SInCRe - Rv1336

Tuberculist information

Gene name	cysM
Protein function	Cysteine synthase B CysM (CSASE B) (O-phosphoserine sulfhydrylase B) (O-phosphoserine (thiol)-lyase B)
Functional category(tuberculist)	intermediary metabolism and respiration
Gene location(kb)	1503.39
Molecular mass(da)	34438
External sites	TB Database TubercuList WebTB

Protein sequence

Number of amino acids : 323

	  		  	1    MTRYDSLLQALGNTPLVGLQRLSPRWDDGRDGPHVRLWAKLEDRNPTGSIKDRPAVRMIE   60
			  	61   QAEADGLLRPGATILEPTSGNTGISLAMAARLKGYRLICVMPENTSVERRQLLELYGAQI  120
			  	121  IFSAAEGGSNTAVATAKELAATNPSWVMLYQYGNPANTDSHYCGTGPELLADLPEITHFV  180
			  	181  AGLGTTGTLMGTGRFLREHVANVKIVAAEPRYGEGVYALRNMDEGFVPELYDPEILTARY  240
			  	241  SVGAVDAVRRTRELVHTEGIFAGISTGAVLHAALGVGAGALAAGERADIALVVADAGWKY  300
			  	301  LSTGAYAGSLDDAETALEGQLWA

Known structures in the PDB

	PDB ID	3DKI
	Total residue count	652
	Number of chains	2
	Method	X-RAY
	Resolution	2.1

	PDB ID	3DWG
	Total residue count	743
	Number of chains	3
	Method	X-RAY
	Resolution	1.53

	PDB ID	3DWI
	Total residue count	646
	Number of chains	2
	Method	X-RAY
	Resolution	2.81

	PDB ID	3FGP
	Total residue count	652
	Number of chains	2
	Method	X-RAY
	Resolution	2.05

Number of amino acids : 323

Domains assigned based on sequence.

Mtb Structural proteome models

CHOPIN models

Profile-based domain assignment

Structural/Functional domain family	Pfam acc.no./SCOP ID	Domain Region
PALP	PF00291	7-295

Mtb Structural Proteome models

Model Number	1
Model name	Rv1336
Template	2BHT APDB CREDO
Template coverage	3_292
Template Identity(%)	42.2
Model coverage(%)	92.9
Normalized DOPE score	-0.361

Structure Models from Chopin

Model Number	1
Profile	c.79.1.1 Click for model details
zscore	26.94
Residue begin	1
Residue end	323

Model Number	2
Profile	3.40.50.1100 Click for model details
zscore	11.54
Residue begin	77
Residue end	311

Binding pockets

STRING

Cytoscape Web will replace the contents of this div with protein-protein interaction network.

Protein interacting with Rv1336	Gene name	Confidence Score
Rv2335	cysE	0.999
Rv1335	cysO	0.999
Rv2335	cysE	0.999
Rv1334	mec	0.997
Rv3340	metC	0.969
Rv3206c	moeB1	0.967
Rv3206c	moeB1	0.967
Rv3206c	moeB1	0.967
Rv0848	cysK2	0.945
Rv1286	cysN	0.937
Rv1286	cysN	0.937
Rv1286	cysN	0.937
Rv2334	cysK1	0.929
Rv0075	Rv0075	0.927
Rv1337	Rv1337	0.927
Rv1338	murI	0.921
Rv2294	Rv2294	0.911

Potential ligand/drug binding sites

No binding sites identified

Similarity to known drug target from sensitive sequence analysis

No drug targets

List of small molecules tested from TIBLE

Data not available

Off-target activity - ligand based from TIBLE

Data not available

Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.

Data not available

STITCH interactions

Chemical Name	Confidence score	Molecular Weight
O-acetylserinePubChem	0.989	147.129
pyridoxal phosphatePubChem	0.975	247.142
O-acetyl-L-serinePubChem	0.972	147.129
sulphurPubChem	0.969	34.0809
sulfatePubChem	0.969	96.0626
half-cystinePubChem	0.943	121.158
L-serinePubChem	0.939	105.093
hydron sulfatePubChem	0.935	196.157
Nchembio861-comp5PubChem	0.932	377.33
acetyl-CoAPubChem	0.925	809.571
acetatePubChem	0.918	59.044
bisulfitePubChem	0.913	80.0632
cysteinatePubChem	0.907	121.158
Na(+)PubChem	0.906	22.9898
NADPPubChem	0.9	744.413
DL-serinePubChem	0.9	105.093
coenzyme APubChem	0.9	767.534
hydroxyl radicalsPubChem	0.9	17.0073
Co-APubChem	0.9	767.534
protiumPubChem	0.9	2.01576
deuteriumPubChem	0.9	2.01588
NADP(H)PubChem	0.9	745.421
H(+)PubChem	0.9	2.01588
L-selenocysteinePubChem	0.9	168.053
acetyl coenzyme-APubChem	0.9	809.571
aminoacrylatePubChem	0.741	87.0773