Rv2496c

Tuberculist information
Gene namebkdB
Protein functionProbable branched-chain keto acid dehydrogenase E1 component, beta subunit BkdB
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)2809.94
Molecular mass(da)38064.3
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 348
	  		  	1    MTQIADRPARPDETLAVAVSDITQSLTMVQAINRALYDAMAADERVLVFGEDVAVEGGVF   60
			  	61   RVTEGLADTFGADRCFDTPLAESAIIGIAVGLALRGFVPVPEIQFDGFSYPAFDQVVSHL  120
			  	121  AKYRTRTRGEVDMPVTVRIPSFGGIGAAEHHSDSTESYWVHTAGLKVVVPSTPGDAYWLL  180
			  	181  RHAIACPDPVMYLEPKRRYHGRGMVDTSRPEPPIGHAMVRRSGTDVTVVTYGNLVSTALS  240
			  	241  SADTAEQQHDWSLEVIDLRSLAPLDFDTIAASIQRTGRCVVMHEGPRSLGYGAGLAARIQ  300
			  	301  EEMFYQLEAPVLRACGFDTPYPPARLEKLWLPGPDRLLDCVERVLRQP

Known structures in the PDB
No Known structures
1 35 69 103 137 171 205 239 273 307 341 Range: 24 to 201  |  Coverage: 50% Transket_pyr Range: 215 to 337  |  Coverage: 35% Transketolase_C Range: 24 to 346  |  Coverage: 92% 1 Range: 24 to 201  |  Coverage: 50% 1
Number of amino acids : 348
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Transket_pyrPF0277924-201
Transketolase_CPF02780215-337
Mtb Structural Proteome models
Model Number1
Model nameRv2496c
Template1UMD    BPDBCREDO
Template coverage2_323
Template Identity(%)47.5
Model coverage(%)92.5
Normalized DOPE score-1.24

Structure Models from Chopin
Model Number1
Profilec.36.1.7
Click for model details
zscore41.18
Residue begin24
Residue end201
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2496cGene nameConfidence Score
Rv2215dlaT0.999
Rv2497cbkdA0.999
Rv2495cbkdC0.999
Rv2215dlaT0.999
Rv2495cbkdC0.999
Rv2215dlaT0.999
Rv2495cbkdC0.999
Rv0843Rv08430.999
Rv0462lpdC0.998
Rv0462lpdC0.998
Rv0462lpdC0.998
Rv1617pykA0.986
Rv1617pykA0.986
Rv3303clpdA0.986
Rv3303clpdA0.986
Rv3303clpdA0.986
Rv0363cfba0.984
Rv2967cpca0.967
Rv2967cpca0.967
Rv2967cpca0.967
Rv2967cpca0.967
Rv2967cpca0.967
Rv2967cpca0.967
Rv1449ctkt0.963
Rv1449ctkt0.963
Rv1449ctkt0.963
Rv0794cRv0794c0.962
Rv0794cRv0794c0.962
Rv0794cRv0794c0.962
Rv3002cilvN0.951
Rv3002cilvN0.951
Rv3003cilvB10.947
Rv3003cilvB10.947
Rv3003cilvB10.947
Rv1127cppdK0.94
Rv1127cppdK0.94
Rv2713sthA0.938
Rv2713sthA0.938
Rv2713sthA0.938
Rv1023eno0.935
Rv1023eno0.935
Rv2332mez0.933
Rv2332mez0.933
Rv3667acs0.932
Rv3667acs0.932
Rv0752cfadE90.926
Rv0752cfadE90.926
Rv0752cfadE90.926
Rv1872clldD20.92
Rv0694lldD10.907
Rv3470cilvB20.903
Rv2241aceE0.903
Rv3470cilvB20.903
Rv3470cilvB20.903
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
thiamine pyrophosphatePubChem0.986425.314
alpha-ketoisocaproatePubChem0.98130.142
acetyl-CoAPubChem0.961809.571
coenzyme APubChem0.934767.534
isobutyryl-CoAPubChem0.934837.624
isobutyryl coenzyme APubChem0.932837.624
phosphoenolpyruvatePubChem0.92168.042
isovaleryl-CoAPubChem0.915851.651
pyruvic acidPubChem0.91588.0621
2-methylbutyryl-CoAPubChem0.913851.651
lipoamidePubChem0.913205.341
adenosine diphosphatePubChem0.905427.201
adenosine triphosphatePubChem0.903507.181
NAD+PubChem0.902663.425
carbon dioxidePubChem0.90144.0095
DL-lipoamidePubChem0.9205.341
H(+)PubChem0.92.01588
alpha-keto-beta-methylvaleric acidPubChem0.9130.142
Co-APubChem0.9767.534
reduced nicotinamide adenine dinucleotidePubChem0.9665.441
flavin adenine dinucleotidePubChem0.9785.55
3-methylbutyryl-CoAPubChem0.9851.651
protiumPubChem0.92.01576
acetyl coenzyme-APubChem0.9809.571
CHEBI:15477PubChem0.9851.651
C05125PubChem0.9469.367
dihydronicotinamide formycin dinucleotidePubChem0.9665.441
alpha-ketoisovaleratePubChem0.9116.115
deuteriumPubChem0.92.01588
6-S-acetyldihydrolipoamidePubChem0.9249.393
magnesiumPubChem0.79724.305
acetoinPubChem0.72788.1051
selenomethioninePubChem0.724196.106
SeMetPubChem0.724196.106
MagnumPubChem0.716507.987
dihydrolipoamidePubChem0.709207.357