SInCRe - Rv1538c

Tuberculist information

Gene name	ansA
Protein function	Probable L-aparaginase AnsA
Functional category(tuberculist)	intermediary metabolism and respiration
Gene location(kb)	1741.21
Molecular mass(da)	32946.5
External sites	TB Database TubercuList WebTB

Protein sequence

Number of amino acids : 326

	  		  	1    MGANHVRNDPIMARLTVITTGGTISTTAGPDGVLRPTHCGATLIAGLDMDSDIEVVDLMA   60
			  	61   LDSSKLTPADWDRIGAAVQEAFRGGADGVVITHGTDTLEETALWLDLTYAGSRPVVLTGA  120
			  	121  MLSADAPGADGPANLRDALAVAADPAARDLGVLVSFGGRVLQPLGLHKVANPDLCGFAGE  180
			  	181  SLGFTSGGVRLTRTKTRPYLGDLGAAVAPRVDIVAVYPGSDAVAMDACVAAGARAVVLEA  240
			  	241  LGSGNAGAAVIEGVRRHCRDGSDPVVIAVSTRVAGARVGAGYGPGHDLVEAGAVMVPRLP  300
			  	301  PSQARVLLMAALAANSPVADVIDRWG

Known structures in the PDB

No Known structures

Number of amino acids : 326

Domains assigned based on sequence.

Mtb Structural proteome models

CHOPIN models

Profile-based domain assignment

Structural/Functional domain family	Pfam acc.no./SCOP ID	Domain Region
Asparaginase	PF00710	3-310

Mtb Structural Proteome models

Model Number	1
Model name	Rv1538c
Template	1NNS APDB CREDO
Template coverage	1_321
Template Identity(%)	29.2
Model coverage(%)	95.4
Normalized DOPE score	-0.485

Structure Models from Chopin

Model Number	1
Profile	c.88.1.1 Click for model details
zscore	44.61
Residue begin	1
Residue end	326

Model Number	2
Profile	3.40.50.1170 Click for model details
zscore	35.07
Residue begin	11
Residue end	214

Model Number	3
Profile	3.40.50.40 Click for model details
zscore	14.19
Residue begin	208
Residue end	326

Binding pockets

STRING

Cytoscape Web will replace the contents of this div with protein-protein interaction network.

Protein interacting with Rv1538c	Gene name	Confidence Score
Rv0252	nirB	0.952
Rv0252	nirB	0.952
Rv0252	nirB	0.952
Rv0252	nirB	0.952
Rv0252	nirB	0.952
Rv1540	Rv1540	0.944
Rv1540	Rv1540	0.944
Rv2220	glnA1	0.941
Rv2220	glnA1	0.941
Rv2222c	glnA2	0.935
Rv2222c	glnA2	0.935
Rv1658	argG	0.928
Rv1380	pyrB	0.922
Rv1380	pyrB	0.922
Rv0075	Rv0075	0.913
Rv2476c	gdh	0.913
Rv0357c	purA	0.91
Rv1595	nadB	0.906
Rv1595	nadB	0.906
Rv0253	nirD	0.905
Rv2294	Rv2294	0.905

Potential ligand/drug binding sites

No binding sites identified

Similarity to known drug target from sensitive sequence analysis

No drug targets

List of small molecules tested from TIBLE

Data not available

Off-target activity - ligand based from TIBLE

Data not available

Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.

Data not available

STITCH interactions

Chemical Name	Confidence score	Molecular Weight
L-asparaginePubChem	0.989	132.118
aspartatePubChem	0.989	133.103
ammoniaPubChem	0.955	17.0305
ASPARAGINEPubChem	0.947	132.118
deuteriumPubChem	0.9	2.01588
protiumPubChem	0.9	2.01576
H(+)PubChem	0.9	2.01588
hydroxyl radicalsPubChem	0.9	17.0073
potassium aspartatePubChem	0.9	133.103
D-asparaginePubChem	0.805	132.118
SeMetPubChem	0.781	196.106
selenomethioninePubChem	0.781	196.106
glycerolPubChem	0.747	92.0938
acetatePubChem	0.714	59.044
hydride acetatePubChem	0.714	61.0599