Rv2918c

Tuberculist information
Gene nameglnD
Protein functionProbable [protein-PII] uridylyltransferase GlnD (PII uridylyl- transferase) (uridylyl removing enzyme) (UTASE)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)3228.25
Molecular mass(da)86437.8
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 808
	  		  	1    MEAESPCAASDLAVARRELLSGNHRELDPVGLRQTWLDLHESWLIDKADEIGIADASGFA   60
			  	61   IVGVGGLGRRELLPYSDLDVLLLHDGKPADILRPVADRLWYPLWDANIRLDHSVRTVSEA  120
			  	121  LTIANSDLMAALGMLEARHIAGDQQLSFALIDGVRRQWRNGIRSRMGELVEMTYARWRRC  180
			  	181  GRIAQRAEPDLKLGRGGLRDVQLLDALALAQLIDRHGIGHTDLPAGSLDGAYRTLLDVRT  240
			  	241  ELHRVSGRGRDHLLAQFADEISAALGFGDRFDLARTLSSAGRTIGYHAEAGLRTAANALP  300
			  	301  RRGISALVRRPKRRPLDEGVVEYAGEIVLARDAEPEHDPGLVLRVAAASADTGLPIGAAT  360
			  	361  LSRLAASVPDLPTPWPQEALDDLLVVLSAGPTTVATIEALDRTGLWGRLLPEWEPIRDLP  420
			  	421  PRDVAHKWTVDRHVVETAVHAAPLATRVARPDLLALGALLHDIGKGRGTDHSVLGAELVI  480
			  	481  PVCTRLGLSPPDVRTLSKLVRHHLLLPITATRRDLNDPKTIEAVSEALGGDPQLLEVLHA  540
			  	541  LSEADSKATGPGVWSDWKASLVDDLVRRCRMVMAGESLPQAEPTAPHYLSLAADHGVHVE  600
			  	601  ISPRDGERIDAVIVAPDERGLVSKAAAVLALNSLRVHSASVNVHQGVAITEFVVSPLFGS  660
			  	661  PPAAELVRQQFVGALNGDVDVLGMLQKRDSDAASLVSARAGDVQAGVPVTRTAAPPRILW  720
			  	721  LDTAAPAKLILEVRAMDRAGLLALLAGALEGAGAGIVWAKVNTFGSTAADVFCVTVPAEL  780
			  	781  DARAAVEQHLLEVLGASVDVVVDEPVGD

Known structures in the PDB
No Known structures
1 81 161 241 321 401 481 561 641 721 801 Range: 164 to 292  |  Coverage: 15% GlnD_UR_UTase Range: 430 to 550  |  Coverage: 14% HD Range: 729 to 790  |  Coverage: 7% ACT Range: 2 to 282  |  Coverage: 34% 1 Range: 607 to 803  |  Coverage: 24% 2 Range: 164 to 292  |  Coverage: 15% 1 Range: 430 to 550  |  Coverage: 14% 2 Range: 1 to 64  |  Coverage: 7% 3 Range: 609 to 672  |  Coverage: 7% 4 Range: 729 to 792  |  Coverage: 7% 5
Number of amino acids : 808
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
GlnD_UR_UTasePF08335164-292
HDPF01966430-550
ACTPF01842729-790
Mtb Structural Proteome models
Model Number1
Model nameRv2918c
Template1V4A    APDBCREDO
Template coverage79_426
Template Identity(%)17.4
Model coverage(%)34.7
Normalized DOPE score0.546

Model Number2
Model nameRv2918c.2
Template1U8S    APDBCREDO
Template coverage5_176
Template Identity(%)12.2
Model coverage(%)24.3
Normalized DOPE score1.229

Structure Models from Chopin
Model Number1
Profilea.24.16.4
Click for model details
zscore6.31
Residue begin164
Residue end292
Model Number2
Profilea.211.1.5
Click for model details
zscore5.36
Residue begin430
Residue end550
Model Number3
Profiled.58.18.7 - 3.30.70.260
Click for model details
zscore4.92
Residue begin1
Residue end64
Model Number4
Profiled.58.18.7 - 3.30.70.260
Click for model details
zscore4.92
Residue begin609
Residue end672
Model Number5
Profiled.58.18.7 - 3.30.70.260
Click for model details
zscore4.92
Residue begin729
Residue end792
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2918cGene nameConfidence Score
Rv2919cglnB0.998
Rv2221cglnE0.942
Rv2221cglnE0.942
Rv2920camt0.932
Potential ligand/drug binding sites
Protein ModelPocket NumberDrug Binding Site PMIN ScorePvalue PMINPMAX ScorePvalue PMAX
Rv2918c.214dta_ADN_A_401PDBCREDO0.6070.1710.5800.003
Rv2918c.212uxp_CLM_A_1211PDBCREDO0.5420.2550.5420.006
Rv2918c.211sn0_T44_C_601PDBCREDO0.5630.2260.5380.006
Rv2918c.212uxp_CLM_B_1211PDBCREDO0.5370.2620.5370.006
Rv2918c.211uay_ADN_A_1001PDBCREDO0.5360.2640.5360.006
Rv2918c.214dt8_ADN_A_401PDBCREDO0.5510.2430.5260.007
Rv2918c.213r9c_ECL_A_452PDBCREDO0.6270.1480.5260.007
Rv2918c.213s20_CER_B_1PDBCREDO0.5770.2070.5250.007
Rv2918c.211ie4_T44_A_128PDBCREDO0.6480.1260.5210.008
Rv2918c.211sn5_T3_D_602PDBCREDO0.5440.2520.5200.008
Rv2918c.212x7h_PFN_A_1372PDBCREDO0.5400.2580.5160.009
Rv2918c.212jih_097_A_1001PDBCREDO0.6080.1700.5010.011
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
No high confidence interactions