SInCRe - Rv1294

Tuberculist information

Gene name	thrA
Protein function	Probable homoserine dehydrogenase ThrA
Functional category(tuberculist)	intermediary metabolism and respiration
Gene location(kb)	1449.38
Molecular mass(da)	45520.7
External sites	TB Database TubercuList WebTB

Protein sequence

Number of amino acids : 441

	  		  	1    VPGDEKPVGVAVLGLGNVGSEVVRIIENSAEDLAARVGAPLVLRGIGVRRVTTDRGVPIE   60
			  	61   LLTDDIEELVAREDVDIVVEVMGPVEPSRKAILGALERGKSVVTANKALLATSTGELAQA  120
			  	121  AESAHVDLYFEAAVAGAIPVIRPLTQSLAGDTVLRVAGIVNGTTNYILSAMDSTGADYAS  180
			  	181  ALADASALGYAEADPTADVEGYDAAAKAAILASIAFHTRVTADDVYREGITKVTPADFGS  240
			  	241  AHALGCTIKLLSICERITTDEGSQRVSARVYPALVPLSHPLAAVNGAFNAVVVEAEAAGR  300
			  	301  LMFYGQGAGGAPTASAVTGDLVMAARNRVLGSRGPRESKYAQLPVAPMGFIETRYYVSMN  360
			  	361  VADKPGVLSAVAAEFAKREVSIAEVRQEGVVDEGGRRVGARIVVVTHLATDAALSETVDA  420
			  	421  LDDLDVVQGVSSVIRLEGTGL

Known structures in the PDB

No Known structures

Number of amino acids : 441

Domains assigned based on sequence.

Mtb Structural proteome models

CHOPIN models

Profile-based domain assignment

Structural/Functional domain family	Pfam acc.no./SCOP ID	Domain Region
NAD_binding_3	PF03447	14-131
Homoserine_dh	PF00742	139-322
ACT	PF01842	355-426

Mtb Structural Proteome models

Model Number	1
Model name	Rv1294
Template	1EBF APDB CREDO
Template coverage	2_359
Template Identity(%)	24.3
Model coverage(%)	73.5
Normalized DOPE score	0.513

Structure Models from Chopin

Model Number	1
Profile	d.81.1.2 Click for model details
zscore	22.4
Residue begin	139
Residue end	309

Model Number	2
Profile	d.58.18.3 Click for model details
zscore	8.09
Residue begin	355
Residue end	434

Binding pockets

STRING

Cytoscape Web will replace the contents of this div with protein-protein interaction network.

Protein interacting with Rv1294	Gene name	Confidence Score
Rv1296	thrB	0.999
Rv1296	thrB	0.999
Rv3709c	ask	0.998
Rv3709c	ask	0.998
Rv1295	thrC	0.998
Rv3709c	ask	0.998
Rv3708c	asd	0.997
Rv3708c	asd	0.997
Rv1293	lysA	0.995
Rv1293	lysA	0.995
Rv3341	metA	0.994
Rv2753c	dapA	0.981
Rv3340	metC	0.969
Rv3248c	sahH	0.956
Rv3248c	sahH	0.956
Rv2335	cysE	0.951
Rv2335	cysE	0.951
Rv1599	hisD	0.946
Rv2124c	metH	0.944
Rv2124c	metH	0.944
Rv2124c	metH	0.944
Rv2124c	metH	0.944
Rv2124c	metH	0.944
Rv1133c	metE	0.943
Rv1133c	metE	0.943
Rv1079	metB	0.938
Rv1292	argS	0.925
Rv1292	argS	0.925
Rv1292	argS	0.925
Rv0391	metZ	0.918

Potential ligand/drug binding sites

No binding sites identified

Similarity to known drug target from sensitive sequence analysis

No drug targets

List of small molecules tested from TIBLE

Data not available

Off-target activity - ligand based from TIBLE

Data not available

Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.

Data not available

STITCH interactions

Chemical Name	Confidence score	Molecular Weight
homoserinePubChem	0.987	119.119
L-aspartate-beta-semialdehydePubChem	0.97	117.103
phosphatePubChem	0.967	96.9872
O-phosphohomoserinePubChem	0.946	199.099
NADPPubChem	0.94	744.413
succinyl-CoAPubChem	0.939	867.607
NADP(H)PubChem	0.926	745.421
coenzyme APubChem	0.91	767.534
acetyl-CoAPubChem	0.909	809.571
L-homoserinePubChem	0.908	119.119
acetyl coenzyme-APubChem	0.9	809.571
protiumPubChem	0.9	2.01576
O-PhosphorylhomoserinePubChem	0.9	199.099
suc-coaPubChem	0.9	867.607
aspartyl phosphatePubChem	0.9	213.083
Co-APubChem	0.9	767.534
beta-aspartyl phosphatePubChem	0.9	213.083
O-acetyl-L-homoserinePubChem	0.9	161.156
H(+)PubChem	0.9	2.01588
deuteriumPubChem	0.9	2.01588
succinyl-homoserinePubChem	0.9	219.192
O-succinylhomoserinePubChem	0.9	219.192
adenosine diphosphatePubChem	0.9	427.201
adenosine triphosphatePubChem	0.9	507.181
L-methioninePubChem	0.897	149.211
selenomethioninePubChem	0.792	196.106
SeMetPubChem	0.792	196.106
L-threoninePubChem	0.786	119.119
aspartatePubChem	0.759	133.103
L-lysinePubChem	0.743	146.188
L-isoleucinePubChem	0.737	131.173
sulfatePubChem	0.733	96.0626
hydron sulfatePubChem	0.733	196.157