Rv1162

Tuberculist information
Gene namenarH
Protein functionProbable respiratory nitrate reductase (beta chain) NarH
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)1291.06
Molecular mass(da)62037.8
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 558
	  		  	1    MKVMAQMAMVMNLDKCIGCHTCSVTCKQAWTNRSGTEYVWFNNVETRPGVGYPRTYEDQE   60
			  	61   RWRGGWVRDKKGRLRLRDGGRIHKLLRIFANPKLPTIGDYYEPWTYDYENLTSAPAGDTF  120
			  	121  PTAAPRSLISGNPMKVSWGSNWDDNLAGSPEIVPNDPVLKKVNQVNQEVKLKLEETFMFY  180
			  	181  LPRICEHCLNPSCVASCPSGAMYKRTEDGIVLVDQDRCRGWRMCVSGCPYKKVYFNHKTG  240
			  	241  KAEKCTLCYPRIEVGLPTVCSETCVGRLRYLGLVLYDVDQVLQAASVESDTDLYEAQRRI  300
			  	301  LLDPHDPRVIAGARAEGIADEWIEAAQRSPVYALINTYRVALPLHPEYRTMPMVWYIPPL  360
			  	361  SPVVDAVSRDGHDGEDLGNLFGALDALRIPIAYLAELFTAGDTEVVAGVLRRLAAMRCYM  420
			  	421  RDINLGRETQPHIPESVGMTEEQIYQMYRLLAVAKYEERYVIPTSYAGELPAAAMTDDMG  480
			  	481  CSLSVDGGPGMYESGPFGQGSPTPVPIAVESFHALQHAGSAATGGAGRSRVNLLNWDPNG  540
			  	541  AAAGLFPEPQPSKDVVQR

Known structures in the PDB
No Known structures
1 56 111 166 221 276 331 386 441 496 551 Range: 176 to 274  |  Coverage: 17% Fer4_11 Range: 360 to 442  |  Coverage: 14% Nitr_red_bet_C Range: 1 to 513  |  Coverage: 91% 1 Range: 178 to 258  |  Coverage: 14% 1
Number of amino acids : 558
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Fer4_11PF13247176-274
Nitr_red_bet_CPF14711360-442
Mtb Structural Proteome models
Model Number1
Model nameRv1162
Template1Q16    BPDBCREDO
Template coverage1_509
Template Identity(%)52.5
Model coverage(%)91.8
Normalized DOPE score-0.287

Structure Models from Chopin
Model Number1
Profiled.58.1.1 - 3.30.70.20
Click for model details
zscore4.93
Residue begin178
Residue end258
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1162Gene nameConfidence Score
Rv1164narI0.999
Rv1161narG0.999
Rv1161narG0.999
Rv1161narG0.999
Rv1163narJ0.999
Rv0252nirB0.989
Rv0252nirB0.989
Rv0252nirB0.989
Rv0252nirB0.989
Rv0252nirB0.989
Rv0261cnarK30.953
Rv1737cnarK20.944
Rv0253nirD0.942
Rv2391sirA0.942
Rv2391sirA0.942
Rv0267narU0.936
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
nitratePubChem0.95962.0049
nitrite ionPubChem0.946.0055
nitrous acidPubChem0.946.0055