Rv0382c

Tuberculist information
Gene namepyrE
Protein functionProbable orotate phosphoribosyltransferase PyrE (OPRT) (oprtase)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)457.841
Molecular mass(da)18860.4
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 179
	  		  	1    VAGPDRAELAELVRRLSVVHGRVTLSSGREADYYVDLRRATLHHRASALIGRLMRELTAD   60
			  	61   WDYSVVGGLTLGADPVATAIMHAPGRPIDAFVVRKSAKAHGMQRLIEGSEVTGQRVLVVE  120
			  	121  DTSTTGNSALTAVHAVQDVGGEVVGVATVVDRATGAAEAIEAEGLRYRSVLGLADLGLD

Known structures in the PDB
No Known structures
1 18 35 52 69 86 103 120 137 154 171 Range: 39 to 150  |  Coverage: 62% Pribosyltran Range: 1 to 178  |  Coverage: 98% 1 Range: 1 to 179  |  Coverage: 99% 1
Number of amino acids : 179
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
PribosyltranPF0015639-150
Mtb Structural Proteome models
Model Number1
Model nameRv0382c
Template1LH0    APDBCREDO
Template coverage1001_1189
Template Identity(%)26.4
Model coverage(%)98.9
Normalized DOPE score0.248

Structure Models from Chopin
Model Number1
Profilec.61.1.1 - 3.40.50.2020
Click for model details
zscore13.42
Residue begin1
Residue end179
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0382cGene nameConfidence Score
Rv1385pyrF0.999
Rv2139pyrD0.999
Rv2883cpyrH0.993
Rv1380pyrB0.992
Rv1380pyrB0.992
Rv0772purD0.99
Rv0772purD0.99
Rv0772purD0.99
Rv1017cprsA0.983
Rv1017cprsA0.983
Rv1379pyrR0.982
Rv1383carA0.974
Rv1383carA0.974
Rv1699pyrG0.97
Rv1699pyrG0.97
Rv1656argF0.956
Rv1656argF0.956
Rv1381pyrC0.953
Rv1384carB0.945
Rv1384carB0.945
Rv1384carB0.945
Rv1384carB0.945
Rv0957purH0.94
Rv0957purH0.94
Rv3309cupp0.933
Rv1605hisF0.924
Rv1606hisI0.92
Rv0808purF0.904
Rv0808purF0.904
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
phosphoribosylpyrophosphatePubChem0.983390.07
orotic acidPubChem0.981156.096
orotidine 5'-monophosphatePubChem0.977368.191
orotidine 5-phosphatePubChem0.96368.191
polyuridylic acidPubChem0.945324.181
pyrophosphatePubChem0.944177.975
uridine diphosphatePubChem0.908404.161
protiumPubChem0.92.01576
adenosine triphosphatePubChem0.9507.181
deuteriumPubChem0.92.01588
adenosine diphosphatePubChem0.9427.201
carbon dioxidePubChem0.944.0095
H(+)PubChem0.92.01588
uracilPubChem0.762112.087