Rv1296

Tuberculist information
Gene namethrB
Protein functionProbable homoserine kinase ThrB
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)1452
Molecular mass(da)32346.4
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 316
	  		  	1    MVTQALLPSGLVASAVVAASSANLGPGFDSVGLALSLYDEIIVETTDSGLTVTVDGEGGD   60
			  	61   QVPLGPEHLVVRAVQHGLQAAGVSAAGLAVRCRNAIPHSRGLGSSAAAVVGGLAAVNGLV  120
			  	121  VQTDSSPSSDAELIQLASEFEGHPDNAAAAVLGGAVVSWTDHSGDRPNYSAVSLRLHPDI  180
			  	181  RLFTAIPEQRSSTAETRVLLPAQVSHDDARFNVSRAALLVVALTERPDLLMAATEDLLHQ  240
			  	241  PQRAAAMTASAEYLRLLRRHNVAAALSGAGPSLIALSTDSELPTDAVEFGAAKGFAVTEL  300
			  	301  TVGEAVRWSPTVRVPG

Known structures in the PDB
No Known structures
1 32 63 94 125 156 187 218 249 280 311 Range: 89 to 154  |  Coverage: 20% GHMP_kinases_N Range: 219 to 296  |  Coverage: 24% GHMP_kinases_C Range: 11 to 309  |  Coverage: 94% 1 Range: 11 to 315  |  Coverage: 96% 1 Range: 178 to 310  |  Coverage: 41% 2 Range: 89 to 154  |  Coverage: 20% 3
Number of amino acids : 316
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
GHMP_kinases_NPF0028889-154
GHMP_kinases_CPF08544219-296
Mtb Structural Proteome models
Model Number1
Model nameRv1296
Template1H72    CPDBCREDO
Template coverage5_300
Template Identity(%)25.0
Model coverage(%)94.3
Normalized DOPE score0.127

Structure Models from Chopin
Model Number1
Profiled.14.1.5, d.58.26.1 - 3.30.230.10, 3.30.70.890
Click for model details
zscore46.59
Residue begin11
Residue end315
Model Number2
Profiled.58.26.1
Click for model details
zscore20.75
Residue begin178
Residue end310
Model Number3
Profiled.14.1.5
Click for model details
zscore9.34
Residue begin89
Residue end154
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1296Gene nameConfidence Score
Rv1294thrA0.999
Rv1294thrA0.999
Rv1294thrA0.999
Rv1295thrC0.997
Rv1293lysA0.983
Rv1293lysA0.983
Rv3708casd0.964
Rv3708casd0.964
Rv3709cask0.943
Rv3709cask0.943
Rv3709cask0.943
Rv1079metB0.942
Rv0391metZ0.902
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
homoserinePubChem0.99119.119
L-threoninePubChem0.982119.119
L-homoserinePubChem0.979119.119
adenosine diphosphatePubChem0.956427.201
L-aspartate-beta-semialdehydePubChem0.947117.103
O-phosphohomoserinePubChem0.926199.099
phosphatePubChem0.91996.9872
cystathioninePubChem0.906222.262
adenosine triphosphatePubChem0.904507.181
deuteriumPubChem0.92.01588
L-cystathioninePubChem0.9222.262
cysteinatePubChem0.9121.158
hydroxyl radicalsPubChem0.917.0073
O-PhosphorylhomoserinePubChem0.9199.099
L-allo-threoninePubChem0.9119.119
protiumPubChem0.92.01576
H(+)PubChem0.92.01588
half-cystinePubChem0.9121.158
L-isoleucinePubChem0.816131.173
L-methioninePubChem0.771149.211