Rv1385

Tuberculist information
Gene namepyrF
Protein functionProbable orotidine 5'-phosphate decarboxylase PyrF (OMP decarboxylase) (ompdecase)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)1560.44
Molecular mass(da)27345.2
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 274
	  		  	1    VTGFGLRLAEAKARRGPLCLGIDPHPELLRGWDLATTADGLAAFCDICVRAFADFAVVKP   60
			  	61   QVAFFESYGAAGFAVLERTIAELRAADVLVLADAKRGDIGATMSAYATAWVGDSPLAADA  120
			  	121  VTASPYLGFGSLRPLLEVAAAHGRGVFVLAATSNPEGAAVQNAAADGRSVAQLVVDQVGA  180
			  	181  ANEAAGPGPGSIGVVVGATAPQAPDLSAFTGPVLVPGVGVQGGRPEALGGLGGAASSQLL  240
			  	241  PAVAREVLRAGPGVPELRAAGERMRDAVAYLAAV

Known structures in the PDB
No Known structures
1 28 55 82 109 136 163 190 217 244 271 Range: 16 to 260  |  Coverage: 89% OMPdecase Range: 2 to 271  |  Coverage: 98% 1 Range: 1 to 272  |  Coverage: 98% 1
Number of amino acids : 274
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
OMPdecasePF0021516-260
Mtb Structural Proteome models
Model Number1
Model nameRv1385
Template2F84    APDBCREDO
Template coverage1_316
Template Identity(%)22.6
Model coverage(%)97.8
Normalized DOPE score0.205

Structure Models from Chopin
Model Number1
Profilec.1.2.3 - 3.20.20.70
Click for model details
zscore9.71
Residue begin1
Residue end272
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1385Gene nameConfidence Score
Rv0382cpyrE0.999
Rv1379pyrR0.999
Rv1380pyrB0.998
Rv1380pyrB0.998
Rv2139pyrD0.991
Rv3309cupp0.99
Rv2883cpyrH0.981
Rv1383carA0.979
Rv1383carA0.979
Rv1381pyrC0.969
Rv1384carB0.967
Rv1384carB0.967
Rv1384carB0.967
Rv1384carB0.967
Rv1382Rv13820.921
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
orotidine 5'-monophosphatePubChem0.935368.191
polyuridylic acidPubChem0.927324.181
protiumPubChem0.92.01576
uridine diphosphatePubChem0.9404.161
adenosine triphosphatePubChem0.9507.181
deuteriumPubChem0.92.01588
orotidine 5-phosphatePubChem0.9368.191
phosphoribosylpyrophosphatePubChem0.9390.07
adenosine diphosphatePubChem0.9427.201
carbon dioxidePubChem0.944.0095
orotic acidPubChem0.9156.096
H(+)PubChem0.92.01588
pyrophosphatePubChem0.9177.975
uracilPubChem0.748112.087