Rv0694

Tuberculist information
Gene namelldD1
Protein functionPossible L-lactate dehydrogenase (cytochrome) LldD1
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)793.335
Molecular mass(da)42129.2
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 396
	  		  	1    VAEAWFETVAIAQQRAKRRLPKSVYSSLIAASEKGITVADNVAAFSELGFAPHVIGATDK   60
			  	61   RDLSTTVMGQEVSLPVIISPTGVQAVDPGGEVAVARAAAARGTVMGLSSFASKPIEEVIA  120
			  	121  ANPKTFFQVYWQGGRDALAERVERARQAGAVGLVVTTDWTFSHGRDWGSPKIPEEMNLKT  180
			  	181  ILRLSPEAITRPRWLWKFAKTLRPPDLRVPNQGRRGEPGPPFFAAYGEWMATPPPTWEDI  240
			  	241  GWLRELWGGPFMLKGVMRVDDAKRAVDAGVSAISVSNHGGNNLDGTPASIRALPAVSAAV  300
			  	301  GDQVEVLLDGGIRRGSDVVKAVALGARAVMIGRAYLWGLAANGQAGVENVLDILRGGIDS  360
			  	361  ALMGLGHASVHDLSPADILVPTGFIRDLGVPSRRDV

Known structures in the PDB
No Known structures
1 40 79 118 157 196 235 274 313 352 391 Range: 16 to 380  |  Coverage: 91% FMN_dh Range: 4 to 384  |  Coverage: 95% 1 Range: 1 to 396  |  Coverage: 99% 1
Number of amino acids : 396
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
FMN_dhPF0107016-380
Mtb Structural Proteome models
Model Number1
Model nameRv0694
Template1GOX    APDBCREDO
Template coverage1_358
Template Identity(%)37.0
Model coverage(%)95.7
Normalized DOPE score-0.279

Structure Models from Chopin
Model Number1
Profilec.1.4.1 - 3.20.20.70
Click for model details
zscore20.62
Residue begin1
Residue end396
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0694Gene nameConfidence Score
Rv3470cilvB20.963
Rv3470cilvB20.963
Rv3470cilvB20.963
Rv0693pqqE0.954
Rv0693pqqE0.954
Rv0693pqqE0.954
Rv1617pykA0.952
Rv1617pykA0.952
Rv2332mez0.941
Rv2332mez0.941
Rv2241aceE0.937
Rv2967cpca0.932
Rv2967cpca0.932
Rv2967cpca0.932
Rv2967cpca0.932
Rv2967cpca0.932
Rv2967cpca0.932
Rv1872clldD20.931
Rv0692Rv06920.924
Rv0695Rv06950.917
Rv1127cppdK0.915
Rv1127cppdK0.915
Rv1905caao0.908
Rv2496cbkdB0.907
Rv2496cbkdB0.907
Rv2497cbkdA0.903
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
pyruvic acidPubChem0.9188.0621