Rv2150c

Tuberculist information
Gene nameftsZ
Protein functionCell division protein FtsZ
Functional category(tuberculist)cell wall and cell processes
Gene location(kb)2408.39
Molecular mass(da)38755.9
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 379
	  		  	1    MTPPHNYLAVIKVVGIGGGGVNAVNRMIEQGLKGVEFIAINTDAQALLMSDADVKLDVGR   60
			  	61   DSTRGLGAGADPEVGRKAAEDAKDEIEELLRGADMVFVTAGEGGGTGTGGAPVVASIARK  120
			  	121  LGALTVGVVTRPFSFEGKRRSNQAENGIAALRESCDTLIVIPNDRLLQMGDAAVSLMDAF  180
			  	181  RSADEVLLNGVQGITDLITTPGLINVDFADVKGIMSGAGTALMGIGSARGEGRSLKAAEI  240
			  	241  AINSPLLEASMEGAQGVLMSIAGGSDLGLFEINEAASLVQDAAHPDANIIFGTVIDDSLG  300
			  	301  DEVRVTVIAAGFDVSGPGRKPVMGETGGAHRIESAKAGKLTSTLFEPVDAVSVPLHTNGA  360
			  	361  TLSIGGDDDDVDVPPFMRR

Known structures in the PDB
PDB ID1RLU
Total residue count764
Number of chains2
MethodX-RAY
Resolution2.08
PDB ID1RQ2
Total residue count764
Number of chains2
MethodX-RAY
Resolution1.86
PDB ID1RQ7
Total residue count764
Number of chains2
MethodX-RAY
Resolution2.6
PDB ID2Q1X
Total residue count758
Number of chains2
MethodX-RAY
Resolution2.35
PDB ID2Q1Y
Total residue count758
Number of chains2
MethodX-RAY
Resolution2.3
PDB ID4KWE
Total residue count1146
Number of chains3
MethodX-RAY
Resolution2.91
1 38 75 112 149 186 223 260 297 334 371 Range: 10 to 182  |  Coverage: 45% Tubulin Range: 219 to 313  |  Coverage: 24% FtsZ_C Range: 8 to 312  |  Coverage: 80% 1 Range: 8 to 312  |  Coverage: 80% 2 Range: 1 to 328  |  Coverage: 86% 1 Range: 200 to 328  |  Coverage: 33% 2 Range: 10 to 182  |  Coverage: 45% 3
Number of amino acids : 379
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
TubulinPF0009110-182
FtsZ_CPF12327219-313
Mtb Structural Proteome models
Model Number1
Model nameRv2150c_1rq2_A
Template1RQ2    APDBCREDO
Template coverage8_312
Template Identity(%)100.0
Model coverage(%)80.2
Normalized DOPE score-2.237

Model Number2
Model nameRv2150c
Template1RQ2    APDBCREDO
Template coverage8_312
Template Identity(%)99.7
Model coverage(%)80.2
Normalized DOPE score-1.851

Structure Models from Chopin
Model Number1
Profilec.32.1.1, d.79.2.1 - 3.30.1330.20, 3.40.50.1440
Click for model details
zscore66.35
Residue begin1
Residue end328
Model Number2
Profiled.79.2.1
Click for model details
zscore29.17
Residue begin200
Residue end328
Model Number3
Profilec.32.1.1
Click for model details
zscore15.78
Residue begin10
Residue end182
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2150cGene nameConfidence Score
Rv2154cftsW0.999
Rv2158cmurE0.996
Rv2155cmurD0.996
Rv2457cclpX0.996
Rv2158cmurE0.996
Rv2457cclpX0.996
Rv2158cmurE0.996
Rv2457cclpX0.996
Rv2153cmurG0.996
Rv2153cmurG0.996
Rv2155cmurD0.996
Rv0017crodA0.994
Rv2151cftsQ0.994
Rv2151cftsQ0.994
Rv2147cRv2147c0.993
Rv2748cftsK0.991
Rv2748cftsK0.991
Rv2748cftsK0.991
Rv2165cRv2165c0.989
Rv2157cmurF0.982
Rv2157cmurF0.982
