Rv3332

Tuberculist information
Gene namenagA
Protein functionProbable N-acetylglucosamine-6-phosphate deacetylase NagA (GlcNAc 6-P deacetylase)
Functional category(tuberculist)cell wall and cell processes
Gene location(kb)3718.59
Molecular mass(da)38773
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 383
	  		  	1    VTVLGADAVVIDGRICRPGWVHTADGRILSGGAGAPPMPADAEFPDAIVVPGFVDMHVHG   60
			  	61   GGGASFADGNAADIARAAEFHLRHGTTTTLASLVTAGPAELLSAVGALAEATRDGVVAGI  120
			  	121  HLEGPWLSPARCGAHDHTRMRAPDPAEIESVLAAADGAVRMVTLAPELPGSDAAIRRFRD  180
			  	181  AEVVVAVGHTDATYTQTRHAIDLGATVGTHLFNAMPPLDHRAPGPVLALLCDPRVTVEII  240
			  	241  ADGVHVHPAVVHAVIEAVGPDRVAVVTDAIAAAGCGDGAFRLGTMPIEVESSVARVAGAS  300
			  	301  TLAGSTTTMDQLFRTVAGLGSKSDSAGDVALAAAVQVTSATPARALGLTGVGRLAAGYAA  360
			  	361  NLVVLDRDLRVTAVMVNDDWRVG

Known structures in the PDB
No Known structures
1 39 77 115 153 191 229 267 305 343 381 Range: 48 to 366  |  Coverage: 83% Amidohydro_1 Range: 1 to 383  |  Coverage: 99% 1 Range: 52 to 383  |  Coverage: 86% 1
Number of amino acids : 383
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Amidohydro_1PF0197948-366
Mtb Structural Proteome models
Model Number1
Model nameRv3332
Template1YRR    APDBCREDO
Template coverage1_381
Template Identity(%)30.0
Model coverage(%)99.7
Normalized DOPE score-0.617

Structure Models from Chopin
Model Number1
Profilec.1.9.10
Click for model details
zscore60.35
Residue begin52
Residue end383
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3332Gene nameConfidence Score
Rv3436cglmS0.981
Rv3436cglmS0.981
Rv3441cmrsA0.972
Rv3441cmrsA0.972
Rv3441cmrsA0.972
Rv3441cmrsA0.972
Rv0792cRv0792c0.908
Rv0792cRv0792c0.908
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
glucosamine-6-phosphatePubChem0.991259.151
N-acetyl-d-glucosamine-6-phosphatePubChem0.96301.188
acetatePubChem0.95459.044
D-fructose-6-phosphatePubChem0.935260.136
D-fructose 6-phosphatePubChem0.935260.136
ammoniaPubChem0.91217.0305
hydroxyl radicalsPubChem0.90717.0073
deuteriumPubChem0.92.01588
protiumPubChem0.92.01576
H(+)PubChem0.92.01588
D-glucosamine 6-phosphatePubChem0.9259.151
phosphatePubChem0.7996.9872
Fe(III)PubChem0.77255.845
N-acetylglucosaminePubChem0.753221.208
N-acetylglucosamine 6-phosphatePubChem0.739301.188
zincPubChem0.73465.409