Rv2988c

Tuberculist information
Gene nameleuC
Protein functionProbable 3-isopropylmalate dehydratase (large subunit) LeuC (isopropylmalate isomerase) (alpha-IPM isomerase) (IPMI)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)3344.65
Molecular mass(da)50185
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 473
	  		  	1    MALQTGEPRTLAEKIWDDHIVVSGGGCAPDLIYIDLHLVHEVTSPQAFDGLRLAGRRVRR   60
			  	61   PELTLATEDHNVPTVDIDQPIADPVSRTQVETLRRNCAEFGIRLHSMGDIEQGIVHVVGP  120
			  	121  QLGLTQPGMTIVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGR  180
			  	181  LPDGVSAKDIILALIAKIGTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAGMV  240
			  	241  APDETTYAFLRGRPHAPTGAQWDTALVYWQRLRTDVGAVFDTEVYLDAASLSPFVTWGTN  300
			  	301  PGQGVPLAAAVPDPQLMTDDAERQAAEKALAYMDLRPGTAMRDIAVDAVFVGSCTNGRIE  360
			  	361  DLRVVAEVLRGRKVADGVRMLIVPGSMRVRAQAEAEGLGEIFTDAGAQWRQAGCSMCLGM  420
			  	421  NPDQLASGERCAATSNRNFEGRQGAGGRTHLVSPAVAAATAVRGTLSSPADLN

Known structures in the PDB
No Known structures
1 48 95 142 189 236 283 330 377 424 471 Range: 10 to 464  |  Coverage: 95% Aconitase Range: 6 to 466  |  Coverage: 97% 1 Range: 1 to 473  |  Coverage: 99% 1 Range: 173 to 288  |  Coverage: 24% 2 Range: 1 to 172  |  Coverage: 36% 3
Number of amino acids : 473
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
AconitasePF0033010-464
Mtb Structural Proteome models
Model Number1
Model nameRv2988c
Template1C96    APDBCREDO
Template coverage33_478
Template Identity(%)27.8
Model coverage(%)97.3
Normalized DOPE score-0.343

Structure Models from Chopin
Model Number1
Profilec.83.1.1
Click for model details
zscore57.44
Residue begin1
Residue end473
Model Number2
Profile3.40.1060.10
Click for model details
zscore22.98
Residue begin173
Residue end288
Model Number3
Profile3.30.499.10
Click for model details
zscore19.67
Residue begin1
Residue end172
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2988cGene nameConfidence Score
Rv3710leuA0.999
Rv2987cleuD0.999
Rv3710leuA0.999
Rv2995cleuB0.999
Rv0189cilvD0.995
Rv3003cilvB10.992
Rv3003cilvB10.992
Rv3003cilvB10.992
Rv3001cilvC0.988
Rv3001cilvC0.988
Rv3455ctruA0.986
Rv1559ilvA0.979
Rv1559ilvA0.979
Rv2210cilvE0.978
Rv3002cilvN0.977
Rv3002cilvN0.977
Rv1652argC0.946
Rv1652argC0.946
Rv3708casd0.945
Rv3708casd0.945
Rv2540caroF0.933
Rv2332mez0.93
Rv2332mez0.93
Rv1605hisF0.923
Rv1653argJ0.91
Rv1654argB0.908
Rv3859cgltB0.903
Rv3859cgltB0.903
Rv3859cgltB0.903
Rv3859cgltB0.903
Rv1617pykA0.902
Rv1617pykA0.902
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
alpha-isopropylmalatePubChem0.987176.167
L-threo-3-methylmalatePubChem0.971148.114
citraconatePubChem0.969130.099
3-ISOPROPYLMALIC ACIDPubChem0.968176.167
mesaconatePubChem0.967130.099
2-isopropylmaleatePubChem0.951158.152
alpha-ketoisovaleratePubChem0.938116.115
citratePubChem0.921192.124
coenzyme APubChem0.909767.534
isocitratePubChem0.907192.124
D-isocitratePubChem0.907192.124
hydroxyl radicalsPubChem0.90617.0073
deuteriumPubChem0.9032.01588
H(+)PubChem0.9032.01588
C06032PubChem0.9148.114
acetyl-CoAPubChem0.9809.571
2-isopropylmalic acidPubChem0.9176.167
acetyl coenzyme-APubChem0.9809.571
Co-APubChem0.9767.534
protiumPubChem0.92.01576
beta-methyl-d-malatePubChem0.729146.098
lactatePubChem0.790.0779