Rv2220

Tuberculist information
Gene nameglnA1
Protein functionGlutamine synthetase GlnA1 (glutamine synthase) (GS-I)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)2487.61
Molecular mass(da)53537.9
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 478
	  		  	1    VTEKTPDDVFKLAKDEKVEYVDVRFCDLPGIMQHFTIPASAFDKSVFDDGLAFDGSSIRG   60
			  	61   FQSIHESDMLLLPDPETARIDPFRAAKTLNINFFVHDPFTLEPYSRDPRNIARKAENYLI  120
			  	121  STGIADTAYFGAEAEFYIFDSVSFDSRANGSFYEVDAISGWWNTGAATEADGSPNRGYKV  180
			  	181  RHKGGYFPVAPNDQYVDLRDKMLTNLINSGFILEKGHHEVGSGGQAEINYQFNSLLHAAD  240
			  	241  DMQLYKYIIKNTAWQNGKTVTFMPKPLFGDNGSGMHCHQSLWKDGAPLMYDETGYAGLSD  300
			  	301  TARHYIGGLLHHAPSLLAFTNPTVNSYKRLVPGYEAPINLVYSQRNRSACVRIPITGSNP  360
			  	361  KAKRLEFRSPDSSGNPYLAFSAMLMAGLDGIKNKIEPQAPVDKDLYELPPEEAASIPQTP  420
			  	421  TQLSDVIDRLEADHEYLTEGGVFTNDLIETWISFKRENEIEPVNIRPHPYEFALYYDV

Known structures in the PDB
PDB ID1HTO
Total residue count11448
Number of chains24
MethodX-RAY
Resolution2.4
PDB ID1HTQ
Total residue count11448
Number of chains24
MethodX-RAY
Resolution2.4
PDB ID2BVC
Total residue count2916
Number of chains6
MethodX-RAY
Resolution2.1
PDB ID2WGS
Total residue count5832
Number of chains12
MethodX-RAY
Resolution2.55
PDB ID2WHI
Total residue count2916
Number of chains6
MethodX-RAY
Resolution2.2
PDB ID3ZXR
Total residue count2916
Number of chains6
MethodX-RAY
Resolution2.15
PDB ID3ZXV
Total residue count2916
Number of chains6
MethodX-RAY
Resolution2.26
PDB ID4ACF
Total residue count2916
Number of chains6
MethodX-RAY
Resolution2
1 48 95 142 189 236 283 330 377 424 471 Range: 17 to 98  |  Coverage: 16% Gln-synt_N Range: 105 to 387  |  Coverage: 58% Gln-synt_C Range: 4 to 478  |  Coverage: 99% 1 Range: 4 to 478  |  Coverage: 99% 2 Range: 4 to 478  |  Coverage: 99% 1 Range: 105 to 478  |  Coverage: 78% 2 Range: 107 to 387  |  Coverage: 58% 3 Range: 5 to 106  |  Coverage: 21% 4
Number of amino acids : 478
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Gln-synt_NPF0395117-98
Gln-synt_CPF00120105-387
Mtb Structural Proteome models
Model Number1
Model nameRv2220_2bvc_A
Template2BVC    APDBCREDO
Template coverage4_478
Template Identity(%)100.0
Model coverage(%)99.2
Normalized DOPE score-1.406

Model Number2
Model nameRv2220
Template2BVC    APDBCREDO
Template coverage4_478
Template Identity(%)100.0
Model coverage(%)99.2
Normalized DOPE score-1.137

Structure Models from Chopin
Model Number1
Profiled.128.1.1, d.15.9.1 - 3.10.20.70, 3.30.590.10
Click for model details
zscore89.03
Residue begin4
Residue end478
Model Number2
Profiled.128.1.1
Click for model details
zscore73.17
Residue begin105
Residue end478
Model Number3
Profile3.30.590.10
Click for model details
zscore54.29
Residue begin107
Residue end387
Model Number4
Profiled.15.9.1
Click for model details
zscore25.18
Residue begin5
Residue end106
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2220Gene nameConfidence Score
Rv3859cgltB0.991
Rv3859cgltB0.991
Rv3859cgltB0.991
Rv3859cgltB0.991
Rv2221cglnE0.985
Rv2221cglnE0.985
Rv3858cgltD0.982
Rv3858cgltD0.982
Rv3858cgltD0.982
Rv2919cglnB0.98
Rv1383carA0.976
Rv1383carA0.976
Rv0808purF0.972
Rv0808purF0.972
Rv3436cglmS0.97
Rv3436cglmS0.97
Rv2391sirA0.969
Rv2391sirA0.969
Rv2211cgcvT0.965
Rv2211cgcvT0.965
Rv2201asnB0.959
Rv2201asnB0.959
Rv0252nirB0.951
Rv0252nirB0.951
Rv0252nirB0.951
Rv0252nirB0.951
Rv0252nirB0.951
Rv2476cgdh0.948
Rv2992cgltS0.945
Rv1538cansA0.941
Rv2920camt0.941
Rv1384carB0.938
Rv1384carB0.938
Rv1384carB0.938
Rv1384carB0.938
Rv3432cgadB0.932
Rv0075Rv00750.923
Rv0253nirD0.92
Rv2294Rv22940.91
Rv1897cRv1897c0.904
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
adenosine diphosphatePubChem0.995427.201
phosphatePubChem0.99196.9872
citratePubChem0.983192.124
glutamatePubChem0.98147.129
ammoniaPubChem0.97617.0305
manganesePubChem0.96454.938
polyglutaminePubChem0.956146.145
adenosine monophosphatePubChem0.952347.221
magnesiumPubChem0.90724.305
adenosine triphosphatePubChem0.904507.181
chloridePubChem0.935.453
PEG400PubChem0.9238.278
protiumPubChem0.92.01576
L-methionine-S-sulfoximine phosphatePubChem0.9260.205
glutaminPubChem0.9146.145
1AzPubChem0.9424.281
hydron diphosphatePubChem0.9391.981
deuteriumPubChem0.92.01588
H(+)PubChem0.92.01588
methionine sulfoximinePubChem0.774180.225
glufosinatePubChem0.767181.127
L-methionine sulfoximinePubChem0.759180.225