Rv2157cmurF0.982
Rv1315murA0.982
Rv0482murB0.981
Rv0482murB0.981
Rv2156cmurX0.979
Rv2156cmurX0.979
Rv2152cmurC0.978
Rv2152cmurC0.978
Rv2152cmurC0.978
Rv2149cyfiH0.975
Rv2166cRv2166c0.973
Rv0667rpoB0.972
Rv0667rpoB0.972
Rv0667rpoB0.972
Rv0667rpoB0.972
Rv0667rpoB0.972
Rv0667rpoB0.972
Rv2981cddlA0.971
Rv2981cddlA0.971
Rv2148cRv2148c0.968
Rv0015cpknA0.968
Rv3610cftsH0.966
Rv3610cftsH0.966
Rv3610cftsH0.966
Rv0001dnaA0.965
Rv0001dnaA0.965
Rv2163cpbpB0.964
Rv2163cpbpB0.964
Rv0640rplK0.957
Rv0640rplK0.957
Rv3443crplM0.957
Rv0685tuf0.947
Rv0685tuf0.947
Rv0685tuf0.947
Rv2921cftsY0.946
Rv2921cftsY0.946
Rv0005gyrB0.941
Rv0005gyrB0.941
Rv0005gyrB0.941
Rv0005gyrB0.941
Rv2145cwag310.939
Rv1696recN0.939
Rv2718cnrdR0.938
Rv2882cfrr0.936
Rv0350dnaK0.935
Rv2720lexA0.934
Rv2720lexA0.934
Rv0016cpbpA0.933
Rv0422cthiD0.93
Rv2555calaS0.919
Rv2555calaS0.919
Rv2555calaS0.919
Rv2594cruvC0.919
Rv1536ileS0.918
Rv1536ileS0.918
Rv2737crecA0.916
Rv2737crecA0.916
Rv0684fusA10.915
Rv0684fusA10.915
Rv0684fusA10.915
Rv0684fusA10.915
Rv0684fusA10.915
Rv3628ppa0.912
Rv3457crpoA0.909
Rv3457crpoA0.909
Rv3457crpoA0.909
Rv1437pgk0.906
Rv3646ctopA0.905
Rv3646ctopA0.905
Rv3646ctopA0.905
Rv0041leuS0.904
Rv0041leuS0.904
Rv0041leuS0.904
Rv2462ctig0.903
Rv2462ctig0.903
Rv2462ctig0.903
Rv1617pykA0.902
Rv1617pykA0.902
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
  View results in TIBLE page
NameAffinityAssay descriptionDOI
CHEMBL106808IC50 = 38.1 uMInhibition of Mycobacterium tuberculosis FtsZ polymerization expressed in Escherichia coli by light scattering assayhttp://www.ncbi.nlm.nih.gov/pubmed/22024272
CHEMBL110168IC50 = 34.2 uMInhibition of Mycobacterium tuberculosis FtsZ polymerization expressed in Escherichia coli by light scattering assayhttp://www.ncbi.nlm.nih.gov/pubmed/22024272
CHEMBL1651196Dose-dependent effectInhibition of Mycobacterium tuberculosis FtsZ polymerizationhttp://www.ncbi.nlm.nih.gov/pubmed/21126020
CHEMBL1651196IC50 = 6.21 uMInhibition of Mycobacterium tuberculosis FtsZ polymerizationhttp://www.ncbi.nlm.nih.gov/pubmed/21126020
CHEMBL1651196Inhibition = 80 %Inhibition of Mycobacterium tuberculosis FtsZ polymerization at 10 uMhttp://www.ncbi.nlm.nih.gov/pubmed/21126020
CHEMBL1651199Inhibition = 45 %Inhibition of Mycobacterium tuberculosis FtsZ polymerization at 10 uMhttp://www.ncbi.nlm.nih.gov/pubmed/21126020
CHEMBL1651199ActiveInduction of Mycobacterium tuberculosis FtsZ GTPase activityhttp://www.ncbi.nlm.nih.gov/pubmed/21126020
CHEMBL1651202ActiveInhibition of Mycobacterium tuberculosis FtsZ polymerization at 80 uM by transmission electron microscopyhttp://www.ncbi.nlm.nih.gov/pubmed/21126020
CHEMBL1651202IC50 = 7.69 uMInhibition of Mycobacterium tuberculosis FtsZ polymerizationhttp://www.ncbi.nlm.nih.gov/pubmed/21126020
CHEMBL1651202ActiveInduction of Mycobacterium tuberculosis FtsZ GTPase activityhttp://www.ncbi.nlm.nih.gov/pubmed/21126020
