Rv2156c

Tuberculist information
Gene namemurX
Protein functionProbable phospho-N-acetylmuramoyl-pentappeptidetransferase MurX
Functional category(tuberculist)cell wall and cell processes
Gene location(kb)2416.4
Molecular mass(da)37713.4
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 359
	  		  	1    MRQILIAVAVAVTVSILLTPVLIRLFTKQGFGHQIREDGPPSHHTKRGTPSMGGVAILAG   60
			  	61   IWAGYLGAHLAGLAFDGEGIGASGLLVLGLATALGGVGFIDDLIKIRRSRNLGLNKTAKT  120
			  	121  VGQITSAVLFGVLVLQFRNAAGLTPGSADLSYVREIATVTLAPVLFVLFCVVIVSAWSNA  180
			  	181  VNFTDGLDGLAAGTMAMVTAAYVLITFWQYRNACVTAPGLGCYNVRDPLDLALIAAATAG  240
			  	241  ACIGFLWWNAAPAKIFMGDTGSLALGGVIAGLSVTSRTEILAVVLGALFVAEITSVVLQI  300
			  	301  LTFRTTGRRMFRMAPFHHHFELVGWAETTVIIRFWLLTAITCGLGVALFYGEWLAAVGA

Known structures in the PDB
No Known structures
1 36 71 106 141 176 211 246 281 316 351 Range: 46 to 58  |  Coverage: 3% MraY_sig1 Range: 84 to 277  |  Coverage: 53% Glycos_transf_4 Range: 54 to 253  |  Coverage: 55% 1
Number of amino acids : 359
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
MraY_sig1PF1055546-58
Glycos_transf_4PF0095384-277
Mtb Structural Proteome models
Model Number1
Model nameRv2156c
Template1WPG    APDBCREDO
Template coverage768_994
Template Identity(%)12.5
Model coverage(%)55.4
Normalized DOPE score1.162

Structure Models from Chopin
CHOPIN models not available for this query
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2156cGene nameConfidence Score
Rv2158cmurE0.999
Rv2158cmurE0.999
Rv2155cmurD0.999
Rv2152cmurC0.999
Rv2158cmurE0.999
Rv2155cmurD0.999
Rv2152cmurC0.999
Rv2157cmurF0.999
Rv2152cmurC0.999
Rv2157cmurF0.999
Rv2153cmurG0.999
Rv2157cmurF0.999
Rv2153cmurG0.999
Rv2154cftsW0.995
Rv2150cftsZ0.979
Rv2150cftsZ0.979
Rv0017crodA0.972
Rv2163cpbpB0.97
Rv2163cpbpB0.97
Rv2981cddlA0.96
Rv2981cddlA0.96
Rv0482murB0.958
Rv0482murB0.958
Rv2151cftsQ0.935
Rv2151cftsQ0.935
Rv2165cRv2165c0.93
Rv2166cRv2166c0.925
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
  View results in TIBLE page
NameAffinityAssay descriptionDOI
CHEMBL1923646IC50 = 0.05 ug ml-1Inhibition of Mycobacterium tuberculosis MraY translocasehttp://www.ncbi.nlm.nih.gov/pubmed/22007704
Off-target activity - ligand based from TIBLE
  View results in TIBLE page
Predicted off-targetMethodSummaryFull results
None Noneno_predLink
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
lipid IPubChem0.9741673.04
undecaprenyl-pyrophosphoryl-MurNAc-pentapeptidePubChem0.9741717.05
undecaprenyl phosphatePubChem0.973847.282
UDP-MurNAc-pentapeptidePubChem0.9661149.94
lipid intermediate IIPubChem0.9651920.24
UDP-GlcNAcPubChem0.932607.354
polyuridylic acidPubChem0.929324.181
phosphatePubChem0.92196.9872
adenosine diphosphatePubChem0.9427.201
C04877PubChem0.91051.79
dialaninePubChem0.9160.171
C04882PubChem0.91193.95
protiumPubChem0.92.01576
C04851PubChem0.91673.04
deuteriumPubChem0.92.01588
C05898PubChem0.91920.24
uridine diphosphatePubChem0.9404.161
adenosine triphosphatePubChem0.9507.181
H(+)PubChem0.92.01588
C04702PubChem0.91149.94
D-Ala-D-AlaPubChem0.9160.171
C05897PubChem0.91717.05
UDP-MurNAcPubChem0.776679.416
mureidomycin APubChem0.747840.899