Rv1380

Tuberculist information
Gene namepyrB
Protein functionProbable aspartate carbamoyltransferase PyrB (ATCase) (aspartate transcarbamylase)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)1553.23
Molecular mass(da)33818.6
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 319
	  		  	1    MTPRHLLTAADLSRDDATAILDDADRFAQALVGRDIKKLPTLRGRTVVTMFYENSTRTRV   60
			  	61   SFEVAGKWMSADVINVSAAGSSVGKGESLRDTALTLRAAGADALIIRHPASGAAHLLAQW  120
			  	121  TGAHNDGPAVINAGDGTHEHPTQALLDALTIRQRLGGIEGRRIVIVGDILHSRVARSNVM  180
			  	181  LLDTLGAEVVLVAPPTLLPVGVTGWPATVSHDFDAELPAADAVLMLRVQAERMNGGFFPS  240
			  	241  VREYSVRYGLTERRQAMLPGHAVVLHPGPMVRGMEITSSVADSSQSAVLQQVSNGVQVRM  300
			  	301  AVLFHVLVGAQDAGKEGAA

Known structures in the PDB
No Known structures
1 32 63 94 125 156 187 218 249 280 311 Range: 4 to 154  |  Coverage: 47% OTCace_N Range: 159 to 306  |  Coverage: 46% OTCace Range: 4 to 307  |  Coverage: 94% 1 Range: 159 to 306  |  Coverage: 46% 1 Range: 4 to 154  |  Coverage: 47% 2 Range: 1 to 319  |  Coverage: 99% 3
Number of amino acids : 319
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
OTCace_NPF027294-154
OTCacePF00185159-306
Mtb Structural Proteome models
Model Number1
Model nameRv1380
Template1ML4    APDBCREDO
Template coverage6_305
Template Identity(%)36.0
Model coverage(%)95.0
Normalized DOPE score-0.671

Structure Models from Chopin
Model Number1
Profilec.78.1.1
Click for model details
zscore21.73
Residue begin159
Residue end306
Model Number2
Profile3.40.50.1370
Click for model details
zscore14.62
Residue begin4
Residue end154
Model Number3
Profile3.40.50.1370
Click for model details
zscore12.65
Residue begin1
Residue end319
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1380Gene nameConfidence Score
Rv1384carB0.999
Rv1384carB0.999
Rv1379pyrR0.999
Rv1384carB0.999
Rv1381pyrC0.999
Rv1383carA0.999
Rv1383carA0.999
Rv1384carB0.999
Rv1385pyrF0.998
Rv2139pyrD0.996
Rv0382cpyrE0.992
Rv0357cpurA0.99
Rv1658argG0.987
Rv0772purD0.981
Rv0772purD0.981
Rv0772purD0.981
Rv1653argJ0.962
Rv3275cpurE0.96
Rv3709cask0.958
Rv3709cask0.958
Rv3709cask0.958
Rv1656argF0.957
Rv1656argF0.957
Rv3309cupp0.956
Rv1699pyrG0.954
Rv1699pyrG0.954
Rv1017cprsA0.942
Rv1017cprsA0.942
Rv3601cpanD0.941
Rv2201asnB0.933
Rv2201asnB0.933
Rv2448cvalS0.932
Rv2448cvalS0.932
Rv2448cvalS0.932
Rv2121chisG0.93
Rv2121chisG0.93
Rv0957purH0.929
Rv0957purH0.929
Rv1595nadB0.928
Rv1595nadB0.928
Rv2439cproB0.926
Rv2439cproB0.926
Rv1538cansA0.922
Rv0973caccA20.917
Rv0973caccA20.917
Rv0973caccA20.917
Rv0973caccA20.917
Rv2445cndkA0.911
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
carbamoyl phosphatePubChem0.993141.02
aspartatePubChem0.989133.103
carbamyl aspartatePubChem0.988176.127
phosphatePubChem0.97396.9872
carbamyl-DL-aspartic acidPubChem0.972176.127
adenosine triphosphatePubChem0.962507.181
dihydroorotic acidPubChem0.936158.112
dihydroorotatePubChem0.933158.112
glutamatePubChem0.931147.129
ornithinePubChem0.929132.161
N-(phosphonacetyl)-L-aspartatePubChem0.921255.119
polyglutaminePubChem0.92146.145
bicarbonatePubChem0.90162.0248
hydroxyl radicalsPubChem0.90117.0073
deuteriumPubChem0.92.01588
protiumPubChem0.92.01576
glutaminPubChem0.9146.145
adenosine diphosphatePubChem0.9427.201
potassium aspartatePubChem0.9133.103
H(+)PubChem0.92.01588
cytidine triphosphatePubChem0.868483.156
ara-CTPPubChem0.866483.156
zincPubChem0.8465.409
fumaratePubChem0.81116.072
polyuridylic acidPubChem0.809324.181
citratePubChem0.804192.124
succinatePubChem0.797118.088
maleatePubChem0.773116.072
L-alanosinePubChem0.763149.105
uracilPubChem0.747112.087
sulfatePubChem0.73796.0626
hydron sulfatePubChem0.737196.157