CHEMBL1651202ActiveInhibition of Mycobacterium tuberculosis FtsZ polymerization at 200 uM by transmission electron microscopyhttp://www.ncbi.nlm.nih.gov/pubmed/21126020
CHEMBL1651202ActiveInhibition of Mycobacterium tuberculosis FtsZ polymerization at 40 uM by transmission electron microscopyhttp://www.ncbi.nlm.nih.gov/pubmed/21126020
CHEMBL1926714IC50 > 100 uMInhibition of Mycobacterium tuberculosis FtsZ polymerization expressed in Escherichia coli by light scattering assayhttp://www.ncbi.nlm.nih.gov/pubmed/22024272
CHEMBL1926715IC50 > 100 uMInhibition of Mycobacterium tuberculosis FtsZ polymerization expressed in Escherichia coli by light scattering assayhttp://www.ncbi.nlm.nih.gov/pubmed/22024272
CHEMBL1926716Inhibition = 64 %Inhibition of Mycobacterium tuberculosis FtsZ polymerization expressed in Escherichia coli at 100 uM by light scattering assayhttp://www.ncbi.nlm.nih.gov/pubmed/22024272
CHEMBL1926717IC50 = 16.4 uMInhibition of Mycobacterium tuberculosis FtsZ polymerization expressed in Escherichia coli by light scattering assayhttp://www.ncbi.nlm.nih.gov/pubmed/22024272
CHEMBL1926718Inhibition = 59 %Inhibition of Mycobacterium tuberculosis FtsZ polymerization expressed in Escherichia coli at 100 uM by light scattering assayhttp://www.ncbi.nlm.nih.gov/pubmed/22024272
CHEMBL1926719IC50 = 21 uMInhibition of Mycobacterium tuberculosis FtsZ polymerization expressed in Escherichia coli by light scattering assayhttp://www.ncbi.nlm.nih.gov/pubmed/22024272
CHEMBL1926720IC50 = 34.8 uMInhibition of Mycobacterium tuberculosis FtsZ polymerization expressed in Escherichia coli by light scattering assayhttp://www.ncbi.nlm.nih.gov/pubmed/22024272
CHEMBL1926721IC50 = 54.6 uMInhibition of Mycobacterium tuberculosis FtsZ polymerization expressed in Escherichia coli by light scattering assayhttp://www.ncbi.nlm.nih.gov/pubmed/22024272
CHEMBL1926722IC50 = 27.3 uMInhibition of Mycobacterium tuberculosis FtsZ polymerization expressed in Escherichia coli by light scattering assayhttp://www.ncbi.nlm.nih.gov/pubmed/22024272
CHEMBL1926723IC50 = 34.1 uMInhibition of Mycobacterium tuberculosis FtsZ polymerization expressed in Escherichia coli by light scattering assayhttp://www.ncbi.nlm.nih.gov/pubmed/22024272
CHEMBL1926724IC50 = 18.6 uMInhibition of Mycobacterium tuberculosis FtsZ polymerization expressed in Escherichia coli by light scattering assayhttp://www.ncbi.nlm.nih.gov/pubmed/22024272
CHEMBL1926725IC50 = 29.5 uMInhibition of Mycobacterium tuberculosis FtsZ polymerization expressed in Escherichia coli by light scattering assayhttp://www.ncbi.nlm.nih.gov/pubmed/22024272
CHEMBL1926726IC50 = 46 uMInhibition of Mycobacterium tuberculosis FtsZ polymerization expressed in Escherichia coli by light scattering assayhttp://www.ncbi.nlm.nih.gov/pubmed/22024272
