Rv3341

Tuberculist information
Gene namemetA
Protein functionProbable homoserine O-acetyltransferase MetA (homoserine O-trans-acetylase) (homoserine transacetylase) (HTA)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)3727.49
Molecular mass(da)39768.8
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 379
	  		  	1    MTISDVPTQTLPAEGEIGLIDVGSLQLESGAVIDDVCIAVQRWGKLSPARDNVVVVLHAL   60
			  	61   TGDSHITGPAGPGHPTPGWWDGVAGPGAPIDTTRWCAVATNVLGGCRGSTGPSSLARDGK  120
			  	121  PWGSRFPLISIRDQVQADVAALAALGITEVAAVVGGSMGGARALEWVVGYPDRVRAGLLL  180
			  	181  AVGARATADQIGTQTTQIAAIKADPDWQSGDYHETGRAPDAGLRLARRFAHLTYRGEIEL  240
			  	241  DTRFANHNQGNEDPTAGGRYAVQSYLEHQGDKLLSRFDAGSYVILTEALNSHDVGRGRGG  300
			  	301  VSAALRACPVPVVVGGITSDRLYPLRLQQELADLLPGCAGLRVVESVYGHDGFLVETEAV  360
			  	361  GELIRQTLGLADREGACRR

Known structures in the PDB
No Known structures
1 38 75 112 149 186 223 260 297 334 371 Range: 69 to 366  |  Coverage: 78% Abhydrolase_1 Range: 19 to 368  |  Coverage: 92% 1 Range: 7 to 374  |  Coverage: 96% 1
Number of amino acids : 379
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Abhydrolase_1PF0056169-366
Mtb Structural Proteome models
Model Number1
Model nameRv3341
Template2B61    APDBCREDO
Template coverage8_355
Template Identity(%)37.4
Model coverage(%)92.1
Normalized DOPE score-0.73

Structure Models from Chopin
Model Number1
Profilec.69.1.40
Click for model details
zscore75.97
Residue begin7
Residue end374
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3341Gene nameConfidence Score
Rv3340metC0.999
Rv0391metZ0.998
Rv1079metB0.994
Rv1294thrA0.994
Rv1294thrA0.994
Rv1294thrA0.994
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
homoserinePubChem0.977119.119
homocysteinePubChem0.958135.185
acetyl-CoAPubChem0.956809.571
L-homoserinePubChem0.954119.119
L-homocysteinePubChem0.954135.185
O-acetyl-L-homoserinePubChem0.941161.156
sulphurPubChem0.91634.0809
acetatePubChem0.90259.044
L-aspartate-beta-semialdehydePubChem0.9117.103
acetyl coenzyme-APubChem0.9809.571
deuteriumPubChem0.92.01588
coenzyme APubChem0.9767.534
H(+)PubChem0.92.01588
Co-APubChem0.9767.534
protiumPubChem0.92.01576