Rv0253

Tuberculist information
Gene namenirD
Protein functionProbable nitrite reductase [NAD(P)H] small subunit NirD
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)305.453
Molecular mass(da)12398.1
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 118
	  		  	1    VTLLNDIQVWTTACAYDHLIPGRGVGVLLDDGSQVALFRLDDGSVHAVGNVDPFSGAAVM   60
			  	61   SRGIVGDRGGRAMVQSPILKQAFALDDGSCLDDPRVSVPVYPARVTPEGRIQVARVAV

Known structures in the PDB
PDB ID4AIV
Total residue count119
Number of chains1
MethodX-RAY
Resolution2
1 12 23 34 45 56 67 78 89 100 111 Range: 9 to 114  |  Coverage: 88% Rieske_2 Range: 10 to 116  |  Coverage: 89% 1 Range: 7 to 118  |  Coverage: 94% 1
Number of amino acids : 118
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Rieske_2PF138069-114
Mtb Structural Proteome models
Model Number1
Model nameRv0253
Template1VCK    APDBCREDO
Template coverage5_105
Template Identity(%)23.8
Model coverage(%)89.8
Normalized DOPE score-0.373

Structure Models from Chopin
Model Number1
Profileb.33.1.3 - 2.102.10.10
Click for model details
zscore24.79
Residue begin7
Residue end118
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0253Gene nameConfidence Score
Rv0252nirB0.999
Rv0252nirB0.999
Rv0252nirB0.999
Rv0252nirB0.999
Rv0252nirB0.999
Rv1164narI0.945
Rv1161narG0.943
Rv1161narG0.943
Rv1163narJ0.943
Rv1161narG0.943
Rv1162narH0.942
Rv1162narH0.942
Rv1878glnA30.926
Rv2222cglnA20.924
Rv2222cglnA20.924
Rv2220glnA10.92
Rv2220glnA10.92
Rv1538cansA0.905
Rv2860cglnA40.904
Rv2860cglnA40.904
Rv2476cgdh0.901
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
reduced nicotinamide adenine dinucleotidePubChem0.9665.441
H(+)PubChem0.92.01588
hydroxyl radicalsPubChem0.917.0073
nitrite ionPubChem0.946.0055
ammoniaPubChem0.917.0305
NAD+PubChem0.9663.425
nitrous acidPubChem0.946.0055
dihydronicotinamide formycin dinucleotidePubChem0.9665.441
protiumPubChem0.92.01576
deuteriumPubChem0.92.01588