Rv0070c

Tuberculist information
Gene nameglyA2
Protein functionSerine hydroxymethyltransferase GlyA2 (serine methylase 2) (SHMT 2)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)77.619
Molecular mass(da)45525.7
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 425
	  		  	1    MNTLNDSLTAFDPDIAALIDGELRRQESGLEMIASENYAPLAVMQAQGSVLTNKYAEGYP   60
			  	61   GRRYYGGCEFVDGVEQLAIDRVKALFGAEYANVQPHSGATANAATMHALLNPGDTILGLS  120
			  	121  LAHGGHLTHGMRINFSGKLYHATAYEVSKEDYLVDMDAVAEAARTHRPKMIIAGWSAYPR  180
			  	181  QLDFARFRAIADEVDAVLMVDMAHFAGLVAAGVHPSPVPHAHVVTSTTHKTLGGPRGGII  240
			  	241  LCNDPAIAKKINSAVFPGQQGGPLEHVIAAKATAFKMAAQPEFAQRQQRCLDGARILAGR  300
			  	301  LTQPDVAERGIAVLTGGTDVHLVLVDLRDAELDGQQAEDRLAAVDITVNRNAVPFDPRPP  360
			  	361  MITSGLRIGTPALAARGFSHNDFRAVADLIAAALTATNDDQLGPLRAQVQRLAARYPLYP  420
			  	421  ELHRT

Known structures in the PDB
No Known structures
1 43 85 127 169 211 253 295 337 379 421 Range: 8 to 390  |  Coverage: 89% SHMT Range: 7 to 420  |  Coverage: 97% 1 Range: 1 to 425  |  Coverage: 99% 1
Number of amino acids : 425
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
SHMTPF004648-390
Mtb Structural Proteome models
Model Number1
Model nameRv0070c
Template1DFO    APDBCREDO
Template coverage7_417
Template Identity(%)54.3
Model coverage(%)97.2
Normalized DOPE score-0.714

Structure Models from Chopin
Model Number1
Profilec.67.1.4
Click for model details
zscore17.37
Residue begin1
Residue end425
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0070cGene nameConfidence Score
Rv2211cgcvT0.997
Rv2211cgcvT0.997
Rv3356cfolD0.997
Rv3356cfolD0.997
Rv1832gcvB0.995
Rv1832gcvB0.995
Rv0069csdaA0.994
Rv0069csdaA0.994
Rv3042cserB20.993
Rv3042cserB20.993
Rv0957purH0.988
Rv0957purH0.988
Rv2763cdfrA0.983
Rv2764cthyA0.983
Rv2964purU0.981
Rv2964purU0.981
Rv1612trpB0.98
Rv1406fmt0.979
Rv1406fmt0.979
Rv2124cmetH0.964
Rv2124cmetH0.964
Rv2124cmetH0.964
Rv2124cmetH0.964
Rv2124cmetH0.964
Rv0956purN0.96
Rv1559ilvA0.957
Rv1559ilvA0.957
Rv0389purT0.957
Rv3309cupp0.952
Rv1023eno0.951
Rv1023eno0.951
Rv1826gcvH0.948
Rv1613trpA0.938
Rv2335cysE0.934
Rv2335cysE0.934
Rv1077cbs0.93
Rv1077cbs0.93
Rv1133cmetE0.926
Rv1133cmetE0.926
Rv2614cthrS0.925
Rv2614cthrS0.925
Rv2614cthrS0.925
Rv1437pgk0.923
Rv1649pheS0.921
Rv1649pheS0.921
Rv2448cvalS0.92
Rv2448cvalS0.92
Rv2448cvalS0.92
Rv2992cgltS0.912
Rv0505cserB10.907
Rv2580chisS0.904
Rv2580chisS0.904
Rv3336ctrpS0.902
Rv0041leuS0.901
Rv0041leuS0.901
Rv0041leuS0.901
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
tetrahydrofolatePubChem0.982445.429
L-serinePubChem0.972105.093
polyglycinePubChem0.96375.0666
glyoxylatePubChem0.95474.0355
5,10-methylenetetrahydrofolatePubChem0.95457.44
5-methyltetrahydrofolatePubChem0.947459.456
pyridoxal phosphatePubChem0.947247.142
5,10-methenyltetrahydrofolatePubChem0.944456.432
H4FPubChem0.943445.429
methenyltetrahydrofolatePubChem0.934456.432
thymidylatePubChem0.929322.208
N5,N10-methylenetetrahydrofolatePubChem0.929457.44
phosphatePubChem0.92796.9872
homocysteinePubChem0.925135.185
methyltetrahydrofolatePubChem0.925459.456
L-methioninePubChem0.92149.211
dUMPPubChem0.92308.182
L-homocysteinePubChem0.903135.185
dihydrofolatePubChem0.902443.413
DL-serinePubChem0.9105.093
reduced nicotinamide adenine dinucleotidePubChem0.9665.441
protiumPubChem0.92.01576
dihydronicotinamide formycin dinucleotidePubChem0.9665.441
NADP(H)PubChem0.9745.421
hydroxypyruvatePubChem0.9104.061
NAD+PubChem0.9663.425
H(+)PubChem0.92.01588
NADPPubChem0.9744.413
O-phosphoserinePubChem0.9185.072
hydroxyl radicalsPubChem0.917.0073
deuteriumPubChem0.92.01588
5-formyltetrahydrofolatePubChem0.74473.439
L-alaninePubChem0.71189.0932
D-alaninePubChem0.7189.0932
folatePubChem0.707441.397
leucovorinPubChem0.704473.439