Rv1559

Tuberculist information
Gene nameilvA
Protein functionProbable threonine dehydratase IlvA
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)1763.43
Molecular mass(da)45008.9
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 429
	  		  	1    VSAELSQSPSSSPLFSLSGADIDRAAKRIAPVVTPTPLQPSDRLSAITGATVYLKREDLQ   60
			  	61   TVRSYKLRGAYNLLVQLSDEELAAGVVCSSAGNHAQGFAYACRCLGVHGRVYVPAKTPKQ  120
			  	121  KRDRIRYHGGEFIDLIVGGSTYDLAAAAALEDVERTGATLVPPFDDLRTIAGQGTIAVEV  180
			  	181  LGQLEDEPDLVVVPVGGGGCIAGITTYLAERTTNTAVLGVEPAGAAAMMAALAAGEPVTL  240
			  	241  DHVDQFVDGAAVNRAGTLTYAALAAAGDMVSLTTVDEGAVCTAMLDLYQNEGIIAEPAGA  300
			  	301  LSVAGLLEADIEPGSTVVCLISGGNNDVSRYGEVLERSLVHLGLKHYFLVDFPQEPGALR  360
			  	361  RFLDDVLGPNDDITLFEYVKRNNRETGEALVGIELGSAADLDGLLARMRATDIHVEALEP  420
			  	421  GSPAYRYLL

Known structures in the PDB
No Known structures
1 43 85 127 169 211 253 295 337 379 421 Range: 29 to 323  |  Coverage: 68% PALP Range: 336 to 428  |  Coverage: 21% Thr_dehydrat_C Range: 3 to 429  |  Coverage: 99% 1 Range: 7 to 429  |  Coverage: 98% 1 Range: 29 to 323  |  Coverage: 68% 2 Range: 1 to 429  |  Coverage: 99% 3 Range: 336 to 428  |  Coverage: 21% 4
Number of amino acids : 429
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
PALPPF0029129-323
Thr_dehydrat_CPF00585336-428
Mtb Structural Proteome models
Model Number1
Model nameRv1559
Template1TDJ    APDBCREDO
Template coverage5_423
Template Identity(%)35.1
Model coverage(%)99.1
Normalized DOPE score0.295

Structure Models from Chopin
Model Number1
Profilec.79.1.1, d.58.18.2 - 3.40.1020.10, 3.40.50.1100
Click for model details
zscore52.05
Residue begin7
Residue end429
Model Number2
Profilec.79.1.1
Click for model details
zscore35.1
Residue begin29
Residue end323
Model Number3
Profilec.79.1.1
Click for model details
zscore22.05
Residue begin1
Residue end429
Model Number4
Profile3.40.1020.10
Click for model details
zscore14.96
Residue begin336
Residue end428
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1559Gene nameConfidence Score
Rv3003cilvB10.999
Rv3003cilvB10.999
Rv3003cilvB10.999
Rv0189cilvD0.997
Rv2995cleuB0.997
Rv3002cilvN0.996
Rv3002cilvN0.996
Rv3001cilvC0.994
Rv3001cilvC0.994
Rv2210cilvE0.984
Rv2987cleuD0.983
Rv2988cleuC0.979
Rv1820ilvG0.972
Rv1820ilvG0.972
Rv1820ilvG0.972
Rv1612trpB0.964
Rv3710leuA0.961
Rv3710leuA0.961
Rv0070cglyA20.957
Rv1093glyA10.957
Rv0069csdaA0.949
Rv0069csdaA0.949
Rv1613trpA0.948
Rv3042cserB20.943
Rv3042cserB20.943
Rv3470cilvB20.938
Rv3470cilvB20.938
Rv3470cilvB20.938
Rv1295thrC0.929
Rv2335cysE0.924
Rv2335cysE0.924
Rv1077cbs0.918
Rv1077cbs0.918
Rv2753cdapA0.909
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
alpha-ketobutyratePubChem0.978102.089
L-threoninePubChem0.974119.119
L-serinePubChem0.955105.093
ammoniaPubChem0.94317.0305
coenzyme APubChem0.941767.534
propionyl-CoAPubChem0.932823.597
CID-21PubChem0.918146.141
hydroxyl radicalsPubChem0.90517.0073
formatePubChem0.90345.0174
pyruvic acidPubChem0.988.0621
protiumPubChem0.92.01576
deuteriumPubChem0.92.01588
O-phosphohomoserinePubChem0.9199.099
O-PhosphorylhomoserinePubChem0.9199.099
phosphatePubChem0.996.9872
Co-APubChem0.9767.534
C06006PubChem0.9146.141
H(+)PubChem0.92.01588
n-propionyl-CoAPubChem0.9823.597
carbon dioxidePubChem0.944.0095
L-allo-threoninePubChem0.9119.119
pyridoxal phosphatePubChem0.888247.142
L-isoleucinePubChem0.701131.173