Rv2201

Tuberculist information
Gene nameasnB
Protein functionProbable asparagine synthetase AsnB
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)2465
Molecular mass(da)72117.5
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 652
	  		  	1    VCGLLAFVAAPAGAAGPEGADAASAIARASHLMRHRGPDESGTWHAVDGASGGVVFGFNR   60
			  	61   LSIIDIAHSHQPLRWGPPEAPDRYVLVFNGEIYNYLELRDELRTQHGAVFATDGDGEAIL  120
			  	121  AGYHHWGTEVLQRLRGMFAFALWDTVTRELFCARDPFGIKPLFIATGAGGTAVASEKKCL  180
			  	181  LDLVELVGFDTEIDHRALQHYTVLQYVPEPETLHRGVRRLESGCFARIRADQLAPVITRY  240
			  	241  FVPRFAASPITNDNDQARYDEITAVLEDSVAKHMRADVTVGAFLSGGIDSTAIAALAIRH  300
			  	301  NPRLITFTTGFEREGFSEIDVAVASAEAIGARHIAKVVSADEFVAALPEIVWYLDEPVAD  360
			  	361  PALVPLFFVAREARKHVKVVLSGEGADELFGGYTIYREPLSLRPFDYLPKPLRRSMGKVS  420
			  	421  KPLPEGMRGKSLLHRGSLTLEERYYGNARSFSGAQLREVLPGFRPDWTHTDVTAPVYAES  480
			  	481  AGWDPVARMQHIDLFTWLRGDILVKADKITMANSLELRVPFLDPEVFAVASRLPAGAKIT  540
			  	541  RTTTKYALRRALEPIVPAHVLHRPKLGFPVPIRHWLRAGELLEWAYATVGSSQAGHLVDI  600
			  	601  AAVYRMLDEHRCGSSDHSRRLWTMLIFMLWHAIFVEHSVVPQISEPQYPVQL

Known structures in the PDB
No Known structures
1 66 131 196 261 326 391 456 521 586 651 Range: 58 to 182  |  Coverage: 19% GATase_7 Range: 261 to 565  |  Coverage: 46% Asn_synthase Range: 22 to 621  |  Coverage: 91% 1 Range: 1 to 652  |  Coverage: 99% 1 Range: 58 to 182  |  Coverage: 19% 2 Range: 2 to 249  |  Coverage: 37% 3 Range: 239 to 558  |  Coverage: 48% 4
Number of amino acids : 652
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
GATase_7PF1353758-182
Asn_synthasePF00733261-565
Mtb Structural Proteome models
Model Number1
Model nameRv2201
Template1JGT    APDBCREDO
Template coverage6_495
Template Identity(%)22.9
Model coverage(%)91.9
Normalized DOPE score0.946

Structure Models from Chopin
Model Number1
Profilec.26.2.1, d.153.1.1 - 3.40.50.620, 3.60.20.10
Click for model details
zscore63.43
Residue begin1
Residue end652
Model Number2
Profiled.153.1.1
Click for model details
zscore25.62
Residue begin58
Residue end182
Model Number3
Profiled.153.1.1
Click for model details
zscore25.02
Residue begin2
Residue end249
Model Number4
Profilec.26.2.1 - 3.40.50.620
Click for model details
zscore10.98
Residue begin239
Residue end558
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2201Gene nameConfidence Score
Rv2220glnA10.959
Rv2220glnA10.959
Rv1658argG0.955
Rv2222cglnA20.939
Rv2222cglnA20.939
Rv1380pyrB0.933
Rv1380pyrB0.933
Rv0808purF0.923
Rv0808purF0.923
Rv3709cask0.913
Rv3709cask0.913
Rv3709cask0.913
Rv2860cglnA40.913
Rv0357cpurA0.913
Rv2860cglnA40.913
Rv3009cgatB0.908
Rv3009cgatB0.908
Rv1595nadB0.901
Rv1595nadB0.901
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
glutamatePubChem0.938147.129
ammoniaPubChem0.92817.0305
polyglutaminePubChem0.927146.145
aspartatePubChem0.92133.103
adenosine monophosphatePubChem0.916347.221
L-asparaginePubChem0.914132.118
pyrophosphatePubChem0.912177.975
hydroxyl radicalsPubChem0.917.0073
adenosine triphosphatePubChem0.9507.181
potassium aspartatePubChem0.9133.103
H(+)PubChem0.92.01588
deuteriumPubChem0.92.01588
ASPARAGINEPubChem0.9132.118
glutaminPubChem0.9146.145
protiumPubChem0.92.01576