Rv2713

Tuberculist information
Gene namesthA
Protein functionProbable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleotide transhydrogenase)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)3025.44
Molecular mass(da)50754
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 468
	  		  	1    MREYDIVVIGSGPGGQKAAIASAKLGKSVAIVERGRMLGGVCVNTGTIPSKTLREAVLYL   60
			  	61   TGMNQRELYGASYRVKDRITPADLLARTQHVIGKEVDVVRNQLMRNRVDLIVGHGRFIDP  120
			  	121  HTILVEDQARREKTTVTGDYIIIATGTRPARPSGVEFDEERVLDSDGILDLKSLPSSMVV  180
			  	181  VGAGVIGIEYASMFAALGTKVTVVEKRDNMLDFCDPEVVEALKFHLRDLAVTFRFGEEVT  240
			  	241  AVDVGSAGTVTTLASGKQIPAETVMYSAGRQGQTDHLDLHNAGLEVQGRGRIFVDDRFQT  300
			  	301  KVDHIYAVGDVIGFPALAATSMEQGRLAAYHAFGEPTDGITELQPIGIYSIPEVSYVGAT  360
			  	361  EVELTKSSIPYEVGVARYRELARGQIAGDSYGMLKLLVSTEDLKLLGVHIFGTSATEMVH  420
			  	421  IGQAVMGCGGSVEYLVDAVFNYPTFSEAYKNAALDVMNKMRALNQFRR

Known structures in the PDB
No Known structures
1 47 93 139 185 231 277 323 369 415 461 Range: 5 to 316  |  Coverage: 66% Pyr_redox_2 Range: 177 to 257  |  Coverage: 17% Pyr_redox Range: 344 to 453  |  Coverage: 23% Pyr_redox_dim Range: 2 to 456  |  Coverage: 97% 1 Range: 1 to 468  |  Coverage: 99% 1 Range: 314 to 468  |  Coverage: 32% 2 Range: 130 to 300  |  Coverage: 36% 3 Range: 344 to 453  |  Coverage: 23% 4
Number of amino acids : 468
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Pyr_redox_2PF079925-316
Pyr_redoxPF00070177-257
Pyr_redox_dimPF02852344-453
Mtb Structural Proteome models
Model Number1
Model nameRv2713
Template3LAD    APDBCREDO
Template coverage2_464
Template Identity(%)33.0
Model coverage(%)97.0
Normalized DOPE score-0.429

Structure Models from Chopin
Model Number1
Profilec.3.1.5, d.87.1.1
Click for model details
zscore79.9
Residue begin1
Residue end468
Model Number2
Profile3.30.390.30
Click for model details
zscore13.67
Residue begin314
Residue end468
Model Number3
Profilec.3.1.5
Click for model details
zscore12.15
Residue begin130
Residue end300
Model Number4
Profiled.87.1.1
Click for model details
zscore11.79
Residue begin344
Residue end453
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2713Gene nameConfidence Score
Rv2215dlaT0.957
Rv2215dlaT0.957
Rv2215dlaT0.957
Rv2496cbkdB0.938
Rv2496cbkdB0.938
Rv1248cRv1248c0.914
Rv1248cRv1248c0.914
Rv1248cRv1248c0.914
Rv2495cbkdC0.912
Rv2495cbkdC0.912
Rv2495cbkdC0.912
Rv2421cnadD0.902
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
NAD+PubChem0.959663.425
NADPPubChem0.945744.413
flavin adenine dinucleotidePubChem0.773785.55