Rv0389

Tuberculist information
Gene namepurT
Protein functionProbable phosphoribosylglycinamide formyltransferase 2 PurT (GART 2) (gar transformylase 2) (5'-phosphoribosylglycinamide transformylase 2) (formate-dependent gar transformylase)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)468.335
Molecular mass(da)43645.7
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 419
	  		  	1    VIDGWTEEQHEPTVRHERPAAPQDVRRVMLLGSAEPSRELAIALQGLGAEVIAVDGYVGA   60
			  	61   PAHRIADQSVVVTMTDAEELTAVIRRLQPDFLVTVTAAVSVDALDAVEQADGECTELVPN  120
			  	121  ARAVRCTADREGLRRLAADQLGLPTAPFWFVGSLGELQAVAVHAGFPLLVSPVAGVAGQG  180
			  	181  SSVVAGPNEVEPAWQRAAGHQVQPQTGGVSPRVCAESVVEIEFLVTMIVVCSQGPNGPLI  240
			  	241  EFCAPIGHRDADAGELESWQPQKLSTAALDAAKSIAARIVKALGGRGVFGVELMINGDEV  300
			  	301  YFADVTVCPAGSAWVTVRSQRLSVFELQARAILGLAVDTLMISPGAARVINPDHTAGRAA  360
			  	361  VGAAPPADALTGALGVPESDVVIFGRGLGVALATAPEVAIARERAREVASRLNVPDSRE

Known structures in the PDB
No Known structures
1 42 83 124 165 206 247 288 329 370 411 Range: 138 to 320  |  Coverage: 43% ATP-grasp Range: 20 to 416  |  Coverage: 94% 1 Range: 75 to 410  |  Coverage: 79% 1 Range: 15 to 132  |  Coverage: 27% 2
Number of amino acids : 419
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
ATP-graspPF02222138-320
Mtb Structural Proteome models
Model Number1
Model nameRv0389
Template1KJQ    APDBCREDO
Template coverage7_392
Template Identity(%)40.2
Model coverage(%)94.5
Normalized DOPE score-0.605

Structure Models from Chopin
Model Number1
Profiled.142.1.2
Click for model details
zscore14.07
Residue begin75
Residue end410
Model Number2
Profilec.30.1.1
Click for model details
zscore10.77
Residue begin15
Residue end132
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0389Gene nameConfidence Score
Rv0956purN0.997
Rv0957purH0.992
Rv0957purH0.992
Rv3276cpurK0.985
Rv0772purD0.981
Rv0772purD0.981
Rv0772purD0.981
Rv0788purQ0.976
Rv2964purU0.968
Rv2964purU0.968
Rv3356cfolD0.963
Rv3356cfolD0.963
Rv3275cpurE0.961
Rv0070cglyA20.957
Rv0809purM0.956
Rv0809purM0.956
Rv1093glyA10.955
Rv0803purL0.954
Rv0803purL0.954
Rv2763cdfrA0.949
Rv2754cthyX0.943
Rv0808purF0.943
Rv0808purF0.943
Rv1406fmt0.91
Rv1406fmt0.91
Rv2211cgcvT0.908
Rv2211cgcvT0.908
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
glycinamide ribonucleotidePubChem0.983286.176
adenosine diphosphatePubChem0.98427.201
adenosine triphosphatePubChem0.965507.181
formatePubChem0.96145.0174
10-formyltetrahydrofolatePubChem0.96473.439
tetrahydrofolatePubChem0.953445.429
FGARPubChem0.947314.186
formylglycinamide ribonucleotidePubChem0.946314.186
5'-phosphoribosyl-N-formylglycinamidePubChem0.943314.186
phosphatePubChem0.90796.9872
5'-phosphoribosylformylglycinamidinePubChem0.9313.202
protiumPubChem0.92.01576
glutamatePubChem0.9147.129
glutaminPubChem0.9146.145
phosphoribosylaminePubChem0.9229.125
polyglycinePubChem0.975.0666
5,10-methenyltetrahydrofolatePubChem0.9456.432
hydroxyl radicalsPubChem0.917.0073
FGAMPubChem0.9312.194
NSC333308PubChem0.9286.176
methenyltetrahydrofolatePubChem0.9456.432
polyglutaminePubChem0.9146.145
H(+)PubChem0.92.01588
deuteriumPubChem0.92.01588
5-phosphoribosylaminePubChem0.9229.125
AMPPNPPubChem0.752506.196