Rv2860c

Tuberculist information
Gene nameglnA4
Protein functionProbable glutamine synthetase GlnA4 (glutamine synthase) (GS-II)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)3171.63
Molecular mass(da)49715.4
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 457
	  		  	1    VTGPGSPPLAWTELERLVAAGDVDTVIVAFTDMQGRLAGKRISGRHFVDDIATRGVECCS   60
			  	61   YLLAVDVDLNTVPGYAMASWDTGYGDMVMTPDLSTLRLIPWLPGTALVIADLVWADGSEV  120
			  	121  AVSPRSILRRQLDRLKARGLVADVATELEFIVFDQPYRQAWASGYRGLTPASDYNIDYAI  180
			  	181  LASSRMEPLLRDIRLGMAGAGLRFEAVKGECNMGQQEIGFRYDEALVTCDNHAIYKNGAK  240
			  	241  EIADQHGKSLTFMAKYDEREGNSCHIHVSLRGTDGSAVFADSNGPHGMSSMFRSFVAGQL  300
			  	301  ATLREFTLCYAPTINSYKRFADSSFAPTALAWGLDNRTCALRVVGHGQNIRVECRVPGGD  360
			  	361  VNQYLAVAALIAGGLYGIERGLQLPEPCVGNAYQGADVERLPVTLADAAVLFEDSALVRE  420
			  	421  AFGEDVVAHYLNNARVELAAFNAAVTDWERIRGFERL

Known structures in the PDB
No Known structures
1 46 91 136 181 226 271 316 361 406 451 Range: 22 to 114  |  Coverage: 20% Gln-synt_N Range: 121 to 374  |  Coverage: 55% Gln-synt_C Range: 10 to 455  |  Coverage: 97% 1 Range: 9 to 456  |  Coverage: 97% 1 Range: 124 to 445  |  Coverage: 70% 2 Range: 10 to 123  |  Coverage: 24% 3
Number of amino acids : 457
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Gln-synt_NPF0395122-114
Gln-synt_CPF00120121-374
Mtb Structural Proteome models
Model Number1
Model nameRv2860c
Template1F52    APDBCREDO
Template coverage1_467
Template Identity(%)25.3
Model coverage(%)97.4
Normalized DOPE score-0.151

Structure Models from Chopin
Model Number1
Profiled.128.1.1, d.15.9.1 - 3.10.20.70, 3.30.590.10
Click for model details
zscore63.23
Residue begin9
Residue end456
Model Number2
Profile3.30.590.10
Click for model details
zscore47.38
Residue begin124
Residue end445
Model Number3
Profiled.15.9.1
Click for model details
zscore14.83
Residue begin10
Residue end123
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2860cGene nameConfidence Score
Rv2859cRv2859c0.972
Rv3704cgshA0.966
Rv2857cRv2857c0.965
Rv3859cgltB0.964
Rv3859cgltB0.964
Rv3859cgltB0.964
Rv3859cgltB0.964
Rv3858cgltD0.938
Rv3858cgltD0.938
Rv3858cgltD0.938
Rv2211cgcvT0.931
Rv2211cgcvT0.931
Rv0252nirB0.93
Rv0252nirB0.93
Rv0252nirB0.93
Rv0252nirB0.93
Rv0252nirB0.93
Rv2476cgdh0.917
Rv2391sirA0.916
Rv2391sirA0.916
Rv2221cglnE0.915
Rv0808purF0.915
Rv2221cglnE0.915
Rv0808purF0.915
Rv3436cglmS0.915
Rv1383carA0.915
Rv3436cglmS0.915
Rv1383carA0.915
Rv2201asnB0.913
Rv2201asnB0.913
Rv3432cgadB0.908
Rv2858caldC0.906
Rv1384carB0.904
Rv1384carB0.904
Rv0253nirD0.904
Rv1384carB0.904
Rv1384carB0.904
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
polyglutaminePubChem0.942146.145
glutamatePubChem0.933147.129
ammoniaPubChem0.90817.0305
glutaminPubChem0.9146.145
phosphatePubChem0.996.9872
protiumPubChem0.92.01576
deuteriumPubChem0.92.01588
H(+)PubChem0.92.01588
adenosine diphosphatePubChem0.9427.201
adenosine triphosphatePubChem0.9507.181