Rv2476c

Tuberculist information
Gene namegdh
Protein functionProbable NAD-dependent glutamate dehydrogenase Gdh (NAD-Gdh) (NAD-dependent glutamic dehydrogenase)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)2777.39
Molecular mass(da)176900
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 1624
	  		  	1    MTIDPGAKQDVEAWTTFTASADIPDWISKAYIDSYRGPRDDSSEATKAAEASWLPASLLT   60
			  	61   PAMLGAHYRLGRHRAAGESCVAVYRADDPAGFGPALQVVAEHGGMLMDSVTVLLHRLGIA  120
			  	121  YAAILTPVFDVHRSPTGELLRIEPKAEGTSPHLGEAWMHVALSPAVDHKGLAEVERLLPK  180
			  	181  VLADVQRVATDATALIATLSELAGEVESNAGGRFSAPDRQDVGELLRWLGDGNFLLLGYQ  240
			  	241  RCRVADGMVYGEGSSGMGVLRGRTGSRPRLTDDDKLLVLAQARVGSYLRYGAYPYAIAVR  300
			  	301  EYVDGSVVEHRFVGLFSVAAMNADVLEIPTISRRVREALAMAESDPSHPGQLLLDVIQTV  360
			  	361  PRPELFTLSAQRLLTMARAVVDLGSQRQALLFLRADRLQYFVSCLVYMPRDRYTTAVRMQ  420
			  	421  FEDILVREFGGTRLEFTARVSESPWALMHFMVRLPEVGVAGEGAAAPPVDVSEANRIRIQ  480
			  	481  GLLTEAARTWADRLIGAAAAAGSVGQADAMHYAAAFSEAYKQAVTPADAIGDIAVITELT  540
			  	541  DDSVKLVFSERDEQGVAQLTWFLGGRTASLSQLLPMLQSMGVVVLEERPFSVTRPDGLPV  600
			  	601  WIYQFKISPHPTIPLAPTVAERAATAHRFAEAVTAIWHGRVEIDRFNELVMRAGLTWQQV  660
			  	661  VLLRAYAKYLRQAGFPYSQSYIESVLNEHPATVRSLVDLFEALFVPVPSGSASNRDAQAA  720
			  	721  AAAVAADIDALVSLDTDRILRAFASLVQATLRTNYFVTRQGSARCRDVLALKLNAQLIDE  780
			  	781  LPLPRPRYEIFVYSPRVEGVHLRFGPVARGGLRWSDRRDDFRTEILGLVKAQAVKNAVIV  840
			  	841  PVGAKGGFVVKRPPLPTGDPAADRDATRAEGVACYQLFISGLLDVTDNVDHATASVNPPP  900
			  	901  EVVRRDGDDAYLVVAADKGTATFSDIANDVAKSYGFWLGDAFASGGSVGYDHKAMGITAR  960
			  	961  GAWEAVKRHFREIGIDTQTQDFTVVGIGDMSGDVFGNGMLLSKHIRLIAAFDHRHIFLDP 1020
			  	1021 NPDAAVSWAERRRMFELPRSSWSDYDRSLISEGGGVYSREQKAIPLSAQVRAVLGIDGSV 1080
			  	1081 DGGAAEMAPPNLIRAILRAPVDLLFNGGIGTYIKAESESDADVGDRANDPVRVNANQVRA 1140
			  	1141 KVIGEGGNLGVTALGRVEFDLSGGRINTDALDNSAGVDCSDHEVNIKILIDSLVSAGTVK 1200
			  	1201 ADERTQLLESMTDEVAQLVLADNEDQNDLMGTSRANAASLLPVHAMQIKYLVAERGVNRE 1260
			  	1261 LEALPSEKEIARRSEAGIGLTSPELATLMAHVKLGLKEEVLATELPDQDVFASRLPRYFP 1320
			  	1321 TALRERFTPEIRSHQLRREIVTTMLINDLVDTAGITYAFRIAEDVGVTPIDAVRTYVATD 1380
			  	1381 AIFGVGHIWRRIRAANLPIALSDRLTLDTRRLIDRAGRWLLNYRPQPLAVGAEINRFAAM 1440
			  	1441 VKALTPRMSEWLRGDDKAIVEKTAAEFASQGVPEDLAYRVSTGLYRYSLLDIIDIADIAD 1500
			  	1501 IDAAEVADTYFALMDRLGTDGLLTAVSQLPRHDRWHSLARLAIRDDIYGALRSLCFDVLA 1560
			  	1561 VGEPGESSEQKIAEWEHLSASRVARARRTLDDIRASGQKDLATLSVAARQIRRMTRTSGR 1620
			  	1621 GISG

Known structures in the PDB
No Known structures
1 163 325 487 649 811 973 1135 1297 1459 1621 Range: 81 to 1614  |  Coverage: 94% Bac_GDH Range: 702 to 255  |  Coverage: -27% 1 Range: 719 to 925  |  Coverage: 12% 1 Range: 1037 to 1294  |  Coverage: 15% 2
Number of amino acids : 1624
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Bac_GDHPF0508881-1614
Mtb Structural Proteome models
Model Number1
Model nameRv2476c
Template2BMA    APDBCREDO
Template coverage-17_446
Template Identity(%)15.0
Model coverage(%)34.1
Normalized DOPE score0.709

Structure Models from Chopin
Model Number1
Profilec.58.1.1
Click for model details
zscore5.3
Residue begin719
Residue end925
Model Number2
Profilec.23.5.4 - 3.40.50.360
Click for model details
zscore4.11
Residue begin1037
Residue end1294
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2476cGene nameConfidence Score
Rv3858cgltD0.949
Rv3858cgltD0.949
Rv3858cgltD0.949
Rv2220glnA10.948
Rv2220glnA10.948
Rv2439cproB0.939
Rv2439cproB0.939
Rv2222cglnA20.931
Rv2222cglnA20.931
Rv1187rocA0.93
Rv2391sirA0.919
Rv2211cgcvT0.919
Rv2391sirA0.919
Rv2211cgcvT0.919
Rv2860cglnA40.917
Rv2860cglnA40.917
Rv3859cgltB0.916
Rv3859cgltB0.916
Rv3859cgltB0.916
Rv3859cgltB0.916
Rv1538cansA0.913
Rv1653argJ0.91
Rv1240mdh0.908
Rv1240mdh0.908
Rv0252nirB0.904
Rv0252nirB0.904
Rv0252nirB0.904
Rv0252nirB0.904
Rv0252nirB0.904
Rv0253nirD0.901
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
alpha-ketoglutaratePubChem0.923146.098
glutamatePubChem0.922147.129
ammoniaPubChem0.917.0305