0430.5590.004
Rv2974c.123pwr_ROC_A_401PDBCREDO0.7870.0300.5580.004
Rv2974c.121sdv_MK1_B_902PDBCREDO0.6590.1160.5580.004
Rv2974c.123oxv_478_C_200PDBCREDO0.6580.1170.5580.004
Rv2974c.121k6c_MK1_B_902PDBCREDO0.8230.0170.5570.004
Rv2974c.133uud_EST_A_600PDBCREDO0.7550.0450.5570.004
Rv2974c.133uud_EST_B_600PDBCREDO0.7550.0450.5570.004
Rv2974c.123cs9_NIL_A_600PDBCREDO0.6050.1730.5560.005
Rv2974c.124dqb_017_B_101PDBCREDO0.6550.1200.5550.005
Rv2974c.123u7s_017_A_202PDBCREDO0.6840.0930.5530.005
Rv2974c.123el4_ROC_A_100PDBCREDO0.8170.0190.5530.005
Rv2974c.122fxd_DR7_A_102PDBCREDO0.6340.1400.5520.005
Rv2974c.122b60_RIT_B_100PDBCREDO0.6650.1100.5490.005
Rv2974c.123oxv_478_B_200PDBCREDO0.5970.1830.5480.005
Rv2974c.122oiq_STI_A_1001PDBCREDO0.5980.1810.5470.005
Rv2974c.123ucb_017_A_201PDBCREDO0.7890.0290.5470.005
Rv2974c.123nuo_478_B_478PDBCREDO0.6620.1130.5460.005
Rv2974c.121jg2_ADN_A_500PDBCREDO0.7940.0270.5430.006
Rv2974c.122r5p_MK1_D_902PDBCREDO0.6750.1020.5420.006
Rv2974c.122nnk_ROC_A_401PDBCREDO0.7830.0320.5420.006
Rv2974c.123ndt_ROC_D_100PDBCREDO0.7830.0320.5420.006
Rv2974c.123cs9_NIL_C_600PDBCREDO0.6390.1360.5410.006
Rv2974c.122hyy_STI_A_600PDBCREDO0.5410.2560.5410.006
Rv2974c.122y6o_1N1_A_1892PDBCREDO0.6690.1060.5410.006
Rv2974c.123pyy_STI_A_3PDBCREDO0.5410.2560.5410.006
Rv2974c.123cs9_NIL_B_600PDBCREDO0.6050.1730.5410.006
Rv2974c.123cs9_NIL_D_600PDBCREDO0.6380.1360.5410.006
Rv2974c.122nnp_ROC_A_401PDBCREDO0.7990.0250.5400.006
Rv2974c.123mss_STI_C_1PDBCREDO0.5400.2580.5400.006
Rv2974c.132zva_1N1_A_513PDBCREDO0.7620.0410.5400.006
Rv2974c.123mss_STI_B_1PDBCREDO0.5400.2590.5400.006
Rv2974c.121opj_STI_A_3PDBCREDO0.5870.1950.5390.006
Rv2974c.123ms9_STI_A_1PDBCREDO0.5390.2590.5390.006
Rv2974c.122r5p_MK1_B_902PDBCREDO0.6700.1050.5390.006
Rv2974c.132uxp_CLM_B_1211PDBCREDO0.5650.2240.5390.006
Rv2974c.121iep_STI_A_201PDBCREDO0.5390.2600.5390.006
Rv2974c.123k5v_STI_B_2PDBCREDO0.5380.2610.5380.006
Rv2974c.123mss_STI_A_1PDBCREDO0.5380.2610.5380.006
Rv2974c.123eky_DR7_A_100PDBCREDO0.6690.1070.5380.006
Rv2974c.123ms9_STI_B_1PDBCREDO0.5370.2620.5370.006
Rv2974c.121iep_STI_B_202PDBCREDO0.5370.2620.5370.006
Rv2974c.122hyy_STI_D_600PDBCREDO0.5370.2620.5370.006
Rv2974c.123mss_STI_D_1PDBCREDO0.5370.2620.5370.006
Rv2974c.123pyy_STI_B_4PDBCREDO0.5370.2620.5370.006
Rv2974c.123rgf_BAX_A_465PDBCREDO0.5520.2410.5370.006
Rv2974c.123gvu_STI_A_1001PDBCREDO0.5360.2640.5360.006
Rv2974c.122fxe_DR7_A_102PDBCREDO0.6660.1090.5360.006
Rv2974c.121sdu_MK1_B_902PDBCREDO0.6830.0940.5360.006
Rv2974c.122hyy_STI_B_600PDBCREDO0.5840.1980.5350.006
Rv2974c.122hyy_STI_C_600PDBCREDO0.5350.2660.5350.006
Rv2974c.123em4_DR7_V_100PDBCREDO0.6650.1110.5340.006
