SInCRe - Rv3340

Tuberculist information

Gene name	metC
Protein function	Probable O-acetylhomoserine sulfhydrylase MetC (homocysteine synthase) (O-acetylhomoserine (thiol)-lyase) (OAH sulfhydrylase) (O-acetyl-L-homoserine sulfhydrylase)
Functional category(tuberculist)	intermediary metabolism and respiration
Gene location(kb)	3726.13
Molecular mass(da)	47371.2
External sites	TB Database TubercuList WebTB

Protein sequence

Number of amino acids : 449

	  		  	1    MSADSNSTDADPTAHWSFETKQIHAGQHPDPTTNARALPIYATTSYTFDDTAHAAALFGL   60
			  	61   EIPGNIYTRIGNPTTDVVEQRIAALEGGVAALFLSSGQAAETFAILNLAGAGDHIVSSPR  120
			  	121  LYGGTYNLFHYSLAKLGIEVSFVDDPDDLDTWQAAVRPNTKAFFAETISNPQIDLLDTPA  180
			  	181  VSEVAHRNGVPLIVDNTIATPYLIQPLAQGADIVVHSATKYLGGHGAAIAGVIVDGGNFD  240
			  	241  WTQGRFPGFTTPDPSYHGVVFAELGPPAFALKARVQLLRDYGSAASPFNAFLVAQGLETL  300
			  	301  SLRIERHVANAQRVAEFLAARDDVLSVNYAGLPSSPWHERAKRLAPKGTGAVLSFELAGG  360
			  	361  IEAGKAFVNALKLHSHVANIGDVRSLVIHPASTTHAQLSPAEQLATGVSPGLVRLAVGIE  420
			  	421  GIDDILADLELGFAAARRFSADPQSVAAF

Known structures in the PDB

No Known structures

Number of amino acids : 449

Domains assigned based on sequence.

Mtb Structural proteome models

CHOPIN models

Profile-based domain assignment

Structural/Functional domain family	Pfam acc.no./SCOP ID	Domain Region
Cys_Met_Meta_PP	PF01053	19-434

Mtb Structural Proteome models

Model Number	1
Model name	Rv3340
Template	2CTZ APDB CREDO
Template coverage	2_421
Template Identity(%)	53.6
Model coverage(%)	92.9
Normalized DOPE score	-0.707

Structure Models from Chopin

Model Number	1
Profile	c.67.1.3 Click for model details
zscore	28.62
Residue begin	1
Residue end	448

Binding pockets

STRING

Cytoscape Web will replace the contents of this div with protein-protein interaction network.

Protein interacting with Rv3340	Gene name	Confidence Score
Rv3341	metA	0.999
Rv2334	cysK1	0.989
Rv1133c	metE	0.988
Rv1133c	metE	0.988
Rv2335	cysE	0.977
Rv2335	cysE	0.977
Rv2124c	metH	0.972
Rv2124c	metH	0.972
Rv2124c	metH	0.972
Rv2124c	metH	0.972
Rv2124c	metH	0.972
Rv1294	thrA	0.969
Rv1294	thrA	0.969
Rv1077	cbs	0.969
Rv1294	thrA	0.969
Rv1077	cbs	0.969
Rv1336	cysM	0.969
Rv1079	metB	0.956
Rv3248c	sahH	0.953
Rv3248c	sahH	0.953
Rv0391	metZ	0.949
Rv2458	mmuM	0.948
Rv0075	Rv0075	0.934
Rv0848	cysK2	0.922
Rv2294	Rv2294	0.921

Potential ligand/drug binding sites

No binding sites identified

Similarity to known drug target from sensitive sequence analysis

No drug targets

List of small molecules tested from TIBLE

Data not available

Off-target activity - ligand based from TIBLE

Data not available

Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.

Data not available

STITCH interactions

Chemical Name	Confidence score	Molecular Weight
O-acetylserinePubChem	0.97	147.129
homocysteinePubChem	0.968	135.185
L-methioninePubChem	0.955	149.211
L-homocysteinePubChem	0.953	135.185
O-acetyl-L-homoserinePubChem	0.95	161.156
O-acetyl-L-serinePubChem	0.943	147.129
methanethiolPubChem	0.935	48.1075
half-cystinePubChem	0.933	121.158
deuteriumPubChem	0.901	2.01588
H(+)PubChem	0.9	2.01588
acetatePubChem	0.9	59.044
protiumPubChem	0.9	2.01576
cystathioninePubChem	0.788	222.262
pyridoxal phosphatePubChem	0.775	247.142
O-succinylhomoserinePubChem	0.719	219.192