Rv2421c

Tuberculist information
Gene namenadD
Protein functionProbable nicotinate-nucleotide adenylyltransferase NadD (deamido-NAD(+) pyrophosphorylase) (deamido-NAD(+) diphosphorylase) (nicotinate mononucleotide adenylyltransferase) (NAMN adenylyltransferase)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)2718.17
Molecular mass(da)23053
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 211
	  		  	1    MGGTFDPIHYGHLVAASEVADLFDLDEVVFVPSGQPWQKGRQVSAAEHRYLMTVIATASN   60
			  	61   PRFSVSRVDIDRGGPTYTKDTLADLHALHPDSELYFTTGADALASIMSWQGWEELFELAR  120
			  	121  FVGVSRPGYELRNEHITSLLGQLAKDALTLVEIPALAISSTDCRQRAEQSRPLWYLMPDG  180
			  	181  VVQYVSKCRLYCGACDAGARSTTSLAAGNGL

Known structures in the PDB
No Known structures
1 22 43 64 85 106 127 148 169 190 211 Range: 1 to 166  |  Coverage: 78% CTP_transf_2 Range: 2 to 194  |  Coverage: 90% 1 Range: 1 to 199  |  Coverage: 93% 1
Number of amino acids : 211
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
CTP_transf_2PF014671-166
Mtb Structural Proteome models
Model Number1
Model nameRv2421c
Template1YUM    APDBCREDO
Template coverage9_213
Template Identity(%)31.6
Model coverage(%)91.0
Normalized DOPE score-0.54

Structure Models from Chopin
Model Number1
Profilec.26.1.3 - 3.40.50.620
Click for model details
zscore24.42
Residue begin1
Residue end199
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2421cGene nameConfidence Score
Rv2420cRv2420c0.993
Rv1596nadC0.991
Rv1596nadC0.991
Rv0573cpncB20.989
Rv1330cpncB10.985
Rv2438cnadE0.951
Rv2438cnadE0.951
Rv1595nadB0.949
Rv1595nadB0.949
Rv1695ppnK0.933
Rv2713sthA0.902
Rv2713sthA0.902
Rv2713sthA0.902
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
nicotinic acid adenine dinucleotidePubChem0.993665.418
nicotinic acid mononucleotidePubChem0.992336.212
nicotinate mononucleotidePubChem0.991335.204
NAD+PubChem0.984663.425
nicotinate adenine dinucleotidePubChem0.967665.418
adenosine triphosphatePubChem0.961507.181
nicotinamide nucleotidePubChem0.958335.227
H(+)PubChem0.9392.01588
deuteriumPubChem0.9372.01588
pyrophosphatePubChem0.932177.975
adenosine monophosphatePubChem0.92347.221
quinolinic acidPubChem0.9167.119
glutaminPubChem0.9146.145
carbon dioxidePubChem0.944.0095
glutamatePubChem0.9147.129
hydroxyl radicalsPubChem0.917.0073
polyglutaminePubChem0.9146.145
phosphoribosylpyrophosphatePubChem0.9390.07
protiumPubChem0.92.01576
ammoniaPubChem0.917.0305
glycerolPubChem0.80692.0938
1-[(2R,3R,4R,5R)-5-[[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxypPubChem0.796665.418
citratePubChem0.795192.124
calciumPubChem0.7840.078
magnesiumPubChem0.77424.305