Rv2221c

Tuberculist information
Gene nameglnE
Protein functionGlutamate-ammonia-ligase adenylyltransferase GlnE (glutamine-synthetase adenylyltransferase)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)2489.37
Molecular mass(da)109106
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 994
	  		  	1    VVVTKLATQRPKLPSVGRLGLVDPPAGERLAQLGWDRHEDQAHVDLLWSLSRAPDADAAL   60
			  	61   RALIRLSENPDTGWDELNAALLRERSLRGRLFSVLGSSLALGDHLVAHPQSWKLLRGKVT  120
			  	121  LPSHDQLQRSFVECVEESEGMPGSLVHRLRTQYRDYVLMLAALDLAATVEDEPVLPFTVV  180
			  	181  AARLADAADAALAAALRVAEASVCGEHPPPRLAVIAMGKCGARELNYVSDVDVIFVAERS  240
			  	241  DPRNARVASEMMRVASAAFFEVDAALRPEGRNGELVRTLESHIAYYQRWAKTWEFQALLK  300
			  	301  ARPVVGDAELGERYLTALMPMVWRACEREDFVVEVQAMRRRVEQLVPADVRGRELKLGSG  360
			  	361  GLRDVEFAVQLLQLVHARSDESLRVASTVDALAALGEGGYIGREDAANMTASYEFLRLLE  420
			  	421  HRLQLQRLKRTHLLPDPEDEEAVRWLARAAHIRPDGRNDAAGVLREELKKQNVRVSKLHT  480
			  	481  KLFYQPLLESIGPTGLEIAHGMTLEAAGRRLAALGYEGPQTALKHMSALVNQSGRRGRVQ  540
			  	541  SVLLPRLLDWMSYAPDPDGGLLAYRRLSEALATESWYLATLRDKPAVAKRLMHVLGTSAY  600
			  	601  VPDLLMRAPRVIQQYEDGPAGPKLLETEPAAVARALIASASRYPDPERAIAGARTLRRRE  660
			  	661  LARIGSADLLGLLEVTEVCRALTSVWVAVLQAALDVMIRASLPDDDRAPAAIAVIGMGRL  720
			  	721  GGAELGYGSDADVMFVCEPATGVDDARAVKWSTSIAERVRALLGTPSVDPPLELDANLRP  780
			  	781  EGRNGPLVRTLGSYAAYYEQWAQPWEIQALLRAHAVAGDAELGQRFLRMVDKTRYPPDGV  840
			  	841  SADSVREIRRIKARIESERLPRGADPNTHTKLGRGGLADIEWTVQLLQLQHAHQVPALHN  900
			  	901  TSTLQSLDVIAAADLVPAADVELLRQAWLTATRARNALVLVRGKPTDQLPGPGRQLNAVA  960
			  	961  VAAGWRNDDGGEFLDNYLRVTRRAKAVVRKVFGS

Known structures in the PDB
No Known structures
1 100 199 298 397 496 595 694 793 892 991 Range: 88 to 317  |  Coverage: 23% GlnE Range: 335 to 483  |  Coverage: 14% GlnD_UR_UTase Range: 588 to 829  |  Coverage: 24% GlnE Range: 849 to 992  |  Coverage: 14% GlnD_UR_UTase Range: 57 to 483  |  Coverage: 42% 1 Range: 88 to 317  |  Coverage: 23% 1 Range: 588 to 817  |  Coverage: 23% 2 Range: 1 to 149  |  Coverage: 14% 3 Range: 335 to 483  |  Coverage: 14% 4 Range: 849 to 997  |  Coverage: 14% 5
Number of amino acids : 994
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
GlnEPF0371088-317
GlnD_UR_UTasePF08335335-483
GlnEPF03710588-829
GlnD_UR_UTasePF08335849-992
Mtb Structural Proteome models
Model Number1
Model nameRv2221c
Template1V4A    APDBCREDO
Template coverage5_436
Template Identity(%)25.7
Model coverage(%)42.9
Normalized DOPE score-0.52

Structure Models from Chopin
Model Number1
Profiled.218.1.9
Click for model details
zscore18.22
Residue begin88
Residue end317
Model Number2
Profiled.218.1.9
Click for model details
zscore18.22
Residue begin588
Residue end817
Model Number3
Profilea.24.16.4
Click for model details
zscore14.86
Residue begin1
Residue end149
Model Number4
Profilea.24.16.4
Click for model details
zscore14.86
Residue begin335
Residue end483
Model Number5
Profilea.24.16.4
Click for model details
zscore14.86
Residue begin849
Residue end997
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2221cGene nameConfidence Score
Rv2220glnA10.985
Rv2220glnA10.985
Rv2222cglnA20.972
Rv2222cglnA20.972
Rv2918cglnD0.942
Rv2918cglnD0.942
Rv2918cglnD0.942
Rv2919cglnB0.937
Rv2860cglnA40.915
Rv2860cglnA40.915
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
No high confidence interactions