Rv0075

Tuberculist information
Gene nameRv0075
Protein functionProbable aminotransferase
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)83.996
Molecular mass(da)42766
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 390
	  		  	1    MQDSIFNLLTEEQLRGRNTLKWNYFGPDVVPLWLAEMDFPTAPAVLDGVRACVDNEEFGY   60
			  	61   PPLGEDSLPRATADWCRQRYGWCPRPDWVRVVPDVLKGMEVVVEFLTRPESPVALPVPAY  120
			  	121  MPFFDVLHVTGRQRVEVPMVQQDSGRYLLDLDALQAAFVRGAGSVIICNPNNPLGTAFTE  180
			  	181  AELRAIVDIAARHGARVIADEIWAPVVYGSRHVAAASVSEAAAEVVVTLVSASKGWNLPG  240
			  	241  LMCAQVILSNRRDAHDWDRINMLHRMGASTVGIRANIAAYHHGESWLDELLPYLRANRDH  300
			  	301  LARALPELAPGVEVNAPDGTYLSWVDFRALALPSEPAEYLLSKAKVALSPGIPFGAAVGS  360
			  	361  GFARLNFATTRAILDRAIEAIAAALRDIID

Known structures in the PDB
No Known structures
1 40 79 118 157 196 235 274 313 352 391 Range: 40 to 381  |  Coverage: 87% Aminotran_1_2 Range: 29 to 388  |  Coverage: 92% 1 Range: 1 to 390  |  Coverage: 99% 1
Number of amino acids : 390
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Aminotran_1_2PF0015540-381
Mtb Structural Proteome models
Model Number1
Model nameRv0075
Template1D2F    APDBCREDO
Template coverage30_389
Template Identity(%)27.8
Model coverage(%)92.1
Normalized DOPE score-0.554

Structure Models from Chopin
Model Number1
Profilec.67.1.3
Click for model details
zscore23.01
Residue begin1
Residue end390
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0075Gene nameConfidence Score
Rv2334cysK10.963
Rv1079metB0.949
Rv3340metC0.934
Rv1336cysM0.927
Rv0391metZ0.926
Rv1133cmetE0.924
Rv1133cmetE0.924
Rv2220glnA10.923
Rv2220glnA10.923
Rv2222cglnA20.922
Rv2222cglnA20.922
Rv1538cansA0.913
Rv2124cmetH0.904
Rv2124cmetH0.904
Rv2124cmetH0.904
Rv2124cmetH0.904
Rv2124cmetH0.904
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
pyridoxal phosphatePubChem0.809247.142
Nchembio861-comp5PubChem0.721377.33
SeMetPubChem0.721196.106
selenomethioninePubChem0.721196.106