Rv3441c

Tuberculist information
Gene namemrsA
Protein functionProbable phospho-sugar mutase / MrsA protein homolog
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)3860.02
Molecular mass(da)45873.1
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 448
	  		  	1    MGRLFGTDGVRGVANRELTAELALALGAAAARRLSRSGAPGRRVAVLGRDPRASGEMLEA   60
			  	61   AVIAGLTSEGVDALRVGVLPTPAVAYLTGAYDADFGVMISASHNPMPDNGIKIFGPGGHK  120
			  	121  LDDDTEDQIEDLVLGVSRGPGLRPAGAGIGRVIDAEDATERYLRHVAKAATARLDDLAVV  180
			  	181  VDCAHGAASSAAPRAYRAAGARVIAINAEPNGRNINDGCGSTHLDPLRAAVLAHRADLGL  240
			  	241  AHDGDADRCLAVDANGDLVDGDAIMVVLALAMKEAGELACNTLVATVMSNLGLHLAMRSA  300
			  	301  GVTVRTTAVGDRYVLEELRAGDYSLGGEQSGHIVMPALGSTGDGIVTGLRLMTRMVQTGS  360
			  	361  SLSDLASAMRTLPQVLINVEVVDKATAAAAPSVRTAVEQAAAELGDTGRILLRPSGTEPM  420
			  	421  IRVMVEAADEGVAQRLAATVADAVSTAR

Known structures in the PDB
No Known structures
1 45 89 133 177 221 265 309 353 397 441 Range: 2 to 138  |  Coverage: 30% PGM_PMM_I Range: 160 to 256  |  Coverage: 21% PGM_PMM_II Range: 260 to 372  |  Coverage: 25% PGM_PMM_III Range: 376 to 445  |  Coverage: 15% PGM_PMM_IV Range: 1 to 447  |  Coverage: 99% 1 Range: 1 to 448  |  Coverage: 99% 1 Range: 2 to 138  |  Coverage: 30% 2 Range: 376 to 445  |  Coverage: 15% 3 Range: 350 to 448  |  Coverage: 21% 4
Number of amino acids : 448
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
PGM_PMM_IPF028782-138
PGM_PMM_IIPF02879160-256
PGM_PMM_IIIPF02880260-372
PGM_PMM_IVPF00408376-445
Mtb Structural Proteome models
Model Number1
Model nameRv3441c
Template1WQA    APDBCREDO
Template coverage1_453
Template Identity(%)33.8
Model coverage(%)99.6
Normalized DOPE score-0.288

Structure Models from Chopin
Model Number1
Profile3.30.310.50, 3.40.120.10
Click for model details
zscore55.29
Residue begin1
Residue end448
Model Number2
Profile3.40.120.10
Click for model details
zscore22.5
Residue begin2
Residue end138
Model Number3
Profile3.30.310.50
Click for model details
zscore12.26
Residue begin376
Residue end445
Model Number4
Profile3.30.310.50
Click for model details
zscore8.26
Residue begin350
Residue end448
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3441cGene nameConfidence Score
Rv1018cglmU0.999
Rv1018cglmU0.999
Rv3436cglmS0.998
Rv3436cglmS0.998
Rv0993galU0.994
Rv3332nagA0.972
Rv3608cfolP10.938
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
glucosamine-6-phosphatePubChem0.979259.151
glucosamine-1-phosphatePubChem0.979259.151
glucose-1-phosphatePubChem0.959260.136
glucose-6-phosphatePubChem0.95260.136
N-acetylglucosamine-1-phosphatePubChem0.933301.188
phosphatePubChem0.91496.9872
acetyl-CoAPubChem0.913809.571
glutamatePubChem0.9147.129
H(+)PubChem0.92.01588
pyrophosphatePubChem0.9177.975
D-glucosamine 6-phosphatePubChem0.9259.151
polyglutaminePubChem0.9146.145
UDP-GlcPubChem0.9566.302
uridine triphosphatePubChem0.9484.141
deuteriumPubChem0.92.01588
glucose-6-PPubChem0.9260.136
coenzyme APubChem0.9767.534
beta-glucanPubChem0.9504.437
maltotetraosePubChem0.9666.578
glutaminPubChem0.9146.145
D-fructose-6-phosphatePubChem0.9260.136
D-fructose 6-phosphatePubChem0.9260.136
Co-APubChem0.9767.534
UDP-glucosePubChem0.9566.302
protiumPubChem0.92.01576
alpha-D-glucose 6-phosphatePubChem0.9260.136
mannanPubChem0.9666.578
maltotriosePubChem0.9504.437
acetyl coenzyme-APubChem0.9809.571
N-acetyl-alpha-D-glucosamine 1-phosphatePubChem0.9301.188