Rv2294

Tuberculist information
Gene nameRv2294
Protein functionProbable aminotransferase
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)2565.33
Molecular mass(da)44251.1
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 407
	  		  	1    VIPNPLEELTLEQLRSQRTSMKWRAHPADVLPLWVAEMDVKLPPTVADALRRAIDDGDTG   60
			  	61   YPYGTEYAEAVREFACQRWQWHDLEVSRTAIVPDVMLGIVEVLRLITDRGDPVIVNSPVY  120
			  	121  APFYAFVSHDGRRVIPAPLRGDGRIDLDALQEAFSSARASSGSSGNVAYLLCNPHNPTGS  180
			  	181  VHTADELRGIAERAQRFGVRVVSDEIHAPLIPSGARFTPYLSVPGAENAFALMSASKAWN  240
			  	241  LGGLKAALAIAGREAAADLARMPEEVGHGPSHLGVIAHTAAFRTGGNWLDALLRGLDHNR  300
			  	301  TLLGALVDEHLPGVQYRWPQGTYLAWLDCRELGFDDAASDEMTEGLAVVSDLSGPARWFL  360
			  	361  DHARVALSSGHVFGIGGAGHVRINFATSRAILIEAVSRMSRSLLERR

Known structures in the PDB
No Known structures
1 41 81 121 161 201 241 281 321 361 401 Range: 29 to 399  |  Coverage: 90% Aminotran_1_2 Range: 15 to 407  |  Coverage: 96% 1 Range: 1 to 407  |  Coverage: 99% 1
Number of amino acids : 407
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Aminotran_1_2PF0015529-399
Mtb Structural Proteome models
Model Number1
Model nameRv2294
Template1C7N    APDBCREDO
Template coverage11_394
Template Identity(%)28.6
Model coverage(%)96.3
Normalized DOPE score-0.513

Structure Models from Chopin
Model Number1
Profilec.67.1.3
Click for model details
zscore25.47
Residue begin1
Residue end407
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2294Gene nameConfidence Score
Rv2334cysK10.938
Rv1079metB0.936
Rv3340metC0.921
Rv0391metZ0.918
Rv2222cglnA20.914
Rv2222cglnA20.914
Rv1336cysM0.911
Rv2220glnA10.91
Rv2220glnA10.91
Rv1133cmetE0.908
Rv1133cmetE0.908
Rv1538cansA0.905
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
pyridoxal phosphatePubChem0.714247.142