CHEMBL1926727IC50 = 46.2 uMInhibition of Mycobacterium tuberculosis FtsZ polymerization expressed in Escherichia coli by light scattering assayhttp://www.ncbi.nlm.nih.gov/pubmed/22024272
CHEMBL1929425IC50 = 26.8 uMInhibition of Mycobacterium tuberculosis FtsZ polymerization expressed in Escherichia coli by light scattering assayhttp://www.ncbi.nlm.nih.gov/pubmed/22024272
CHEMBL1929426IC50 = 34.3 uMInhibition of Mycobacterium tuberculosis FtsZ polymerization expressed in Escherichia coli by light scattering assayhttp://www.ncbi.nlm.nih.gov/pubmed/22024272
CHEMBL1929427IC50 = 45.7 uMInhibition of Mycobacterium tuberculosis FtsZ polymerization expressed in Escherichia coli by light scattering assayhttp://www.ncbi.nlm.nih.gov/pubmed/22024272
CHEMBL199932ActiveFtsZ inactivation in MTB cells at MIChttp://www.ncbi.nlm.nih.gov/pubmed/16420032
CHEMBL438250ActiveFtsZ inactivation in MTB cells at MIChttp://www.ncbi.nlm.nih.gov/pubmed/16420032
CHEMBL457349IC50 = 52 uMInhibition of Mycobacterium tuberculosis FtsZ polymerization expressed in Escherichia coli by light scattering assayhttp://www.ncbi.nlm.nih.gov/pubmed/22024272
CHEMBL457349ID50 = 52 uMInhibition of Mycobacterium tuberculosis FtsZhttp://www.ncbi.nlm.nih.gov/pubmed/15917508
CDD-167NoneNoneNone
CDD-1767NoneNoneNone
CDD-1767NoneNoneNone
CDD-53207NoneNoneNone
Off-target activity - ligand based from TIBLE
  View results in TIBLE page
Predicted off-targetMethodSummaryFull results
Glutathione S-transferase A1 1GUHPharmMapper3 hydroph + 6 HB + 2 pos/neg + 0 aromLink
Mitogen-activated protein kinase 14 3E92PharmMapper6 hydroph + 4 HB + 0 pos/neg + 0 aromLink
Angiotensin-converting enzyme 1UZFPharmMapper2 hydroph + 3 HB + 2 pos/neg + 0 aromLink
Mitogen-activated protein kinase 14 2ZB0PharmMapper5 hydroph + 3 HB + 0 pos/neg + 0 aromLink
Beta-secretase 1 1YM2PharmMapper5 hydroph + 8 HB + 0 pos/neg + 0 aromLink
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
GTP gamma SPubChem0.997539.246
guanosine diphosphatePubChem0.996443.201
citratePubChem0.995192.124
guanosine 5'-(gamma-thiotriphosphate)PubChem0.969539.246
magnesiumPubChem0.95924.305
PC190723PubChem0.919355.747
viriditoxinPubChem0.906662.594
glycerolPubChem0.992.0938
cinnamaldehydePubChem0.859132.159
acetamidePubChem0.84159.0672
curcuminPubChem0.833368.38
SRI 7614PubChem0.804326.353
DB01864PubChem0.8539.246
DB04315PubChem0.8443.201
1-anilinonaphthalene-8-sulfonic acidPubChem0.788315.344
potassiumPubChem0.78339.0983
anhydrotetracyclinePubChem0.777426.419
gfpPubChem0.777262.127
IPTGPubChem0.752238.301
sulfatePubChem0.7596.0626
G2PPubChem0.75521.208
hydron sulfatePubChem0.75196.157
DB03532PubChem0.75521.208
Na(+)PubChem0.73922.9898
penicillinPubChem0.72334.39
hydride acetatePubChem0.70461.0599
potassium hydridePubChem0.70440.1062
tetracyclinePubChem0.704444.435
01GPubChem0.704608.285
acetatePubChem0.70459.044
tetraethylene glycolPubChem0.704194.226