Rv0252

Tuberculist information
Gene namenirB
Protein functionProbable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)302.866
Molecular mass(da)90352.6
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 853
	  		  	1    MPTAGSSRAPAAAREIVVVGHGMVGHRLVEAVRARDADGSLRITVLAEEGDAAYDRVGLT   60
			  	61   SYTESWDRALLALPGNDYAGDQRVRLLLNTRVTQIDRATKSVVTAAGQRHRYDTLVLATG  120
			  	121  SYAFVPPVPGHDLPACHVYRTFDDLDAIRAGAQRTLDGGHTDGGVVIGGGLLGLEAANAL  180
			  	181  RQFGLQTHVVEMMPRLMAQQIDEAGGALLARMIADLGIAVHVGTGTESIESVKHSDGSVW  240
			  	241  ARVRLSDGEVIDAGVVIFAAGIRPRDELARAAGLAIGDRGGVLTDLSCRTSDPDIYAVGE  300
			  	301  VAAIDGRCYGLVGPGYTSAEVVADRLLDGSAEFPEADLSTKLKLLGVDVASFGDAMGATE  360
			  	361  NCLEVVINDAVKRTYAKLVLSDDATTLLGGVLVGDASSYGVLRPMVGAELPGDPLALIAP  420
			  	421  AGSGAGAGALGVGALPDSAQICSCNNVTKGELKCAIADGCGDVPALKSCTAAGTSCGSCV  480
			  	481  PLLKQLLEAEGVEQSKALCEHFSQSRAELFEIITATEVRTFSGLLDRFGRGKGCDICKPV  540
			  	541  VASILASTGSDHILDGEQASLQDSNDHFLANIQKNGSYSVVPRVPGGDIKPEHLILIGQI  600
			  	601  AQDFGLYTKITGGQRIDLFGARVDQLPLIWQRLVDGGMESGHAYGKAVRTVKSCVGSDWC  660
			  	661  RYGQQDSVQLAIDLELRYRGLRAPHKIKLGVSGCARECAEARGKDVGVIATEKGWNLYVA  720
			  	721  GNGGMTPKHAQLLASDLDKETLIRYIDRFLIYYIRTADRLQRTAPWVESLGLDHVREVVC  780
			  	781  EDSLGLAEEFEAAMQRHVANYKCEWKGVLEDPDKLSRFVSFVNAPDAVDSTVTFTERAGR  840
			  	841  KVPVSIGIPRVRS

Known structures in the PDB
No Known structures
1 86 171 256 341 426 511 596 681 766 851 Range: 15 to 156  |  Coverage: 16% Pyr_redox_2 Range: 164 to 248  |  Coverage: 9% Pyr_redox Range: 222 to 306  |  Coverage: 9% Pyr_redox_2 Range: 439 to 491  |  Coverage: 6% Fer2_BFD Range: 571 to 635  |  Coverage: 7% NIR_SIR_ferr Range: 644 to 787  |  Coverage: 16% NIR_SIR Range: 11 to 456  |  Coverage: 52% 1 Range: 644 to 787  |  Coverage: 16% 1
Number of amino acids : 853
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Pyr_redox_2PF0799215-156
Pyr_redoxPF00070164-248
Pyr_redox_2PF07992222-306
Fer2_BFDPF04324439-491
NIR_SIR_ferrPF03460571-635
NIR_SIRPF01077644-787
Mtb Structural Proteome models
Model Number1
Model nameRv0252
Template2CFY    APDBCREDO
Template coverage10_493
Template Identity(%)16.8
Model coverage(%)52.2
Normalized DOPE score0.926

Structure Models from Chopin
Model Number1
Profiled.134.1.1
Click for model details
zscore22.59
Residue begin644
Residue end787
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0252Gene nameConfidence Score
Rv0253nirD0.999
Rv1161narG0.99
Rv1161narG0.99
Rv1161narG0.99
Rv1162narH0.989
Rv1162narH0.989
Rv1164narI0.98
Rv1163narJ0.977
Rv2847ccysG0.956
Rv2847ccysG0.956
Rv1538cansA0.952
Rv2220glnA10.951
Rv2220glnA10.951
Rv1737cnarK20.943
Rv2222cglnA20.933
Rv2222cglnA20.933
Rv2860cglnA40.93
Rv2860cglnA40.93
Rv1878glnA30.925
Rv2476cgdh0.904
Rv1736cnarX0.903
Rv1736cnarX0.903
Rv1736cnarX0.903
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
ammoniaPubChem0.97217.0305
nitrous acidPubChem0.90846.0055
hydroxyl radicalsPubChem0.917.0073
protiumPubChem0.92.01576
deuteriumPubChem0.92.01588
reduced nicotinamide adenine dinucleotidePubChem0.9665.441
H(+)PubChem0.92.01588
nitrite ionPubChem0.946.0055
NAD+PubChem0.9663.425
dihydronicotinamide formycin dinucleotidePubChem0.9665.441
nitritePubChem0.84225.181
nitratePubChem0.83362.0049
sirohemePubChem0.733916.661