Rv0772

Tuberculist information
Gene namepurD
Protein functionProbable phosphoribosylamine--glycine ligase PurD (GARS) (glycinamide ribonucleotide synthetase) (phosphoribosylglycinamide synthetase) (5'-phosphoribosylglycinamide synthetase)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)864.586
Molecular mass(da)43476.6
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 422
	  		  	1    VRVLVIGSGAREHALLLALGKDPQVSGLIVAPGNAGTARIAEQHDVDITSAEAVVALARE   60
			  	61   VGADMVVIGPEVPLVLGVADAVRAAGIVCFGPGKDAARIEGSKAFAKDVMAAAGVRTANS  120
			  	121  EIVDSPAHLDAALDRFGPPAGDPAWVVKDDRLAAGKGVVVTADRDVARAHGAALLEAGHP  180
			  	181  VLLESYLDGPEVSLFCVVDRTVVVPLLPAQDFKRVGEDDTGLNTGGMGAYAPLPWLPDNI  240
			  	241  YREVVSRIVEPVAAELVRRGSSFCGLLYVGLAITARGPAVVEFNCRFGDPETQAVLALLE  300
			  	301  SPLGQLLHAAATGKLADFGELRWRDGVAVTVVLAAENYPGRPRVGDVVVGSEAEGVLHAG  360
			  	361  TTRRDDGAIVSSGGRVLSVVGTGADLSAARAHAYEILSSIRLPGGHFRSDIGLRAAEGKI  420
			  	421  SV

Known structures in the PDB
No Known structures
1 43 85 127 169 211 253 295 337 379 421 Range: 1 to 100  |  Coverage: 23% GARS_N Range: 101 to 292  |  Coverage: 45% GARS_A Range: 327 to 416  |  Coverage: 21% GARS_C Range: 1 to 418  |  Coverage: 98% 1 Range: 49 to 398  |  Coverage: 82% 1 Range: 327 to 421  |  Coverage: 22% 2 Range: 1 to 105  |  Coverage: 24% 3 Range: 140 to 331  |  Coverage: 45% 4
Number of amino acids : 422
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
GARS_NPF028441-100
GARS_APF01071101-292
GARS_CPF02843327-416
Mtb Structural Proteome models
Model Number1
Model nameRv0772
Template1GSO    APDBCREDO
Template coverage1_426
Template Identity(%)39.8
Model coverage(%)98.8
Normalized DOPE score-0.456

Structure Models from Chopin
Model Number1
Profiled.142.1.2
Click for model details
zscore20.53
Residue begin49
Residue end398
Model Number2
Profile3.90.600.10
Click for model details
zscore20.13
Residue begin327
Residue end421
Model Number3
Profilec.30.1.1
Click for model details
zscore18.07
Residue begin1
Residue end105
Model Number4
Profile3.30.470.20
Click for model details
zscore12.78
Residue begin140
Residue end331
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0772Gene nameConfidence Score
Rv0956purN0.999
Rv3275cpurE0.999
Rv0808purF0.999
Rv0808purF0.999
Rv0809purM0.998
Rv0809purM0.998
Rv0788purQ0.998
Rv0957purH0.998
Rv0957purH0.998
Rv0780purC0.994
Rv0777purB0.992
Rv0777purB0.992
Rv0382cpyrE0.99
Rv1380pyrB0.981
Rv1380pyrB0.981
Rv0389purT0.981
Rv3396cguaA0.978
Rv3396cguaA0.978
Rv3396cguaA0.978
Rv0803purL0.973
Rv0803purL0.973
Rv0357cpurA0.972
Rv2139pyrD0.969
Rv3356cfolD0.955
Rv3356cfolD0.955
Rv1379pyrR0.946
Rv3276cpurK0.936
Rv1605hisF0.92
Rv1383carA0.918
Rv1383carA0.918
Rv1656argF0.915
Rv1656argF0.915
Rv1599hisD0.905
Rv0787ARv0787A0.902
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
phosphatePubChem0.98596.9872
phosphoribosylaminePubChem0.981229.125
glycinamide ribonucleotidePubChem0.981286.176
adenosine triphosphatePubChem0.972507.181
polyglycinePubChem0.96875.0666
phosphoribosylpyrophosphatePubChem0.96390.07
5-aminoimidazole ribonucleotidePubChem0.957295.186
formylglycinamide ribonucleotidePubChem0.947314.186
adenosine diphosphatePubChem0.932427.201
10-formyltetrahydrofolatePubChem0.924473.439
FGARPubChem0.918314.186
5'-phosphoribosylformylglycinamidinePubChem0.917313.202
tetrahydrofolatePubChem0.916445.429
5'-phosphoribosyl-N-formylglycinamidePubChem0.913314.186
glycineamide ribonucleotidePubChem0.913286.176
H4FPubChem0.905445.429
formatePubChem0.90145.0174
polyglutaminePubChem0.9146.145
NSC333308PubChem0.9286.176
10-formyltetrahydropteroylglutamic acidPubChem0.9473.439
H(+)PubChem0.92.01588
glutamatePubChem0.9147.129
CHEBI:28843PubChem0.9295.186
5-phosphoribosylaminePubChem0.9229.125
deuteriumPubChem0.92.01588
CHEBI:18413PubChem0.9313.202
protiumPubChem0.92.01576
hydroxyl radicalsPubChem0.917.0073
glutaminPubChem0.9146.145
Chebi:18272PubChem0.9314.186
pyrophosphatePubChem0.9177.975
SeMetPubChem0.879196.106
selenomethioninePubChem0.861196.106
sulfatePubChem0.896.0626
hydron diphosphatePubChem0.799391.981
hydron sulfatePubChem0.79196.157
ethylene glycol; hydronPubChem0.78463.0758
polyethylene glycolPubChem0.78462.0678
glycerolPubChem0.73792.0938
adenosine monophosphatePubChem0.718347.221
Na(+)PubChem0.71722.9898