Rv1595

Tuberculist information
Gene namenadB
Protein functionProbable L-aspartate oxidase NadB
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)1795.81
Molecular mass(da)53784.8
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 527
	  		  	1    MAGPAWRDAADVVVIGTGVAGLAAALAADRAGRSVVVLSKAAQTHVTATHYAQGGIAVVL   60
			  	61   PDNDDSVDAHVADTLAAGAGLCDPDAVYSIVADGYRAVTDLVGAGARLDESVPGRWALTR  120
			  	121  EGGHSRRRIVHAGGDATGAEVQRALQDAAGMLDIRTGHVALRVLHDGTAVTGLLVVRPDG  180
			  	181  CGIISAPSVILATGGLGHLYSATTNPAGSTGDGIALGLWAGVAVSDLEFIQFHPTMLFAG  240
			  	241  RAGGRRPLITEAIRGEGAILVDRQGNSITAGVHPMGDLAPRDVVAAAIDARLKATGDPCV  300
			  	301  YLDARGIEGFASRFPTVTASCRAAGIDPVRQPIPVVPGAHYSCGGIVTDVYGQTELLGLY  360
			  	361  AAGEVARTGLHGANRLASNSLLEGLVVGGRAGKAAAAHAAAAGRSRATSSATWPEPISYT  420
			  	421  ALDRGDLQRAMSRDASMYRAAAGLHRLCDSLSGAQVRDVACRRDFEDVALTLVAQSVTAA  480
			  	481  ALARTESRGCHHRAEYPCTVPEQARSIVVRGADDANAVCVQALVAVC

Known structures in the PDB
No Known structures
1 53 105 157 209 261 313 365 417 469 521 Range: 11 to 381  |  Coverage: 70% FAD_binding_2 Range: 424 to 523  |  Coverage: 18% Succ_DH_flav_C Range: 10 to 499  |  Coverage: 92% 1 Range: 1 to 527  |  Coverage: 99% 1 Range: 226 to 346  |  Coverage: 22% 2 Range: 424 to 523  |  Coverage: 18% 3 Range: 393 to 501  |  Coverage: 20% 4 Range: 230 to 394  |  Coverage: 31% 5 Range: 8 to 218  |  Coverage: 39% 6
Number of amino acids : 527
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
FAD_binding_2PF0089011-381
Succ_DH_flav_CPF02910424-523
Mtb Structural Proteome models
Model Number1
Model nameRv1595
Template1KF6    APDBCREDO
Template coverage5_540
Template Identity(%)37.6
Model coverage(%)92.8
Normalized DOPE score0.09

Structure Models from Chopin
Model Number1
Profile1.20.58.100, 3.50.50.60, 3.90.700.10, 4.10.80.40
Click for model details
zscore70.5
Residue begin1
Residue end527
Model Number2
Profiled.168.1.1
Click for model details
zscore15.69
Residue begin226
Residue end346
Model Number3
Profilea.7.3.1
Click for model details
zscore15.28
Residue begin424
Residue end523
Model Number4
Profile1.20.58.100
Click for model details
zscore14.78
Residue begin393
Residue end501
Model Number5
Profile3.90.700.10
Click for model details
zscore12.41
Residue begin230
Residue end394
Model Number6
Profilec.3.1.7
Click for model details
zscore8.26
Residue begin8
Residue end218
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1595Gene nameConfidence Score
Rv1594nadA0.999
Rv1596nadC0.999
Rv1596nadC0.999
Rv0357cpurA0.958
Rv3601cpanD0.955
Rv2421cnadD0.949
Rv1380pyrB0.928
Rv1380pyrB0.928
Rv0337caspC0.911
Rv0896gltA20.911
Rv1538cansA0.906
Rv2201asnB0.901
Rv2201asnB0.901
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
DrugBank IDDrug Name
DB00730DrugBankThiabendazole
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
iminoaspartatePubChem0.982131.087
quinolinic acidPubChem0.969167.119
dihydroxyacetone phosphatePubChem0.968170.058
aspartatePubChem0.942133.103
oxaloacetatePubChem0.911132.072
glutamatePubChem0.902147.129
molecular oxygenPubChem0.90131.9988
alpha-ketoglutaratePubChem0.9146.098
deuteriumPubChem0.92.01588
potassium aspartatePubChem0.9133.103
protiumPubChem0.92.01576
phosphatePubChem0.996.9872
hydrogen peroxidePubChem0.934.0147
H(+)PubChem0.92.01588
hydroxyl radicalsPubChem0.917.0073