Rv2974c.121opj_STI_B_4PDBCREDO0.5810.2020.5340.006
Rv2974c.123v5w_8PR_A_701PDBCREDO0.6820.0960.5340.006
Rv2974c.123el1_DR7_A_100PDBCREDO0.6770.1000.5310.007
Rv2974c.123ekw_DR7_B_100PDBCREDO0.6760.1010.5300.007
Rv2974c.123oez_STI_B_601PDBCREDO0.6330.1410.5290.007
Rv2974c.123k5v_STI_A_2PDBCREDO0.5580.2330.5270.007
Rv2974c.121uwj_BAX_A_1723PDBCREDO0.5420.2560.5260.007
Rv2974c.123e22_LOC_D_700PDBCREDO0.6280.1470.5240.008
Rv2974c.122rkf_AB1_A_501PDBCREDO0.6520.1230.5240.008
Rv2974c.123bbt_FMM_D_91PDBCREDO0.7390.0540.5240.008
Rv2974c.132uxp_CLM_A_1211PDBCREDO0.5480.2470.5230.008
Rv2974c.123hec_STI_A_1PDBCREDO0.6250.1500.5220.008
Rv2974c.123e22_LOC_B_700PDBCREDO0.6250.1510.5210.008
Rv2974c.123em3_478_B_200PDBCREDO0.6640.1110.5210.008
Rv2974c.123ekv_478_A_200PDBCREDO0.6630.1120.5200.008
Rv2974c.123k4v_ROC_D_201PDBCREDO0.7870.0300.5200.008
Rv2974c.131cqp_803_A_311PDBCREDO0.5440.2530.5190.008
Rv2974c.123d1y_ROC_A_201PDBCREDO0.7130.0710.5190.008
Rv2974c.124dqf_017_B_101PDBCREDO0.6610.1140.5180.008
Rv2974c.123lzu_017_A_200PDBCREDO0.5950.1840.5180.008
Rv2974c.123h52_486_A_3PDBCREDO0.5830.2000.5180.008
Rv2974c.131sn5_T3_C_601PDBCREDO0.6460.1290.5170.008
Rv2974c.131mx1_THA_B_2PDBCREDO0.6720.1040.5160.009
Rv2974c.131s9p_DES_C_500PDBCREDO0.7260.0620.5150.009
Rv2974c.122aoi_FRD_C_305PDBCREDO0.6900.0880.5150.009
Rv2974c.133vkx_T3_A_301PDBCREDO0.5380.2610.5130.009
Rv2974c.123ekp_478_C_200PDBCREDO0.5880.1930.5120.009
Rv2974c.122aqu_DR7_B_300PDBCREDO0.6700.1060.5120.009
Rv2974c.123tkg_ROC_C_901PDBCREDO0.7930.0270.5120.009
Rv2974c.121uwj_BAX_B_1723PDBCREDO0.5430.2540.5120.009
Rv2974c.122avo_MK1_B_902PDBCREDO0.6870.0910.5120.009
Rv2974c.133adx_IMN_B_3PDBCREDO0.6910.0880.5090.009
Rv2974c.131s9p_DES_B_459PDBCREDO0.7190.0670.5090.009
Rv2974c.131ya4_CTX_B_2PDBCREDO0.7190.0670.5090.009
Rv2974c.123oxx_DR7_A_100PDBCREDO0.6650.1100.5090.010
Rv2974c.121uwh_BAX_A_1723PDBCREDO0.5720.2130.5080.010
Rv2974c.121uwh_BAX_B_1723PDBCREDO0.5720.2140.5080.010
Rv2974c.122w8y_486_A_1000PDBCREDO0.5380.2610.5070.010
Rv2974c.131mx1_THA_A_1PDBCREDO0.6330.1410.5070.010
Rv2974c.131sn5_T3_D_602PDBCREDO0.5560.2360.5070.010
Rv2974c.131ya4_CTX_C_3PDBCREDO0.7150.0700.5070.010
Rv2974c.122avs_MK1_B_902PDBCREDO0.6790.0980.5060.010
Rv2974c.123u7s_017_A_201PDBCREDO0.6900.0880.5060.010
Rv2974c.122aof_FRD_C_305PDBCREDO0.7640.0400.5050.010
Rv2974c.133bbt_FMM_B_91PDBCREDO0.7700.0380.5040.010
Rv2974c.131tbf_VIA_A_501PDBCREDO0.5280.2750.5040.010
Rv2974c.123ut5_LOC_B_502PDBCREDO0.5660.2210.5030.010
Rv2974c.123h52_486_B_1PDBCREDO0.5470.2480.5010.011
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
No high confidence interactions