Rv2964

Tuberculist information
Gene namepurU
Protein functionProbable formyltetrahydrofolate deformylase PurU (formyl-FH(4) hydrolase)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)3316.53
Molecular mass(da)34006
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 310
	  		  	1    MGKGSMTAHATPNEPDYPPPPGGPPPPADIGRLLLRCHDRPGIIAAVSTFLARAGANIIS   60
			  	61   LDQHSTAPEGGTFLQRAIFHLPGLTAAVDELQRDFGSTVADKFGIDYRFAEAAKPKRVAI  120
			  	121  MASTEDHCLLDLLWRNRRGELEMSVVMVIANHPDLAAHVRPFGVPFIHIPATRDTRTEAE  180
			  	181  QRQLQLLSGNVDLVVLARYMQILSPGFLEAIGCPLINIHHSFLPAFTGAAPYQRARERGV  240
			  	241  KLIGATAHYVTEVLDEGPIIEQDVVRVDHTHTVDDLVRVGADVERAVLSRAVLWHCQDRV  300
			  	301  IVHHNQTIVF

Known structures in the PDB
No Known structures
1 32 63 94 125 156 187 218 249 280 311 Range: 31 to 96  |  Coverage: 20% ACT Range: 116 to 292  |  Coverage: 56% Formyl_trans_N Range: 30 to 106  |  Coverage: 24% 1 Range: 117 to 305  |  Coverage: 60% 2 Range: 116 to 292  |  Coverage: 56% 1 Range: 31 to 96  |  Coverage: 20% 2 Range: 38 to 310  |  Coverage: 87% 3 Range: 27 to 299  |  Coverage: 87% 4
Number of amino acids : 310
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
ACTPF0184231-96
Formyl_trans_NPF00551116-292
Mtb Structural Proteome models
Model Number1
Model nameRv2964.1
Template1ZPV    APDBCREDO
Template coverage2_77
Template Identity(%)26.3
Model coverage(%)24.5
Normalized DOPE score-0.862

Model Number2
Model nameRv2964
Template1MEO    APDBCREDO
Template coverage2_194
Template Identity(%)30.2
Model coverage(%)60.6
Normalized DOPE score-0.763

Structure Models from Chopin
Model Number1
Profilec.65.1.1 - 3.40.50.170
Click for model details
zscore36.07
Residue begin116
Residue end292
Model Number2
Profiled.58.18.7 - 3.30.70.260
Click for model details
zscore12.12
Residue begin31
Residue end96
Model Number3
Profilec.65.1.1
Click for model details
zscore11.49
Residue begin38
Residue end310
Model Number4
Profilec.23.1.7, d.58.18.12 - 3.30.70.260, 3.40.50.10550
Click for model details
zscore4.27
Residue begin27
Residue end299
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2964Gene nameConfidence Score
Rv3356cfolD0.996
Rv3356cfolD0.996
Rv2211cgcvT0.984
Rv2211cgcvT0.984
Rv0070cglyA20.981
Rv1093glyA10.981
Rv0389purT0.968
Rv2124cmetH0.959
Rv2124cmetH0.959
Rv2124cmetH0.959
Rv2124cmetH0.959
Rv2124cmetH0.959
Rv2763cdfrA0.957
Rv2754cthyX0.942
Rv2900cfdhF0.935
Rv2900cfdhF0.935
Rv0956purN0.927
Rv3709cask0.901
Rv3709cask0.901
Rv3709cask0.901
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
tetrahydrofolatePubChem0.968445.429
formatePubChem0.95745.0174
10-formyltetrahydrofolatePubChem0.942473.439
phosphatePubChem0.996.9872
methenyltetrahydrofolatePubChem0.9456.432
adenosine diphosphatePubChem0.9427.201
H4FPubChem0.9445.429
10-formyltetrahydropteroylglutamic acidPubChem0.9473.439
hydroxyl radicalsPubChem0.917.0073
H(+)PubChem0.92.01588
5,10-methenyltetrahydrofolatePubChem0.9456.432
adenosine triphosphatePubChem0.9507.181
protiumPubChem0.92.01576
deuteriumPubChem0.92.01588
selenomethioninePubChem0.773196.106
SeMetPubChem0.773196.106
ethylene glycol; hydronPubChem0.74263.0758
polyethylene glycolPubChem0.74262.0678