SInCRe - Rv0391

Tuberculist information

Gene name	metZ
Protein function	Probable O-succinylhomoserine sulfhydrylase MetZ (OSH sulfhydrylase)
Functional category(tuberculist)	intermediary metabolism and respiration
Gene location(kb)	470.01
Molecular mass(da)	43345.2
External sites	TB Database TubercuList WebTB

Protein sequence

Number of amino acids : 406

	  		  	1    MTDESSVRTPKALPDGVSQATVGVRGGMLRSGFEETAEAMYLTSGYVYGSAAVAEKSFAG   60
			  	61   ELDHYVYSRYGNPTVSVFEERLRLIEGAPAAFATASGMAAVFTSLGALLGAGDRLVAARS  120
			  	121  LFGSCFVVCSEILPRWGVQTVFVDGDDLSQWERALSVPTQAVFFETPSNPMQSLVDIAAV  180
			  	181  TELAHAAGAKVVLDNVFATPLLQQGFPLGVDVVVYSGTKHIDGQGRVLGGAILGDREYID  240
			  	241  GPVQKLMRHTGPAMSAFNAWVLLKGLETLAIRVQHSNASAQRIAEFLNGHPSVRWVRYPY  300
			  	301  LPSHPQYDLAKRQMSGGGTVVTFALDCPEDVAKQRAFEVLDKMRLIDISNNLGDAKSLVT  360
			  	361  HPATTTHRAMGPEGRAAIGLGDGVVRISVGLEDTDDLIADIDRALS

Known structures in the PDB

	PDB ID	3NDN
	Total residue count	1656
	Number of chains	4
	Method	X-RAY
	Resolution	1.85

Number of amino acids : 406

Domains assigned based on sequence.

Mtb Structural proteome models

CHOPIN models

Profile-based domain assignment

Structural/Functional domain family	Pfam acc.no./SCOP ID	Domain Region
Cys_Met_Meta_PP	PF01053	20-406

Mtb Structural Proteome models

Model Number	1
Model name	Rv0391_3ndn_A
Template	3NDN APDB CREDO
Template coverage	6_406
Template Identity(%)	100.0
Model coverage(%)	98.5
Normalized DOPE score	-1.072

Model Number	2
Model name	Rv0391
Template	1Y4I APDB CREDO
Template coverage	11_393
Template Identity(%)	39.8
Model coverage(%)	94.6
Normalized DOPE score	-0.527

Structure Models from Chopin

Model Number	1
Profile	c.67.1.3 Click for model details
zscore	39.01
Residue begin	1
Residue end	406

Binding pockets

STRING

Cytoscape Web will replace the contents of this div with protein-protein interaction network.

Protein interacting with Rv0391	Gene name	Confidence Score
Rv3341	metA	0.998
Rv1133c	metE	0.975
Rv1133c	metE	0.975
Rv1077	cbs	0.958
Rv1077	cbs	0.958
Rv1079	metB	0.952
Rv2124c	metH	0.95
Rv2124c	metH	0.95
Rv2124c	metH	0.95
Rv2124c	metH	0.95
Rv2124c	metH	0.95
Rv3340	metC	0.949
Rv3248c	sahH	0.93
Rv3248c	sahH	0.93
Rv0075	Rv0075	0.926
Rv2458	mmuM	0.925
Rv1294	thrA	0.918
Rv1294	thrA	0.918
Rv1294	thrA	0.918
Rv2294	Rv2294	0.918
Rv1296	thrB	0.902
Rv1296	thrB	0.902

Potential ligand/drug binding sites

No binding sites identified

Similarity to known drug target from sensitive sequence analysis

No drug targets

List of small molecules tested from TIBLE

Data not available

Off-target activity - ligand based from TIBLE

Data not available

Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.

Data not available

STITCH interactions

Chemical Name	Confidence score	Molecular Weight
cystathioninePubChem	0.965	222.262
O-succinylhomoserinePubChem	0.955	219.192
homocysteinePubChem	0.954	135.185
homoserinePubChem	0.945	119.119
L-homocysteinePubChem	0.938	135.185
Nchembio861-comp5PubChem	0.937	377.33
sulphurPubChem	0.935	34.0809
L-methioninePubChem	0.93	149.211
half-cystinePubChem	0.927	121.158
L-cystathioninePubChem	0.926	222.262
O-acetyl-L-homoserinePubChem	0.917	161.156
L-homoserinePubChem	0.916	119.119
methyltetrahydrofolatePubChem	0.915	459.456
5-methyltetrahydrofolatePubChem	0.912	459.456
L-serinePubChem	0.911	105.093
cysteinatePubChem	0.907	121.158
acetyl-CoAPubChem	0.906	809.571
deuteriumPubChem	0.902	2.01588
tetrahydropteroyltriglutamatePubChem	0.9	703.657
NADP(H)PubChem	0.9	745.421
protiumPubChem	0.9	2.01576
H(+)PubChem	0.9	2.01588
hydroxyl radicalsPubChem	0.9	17.0073
Co-APubChem	0.9	767.534
tetrahydrofolatePubChem	0.9	445.429
C04489PubChem	0.9	717.684
acetyl coenzyme-APubChem	0.9	809.571
NADPPubChem	0.9	744.413
H4FPubChem	0.9	445.429
DL-serinePubChem	0.9	105.093
C04144PubChem	0.9	703.657
bisulfitePubChem	0.9	80.0632
acetatePubChem	0.9	59.044
coenzyme APubChem	0.9	767.534