Rv3859c

Tuberculist information
Gene namegltB
Protein functionProbable ferredoxin-dependent glutamate synthase [NADPH] (large subunit) GltB (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate synthase) (glutamate synthase (NADH))(NADPH-GOGAT)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)4331.5
Molecular mass(da)165943
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 1527
	  		  	1    MTPKRVGLYNPAFEHDSCGVAMVVDMHGRRSRDIVDKAITALLNLEHRGAQGAEPRSGDG   60
			  	61   AGILIQVPDEFLREAVDFELPAPGSYATGIAFLPQSSKDAAAACAAVQKIAEAEGLQVLG  120
			  	121  WRSVPTDDSSLGALSRDAMPTFRQVFLAGASGMALERRCYVVRKRAEHELGTKGPGQDGP  180
			  	181  GRETVYFPSLSGQTLVYKGMLTTPQLKAFYLDLQDERLTSALGIVHSRFSTNTFPSWPLA  240
			  	241  HPFRRIAHNGEINTVTGNENWMRAREALIKTDIFGSAADVEKLFPICTPGASDTARFDEV  300
			  	301  LELLHLGGRSLAHAVLMMIPEAWERHESMDPARRAFYQYHASLMEPWDGPASMTFTDGTV  360
			  	361  VGAVLDRNGLRPSRIWVTDDGLVVMASEAGVLDLHPSTVVRRMRLQPGRMFLVDTAQGRI  420
			  	421  VSDEEIKADLAAEHPYQEWLDNGLVPLDELPEGKDVRMPHHRIVMRQLAFGYTYEELNLL  480
			  	481  VAPMARLGAEPIGSMGTDTPVAVLSQRPRMLYDYFHQLFAQVTNPPLDAIREEVVTSLQG  540
			  	541  TTGGERDLLNPDQNSCHQIVLPQPILRNHELAKLVSLDPNDKVNGRPHGLRSKVIRCLYR  600
			  	601  VSEGGAGLAAALEEVRGAAAAAIADGARIIILSDRESDEEMAPIPSLLAVAGVHHHLVRE  660
			  	661  RTRTQVGLVVESGDAREVHHMAALVGFGAAAINPYLVFESIEDMLDRGVIEGIDRTAALN  720
			  	721  NYIKAAGKGVLKVMSKMGISTLASYTGAQLFQAVGISEQVLDEYFTGLTCPTGGITLDDI  780
			  	781  AADVAARHRLAYLDRPDERAHRELEVGGEYQWRREGEYHLFNPETVFKLQHSTRTGQYKI  840
			  	841  FKEYTRLVDDQSERMASLRGLLKFRTGVRPPVPLDEVEPASEIVKRFSTGAMSYGSISAE  900
			  	901  AHETLAIAMNRLGARSNCGEGGEDVKRFDRDPNGDWRRSAIKQVASARFGVTSHYLTNCT  960
			  	961  DLQIKMAQGAKPGEGGQLPGHKVYPWVAEVRHSTPGVGLISPPPHHDIYSIEDLAQLIHD 1020
			  	1021 LKNANPSARVHVKLVSENGVGTVAAGVSKAHADVVLISGHDGGTGATPLTSMKHAGAPWE 1080
			  	1081 LGLAETQQTLLLNGLRDRIVVQVDGQLKTGRDVMIATLLGAEEFGFATAPLVVAGCIMMR 1140
			  	1141 VCHLDTCPVGVATQNPLLRERFTGKPEFVENFFMFIAEEVREYLAQLGFRTVNEAVGQAG 1200
			  	1201 ALDTTLARAHWKAHKLDLAPVLHEPESAFMNQDLYCSSRQDHGLDKALDQQLIVMSREAL 1260
			  	1261 DSGKPVRFSTTIGNVNRTVGTMLGHELTKAYGGQGLPDGTIDITFDGSAGNSFGAFVPKG 1320
			  	1321 ITLRVYGDANDYVGKGLSGGRIVVRPSDDAPQDYVAEDNIIGGNVILFGATSGEVYLRGV 1380
			  	1381 VGERFAVRNSGAHAVVEGVGDHGCEYMTGGRVVILGRTGRNFAAGMSGGVAYVYDPDGEL 1440
			  	1441 PANLNSEMVELETLDEDDADWLHGTIQVHVDATDSAVGQRILSDWSGQQRHFVKVMPRDY 1500
			  	1501 KRVLQAIALAERDGVDVDKAIMAAAHG

Known structures in the PDB
No Known structures
1 153 305 457 609 761 913 1065 1217 1369 1521 Range: 18 to 389  |  Coverage: 24% GATase_2 Range: 463 to 758  |  Coverage: 19% Glu_syn_central Range: 819 to 1190  |  Coverage: 24% Glu_synthase Range: 1268 to 1465  |  Coverage: 12% GXGXG Range: 18 to 489  |  Coverage: 30% 1 Range: 18 to 1510  |  Coverage: 97% 1 Range: 1240 to 1511  |  Coverage: 17% 2 Range: 1268 to 1465  |  Coverage: 12% 3 Range: 849 to 1207  |  Coverage: 23% 4 Range: 140 to 434  |  Coverage: 19% 5 Range: 140 to 663  |  Coverage: 34% 6
Number of amino acids : 1527
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
GATase_2PF0031018-389
Glu_syn_centralPF04898463-758
Glu_synthasePF01645819-1190
GXGXGPF014931268-1465
Mtb Structural Proteome models
Model Number1
Model nameRv3859c
Template1OFD    APDBCREDO
Template coverage1_1505
Template Identity(%)44.2
Model coverage(%)97.4
Normalized DOPE score-0.817

Structure Models from Chopin
Model Number1
Profileb.80.4.1, c.1.4.1, d.153.1.1
Click for model details
zscore188.67
Residue begin18
Residue end1510
Model Number2
Profileb.80.4.1
Click for model details
zscore60.09
Residue begin1240
Residue end1511
Model Number3
Profile2.160.20.60
Click for model details
zscore43.78
Residue begin1268
Residue end1465
Model Number4
Profilec.1.5.1 - 3.20.20.70
Click for model details
zscore10.88
Residue begin849
Residue end1207
Model Number5
Profiled.153.1.1
Click for model details
zscore10.71
Residue begin140
Residue end434
Model Number6
Profilec.61.1.1, d.153.1.1 - 3.40.50.2020, 3.60.20.10
Click for model details
zscore10.03
Residue begin140
Residue end663
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3859cGene nameConfidence Score
Rv3858cgltD0.999
Rv3858cgltD0.999
Rv3858cgltD0.999
Rv2220glnA10.991
Rv2220glnA10.991
Rv2222cglnA20.985
Rv2222cglnA20.985
Rv3432cgadB0.973
Rv0896gltA20.967
Rv1878glnA30.964
Rv2860cglnA40.964
Rv2860cglnA40.964
Rv1383carA0.962
Rv1383carA0.962
Rv0808purF0.95
Rv0808purF0.95
Rv3436cglmS0.948
Rv3436cglmS0.948
Rv1384carB0.948
Rv1384carB0.948
Rv1384carB0.948
Rv1384carB0.948
Rv0189cilvD0.932
Rv2476cgdh0.916
Rv1187rocA0.915
Rv2678chemE0.911
Rv2920camt0.905
Rv2988cleuC0.903
Rv1611trpC0.903
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
alpha-ketoglutaratePubChem0.987146.098
glutamatePubChem0.985147.129
polyglutaminePubChem0.936146.145
ammoniaPubChem0.79317.0305