Rv0482

Tuberculist information
Gene namemurB
Protein functionProbable UDP-N-acetylenolpyruvoylglucosamine reductase MurB (UDP-N-acetylmuramate dehydrogenase)
Functional category(tuberculist)cell wall and cell processes
Gene location(kb)570.539
Molecular mass(da)38521
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 369
	  		  	1    MKRSGVGSLFAGAHIAEAVPLAPLTTLRVGPIARRVITCTSAEQVVAALRHLDSAAKTGA   60
			  	61   DRPLVFAGGSNLVIAENLTDLTVVRLANSGITIDGNLVRAEAGAVFDDVVVRAIEQGLGG  120
			  	121  LECLSGIPGSAGATPVQNVGAYGAEVSDTITRVRLLDRCTGEVRWVSARDLRFGYRTSVL  180
			  	181  KHADGLAVPTVVLEVEFALDPSGRSAPLRYGELIAALNATSGERADPQAVREAVLALRAR  240
			  	241  KGMVLDPTDHDTWSVGSFFTNPVVTQDVYERLAGDAATRKDGPVPHYPAPDGVKLAAGWL  300
			  	301  VERAGFGKGYPDAGAAPCRLSTKHALALTNRGGATAEDVVTLARAVRDGVHDVFGITLKP  360
			  	361  EPVLIGCML

Known structures in the PDB
No Known structures
1 37 73 109 145 181 217 253 289 325 361 Range: 33 to 167  |  Coverage: 36% FAD_binding_4 Range: 227 to 366  |  Coverage: 37% MurB_C Range: 20 to 366  |  Coverage: 93% 1 Range: 11 to 369  |  Coverage: 97% 1 Range: 1 to 220  |  Coverage: 59% 2 Range: 246 to 366  |  Coverage: 32% 3
Number of amino acids : 369
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
FAD_binding_4PF0156533-167
MurB_CPF02873227-366
Mtb Structural Proteome models
Model Number1
Model nameRv0482
Template2MBR    APDBCREDO
Template coverage4_330
Template Identity(%)33.9
Model coverage(%)93.8
Normalized DOPE score-0.299

Structure Models from Chopin
Model Number1
Profile3.30.43.10, 3.30.465.10, 3.90.78.10
Click for model details
zscore50.25
Residue begin11
Residue end369
Model Number2
Profiled.145.1.2
Click for model details
zscore31.4
Residue begin1
Residue end220
Model Number3
Profile3.90.78.10
Click for model details
zscore25.3
Residue begin246
Residue end366
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0482Gene nameConfidence Score
Rv2152cmurC0.999
Rv2152cmurC0.999
Rv2152cmurC0.999
Rv1315murA0.999
Rv2155cmurD0.996
Rv2155cmurD0.996
Rv2158cmurE0.995
Rv2158cmurE0.995
Rv2158cmurE0.995
Rv2153cmurG0.995
Rv2153cmurG0.995
Rv2981cddlA0.992
Rv2981cddlA0.992
Rv2157cmurF0.987
Rv2157cmurF0.987
Rv2157cmurF0.987
Rv2150cftsZ0.981
Rv2150cftsZ0.981
Rv2154cftsW0.962
Rv2165cRv2165c0.961
Rv2156cmurX0.958
Rv2156cmurX0.958
Rv1338murI0.953
Rv0017crodA0.952
Rv2166cRv2166c0.949
Rv2163cpbpB0.923
Rv2163cpbpB0.923
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
  View results in TIBLE page
NameAffinityAssay descriptionDOI
CDD-1770NoneNoneNone
Off-target activity - ligand based from TIBLE
  View results in TIBLE page
Predicted off-targetMethodSummaryFull results
Cellular retinoic acid-binding protein 2 1CBSPharmMapper7 hydroph + 2 HB + 1 pos/neg + 0 aromLink
Sulfotransferase family cytosolic 2B member 1 1Q1ZPharmMapper0 hydroph + 8 HB + 2 pos/neg + 0 aromLink
Cellular retinoic acid-binding protein 2 3CBSPharmMapper6 hydroph + 2 HB + 1 pos/neg + 0 aromLink
Aldose reductase 2DUXPharmMapper4 hydroph + 5 HB + 1 pos/neg + 2 aromLink
Insulin receptor 2AUHPharmMapper3 hydroph + 5 HB + 3 pos/neg + 0 aromLink
growth-related oncogene; chemokine CXCL1/GRO-alpha [-] SEAE_value = 2.66e-19 & MaxTC = 0.36Link
Sodium channel protein type III alpha subunit SEAE_value = 1.73e-11 & MaxTC = 0.34Link
Sodium channel protein type I alpha subunit SEAE_value = 1.73e-11 & MaxTC = 0.34Link
5 HT1F Agonist SEAE_value = 2.53e-11 & MaxTC = 0.37Link
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
UDP-N-acetylglucosamine enolpyruvatePubChem0.983677.4
phosphatePubChem0.96396.9872
UDP-MurNAcPubChem0.951679.416
NADPPubChem0.931744.413
NADP(H)PubChem0.919745.421
UDP-GlcNAcPubChem0.918607.354
phosphoenolpyruvatePubChem0.912168.042
H(+)PubChem0.9082.01588
deuteriumPubChem0.9072.01588
adenosine diphosphatePubChem0.9427.201
L-alaninePubChem0.989.0932
protiumPubChem0.92.01576
adenosine triphosphatePubChem0.9507.181
UDP-N-acetylmuramoyl-L-alaninePubChem0.9750.494
flavin adenine dinucleotidePubChem0.839785.55