Rv3436c

Tuberculist information
Gene nameglmS
Protein functionProbable glucosamine--fructose-6-phosphate aminotransferase [isomerizing] GlmS (hexosephosphate aminotransferase) (D-fructose-6-phosphate amidotransferase) (GFAT) (L-glutamine-D-fructose-6-phosphate amidotransferase) (glucosamine-6-phosphate synthase)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)3855.01
Molecular mass(da)67539.7
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 624
	  		  	1    VCGIVGYVGRRPAYVVVMDALRRMEYRGYDSSGIALVDGGTLTVRRRAGRLANLEEAVAE   60
			  	61   MPSTALSGTTGLGHTRWATHGRPTDRNAHPHRDAAGKIAVVHNGIIENFAVLRRELETAG  120
			  	121  VEFASDTDTEVAAHLVARAYRHGETADDFVGSVLAVLRRLEGHFTLVFANADDPGTLVAA  180
			  	181  RRSTPLVLGIGDNEMFVGSDVAAFIEHTREAVELGQDQAVVITADGYRISDFDGNDGLQA  240
			  	241  GRDFRPFHIDWDLAAAEKGGYEYFMLKEIAEQPAAVADTLLGHFVGGRIVLDEQRLSDQE  300
			  	301  LREIDKVFVVACGTAYHSGLLAKYAIEHWTRLPVEVELASEFRYRDPVLDRSTLVVAISQ  360
			  	361  SGETADTLEAVRHAKEQKAKVLAICNTNGSQIPRECDAVLYTRAGPEIGVASTKTFLAQI  420
			  	421  AANYLLGLALAQARGTKYPDEVEREYHELEAMPDLVARVIAATGPVAELAHRFAQSSTVL  480
			  	481  FLGRHVGYPVALEGALKLKELAYMHAEGFAAGELKHGPIALIEDGLPVIVVMPSPKGSAT  540
			  	541  LHAKLLSNIREIQTRGAVTIVIAEEGDETVRPYADHLIEIPAVSTLLQPLLSTIPLQVFA  600
			  	601  ASVARARGYDVDKPRNLAKSVTVE

Known structures in the PDB
No Known structures
1 63 125 187 249 311 373 435 497 559 621 Range: 52 to 200  |  Coverage: 23% GATase_6 Range: 300 to 429  |  Coverage: 20% SIS Range: 472 to 607  |  Coverage: 21% SIS Range: 2 to 624  |  Coverage: 99% 1 Range: 1 to 130  |  Coverage: 20% 1 Range: 1 to 187  |  Coverage: 29% 2 Range: 1 to 130  |  Coverage: 20% 3 Range: 300 to 429  |  Coverage: 20% 4 Range: 472 to 601  |  Coverage: 20% 5
Number of amino acids : 624
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
GATase_6PF1352252-200
SISPF01380300-429
SISPF01380472-607
Mtb Structural Proteome models
Model Number1
Model nameRv3436c
Template2BPL    CPDBCREDO
Template coverage1_608
Template Identity(%)41.6
Model coverage(%)99.7
Normalized DOPE score-0.622

Structure Models from Chopin
Model Number1
Profilec.80.1.1, d.153.1.1 - 3.40.50.10490, 3.60.20.10
Click for model details
zscore38.31
Residue begin1
Residue end130
Model Number2
Profiled.153.1.1 - 3.60.20.10
Click for model details
zscore34.29
Residue begin1
Residue end187
Model Number3
Profilec.80.1.1
Click for model details
zscore27
Residue begin1
Residue end130
Model Number4
Profilec.80.1.1
Click for model details
zscore27
Residue begin300
Residue end429
Model Number5
Profilec.80.1.1
Click for model details
zscore27
Residue begin472
Residue end601
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3436cGene nameConfidence Score
Rv3441cmrsA0.998
Rv3441cmrsA0.998
Rv3441cmrsA0.998
Rv3441cmrsA0.998
Rv1018cglmU0.988
Rv1018cglmU0.988
Rv1383carA0.983
Rv1383carA0.983
Rv3332nagA0.981
Rv2220glnA10.97
Rv2220glnA10.97
Rv0808purF0.969
Rv0808purF0.969
Rv1384carB0.953
Rv1384carB0.953
Rv2925crnc0.953
Rv1384carB0.953
Rv2925crnc0.953
Rv1384carB0.953
Rv2222cglnA20.95
Rv2222cglnA20.95
Rv3859cgltB0.948
Rv3859cgltB0.948
Rv3859cgltB0.948
Rv3859cgltB0.948
Rv3858cgltD0.941
Rv3858cgltD0.941
Rv3858cgltD0.941
Rv3255cmanA0.939
Rv0946cpgi0.933
Rv0993galU0.927
Rv2555calaS0.923
Rv2555calaS0.923
Rv2555calaS0.923
Rv2442crplU0.916
Rv2860cglnA40.915
Rv2860cglnA40.915
Rv3459crpsK0.907
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
glucosamine-6-phosphatePubChem0.997259.151
glutamatePubChem0.987147.129
D-fructose-6-phosphatePubChem0.984260.136
D-fructose 6-phosphatePubChem0.98260.136
fructose 6-phosphatePubChem0.97260.136
glucosamine-1-phosphatePubChem0.969259.151
polyglutaminePubChem0.951146.145
glucose-6-phosphatePubChem0.938260.136
D-glucosamine 6-phosphatePubChem0.938259.151
glutaminPubChem0.9146.145
UDP-GlcNAcPubChem0.844607.354
2-amino-2-deoxy-D-glucitol-6-phosphatePubChem0.844261.167
acetatePubChem0.76559.044
chitinPubChem0.754627.593
2-amino-2-deoxy-D-glucose-6-phosphatePubChem0.754259.151
N-acetylglucosaminePubChem0.743221.208
alpha-D-glucose 6-phosphatePubChem0.738260.136
2-amino-2-deoxy-d-glucitol-6PPubChem0.738261.167
azaserinePubChem0.736173.127
2-amino-2-deoxy-D-glucitolPubChem0.724181.187
6-diazo-5-oxo-L-norleucinePubChem0.715171.154
glucose-6-PPubChem0.702260.136