SInCRe - Rv1338

Tuberculist information

Gene name	murI
Protein function	Probable glutamate racemase MurI
Functional category(tuberculist)	cell wall and cell processes
Gene location(kb)	1505.07
Molecular mass(da)	28642.8
External sites	TB Database TubercuList WebTB

Protein sequence

Number of amino acids : 271

	  		  	1    MNSPLAPVGVFDSGVGGLTVARAIIDQLPDEDIVYVGDTGNGPYGPLTIPEIRAHALAIG   60
			  	61   DDLVGRGVKALVIACNSASSACLRDARERYQVPVVEVILPAVRRAVAATRNGRIGVIGTR  120
			  	121  ATITSHAYQDAFAAARDTEITAVACPRFVDFVERGVTSGRQVLGLAQGYLEPLQRAEVDT  180
			  	181  LVLGCTHYPLLSGLIQLAMGENVTLVSSAEETAKEVVRVLTEIDLLRPHDAPPATRIFEA  240
			  	241  TGDPEAFTKLAARFLGPVLGGVQPVHPSRIH

Known structures in the PDB

No Known structures

Number of amino acids : 271

Domains assigned based on sequence.

Mtb Structural proteome models

CHOPIN models

Profile-based domain assignment

Structural/Functional domain family	Pfam acc.no./SCOP ID	Domain Region
Asp_Glu_race	PF01177	8-217

Mtb Structural Proteome models

Model Number	1
Model name	Rv1338
Template	1ZUW APDB CREDO
Template coverage	4_265
Template Identity(%)	42.4
Model coverage(%)	95.6
Normalized DOPE score	-1.409

Structure Models from Chopin

Model Number	1
Profile	3.40.50.1860 Click for model details
zscore	22.89
Residue begin	3
Residue end	159

Model Number	2
Profile	c.78.2.1 - 3.40.50.1860 Click for model details
zscore	13.8
Residue begin	98
Residue end	204

Model Number	3
Profile	c.78.2.1 Click for model details
zscore	12.21
Residue begin	1
Residue end	113

Binding pockets

STRING

Cytoscape Web will replace the contents of this div with protein-protein interaction network.

Protein interacting with Rv1338	Gene name	Confidence Score
Rv2155c	murD	0.985
Rv2155c	murD	0.985
Rv1340	rphA	0.984
Rv1340	rphA	0.984
Rv1341	Rv1341	0.978
Rv0482	murB	0.953
Rv0482	murB	0.953
Rv2981c	ddlA	0.941
Rv2981c	ddlA	0.941
Rv1336	cysM	0.921

Potential ligand/drug binding sites

No binding sites identified

Similarity to known drug target from sensitive sequence analysis

No drug targets

List of small molecules tested from TIBLE

Data not available

Off-target activity - ligand based from TIBLE

Data not available

Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.

Data not available

STITCH interactions

Chemical Name	Confidence score	Molecular Weight
D-glutamatePubChem	0.998	147.129
glutamatePubChem	0.997	147.129
UDP-N-acetylmuramoyl-L-alaninePubChem	0.977	750.494
H(+)PubChem	0.9	2.01588
phosphatePubChem	0.9	96.9872
protiumPubChem	0.9	2.01576
UAGPubChem	0.9	879.608
adenosine diphosphatePubChem	0.9	427.201
deuteriumPubChem	0.9	2.01588
adenosine triphosphatePubChem	0.9	507.181
D-glutaminePubChem	0.843	146.145
calciumPubChem	0.787	40.078
SeMetPubChem	0.785	196.106
selenomethioninePubChem	0.785	196.106
2ohvPubChem	0.7	287.31
sulfatePubChem	0.7	96.0626
hydron sulfatePubChem	0.7	196.157