Rv1905c

Tuberculist information
Gene nameaao
Protein functionProbable D-amino acid oxidase Aao
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)2151.43
Molecular mass(da)34076.2
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 320
	  		  	1    VAIGEQQVIVIGAGVSGLTSAICLAEAGWPVRVWAAALPQQTTSAVAGAVWGPRPKEPVA   60
			  	61   KVRGWIEQSLHVFRDLAKDPATGVRMTPALSVGDRIETGAMPPGLELIPDVRPADPADVP  120
			  	121  GGFRAGFHATLPMIDMPQYLDCLTQRLAATGCEIETRPLRSLAEAAEAAPIVINCAGLGA  180
			  	181  RELAGDATVWPRFGQHVVLTNPGLEQLFIERTGGSEWICYFAHPQRVVCGGISIPGRWDP  240
			  	241  TPEPEITERILQRCRRIQPRLAEAAVIETITGLRPDRPSVRVEAEPIGRALCIHNYGHGG  300
			  	301  DGVTLSWGCAREVVNLVGGG

Known structures in the PDB
No Known structures
1 33 65 97 129 161 193 225 257 289 321 Range: 7 to 316  |  Coverage: 96% DAO Range: 6 to 319  |  Coverage: 97% 1 Range: 189 to 279  |  Coverage: 28% 1 Range: 1 to 127  |  Coverage: 39% 2
Number of amino acids : 320
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
DAOPF012667-316
Mtb Structural Proteome models
Model Number1
Model nameRv1905c
Template1AN9    APDBCREDO
Template coverage1_332
Template Identity(%)32.2
Model coverage(%)97.8
Normalized DOPE score-0.876

Structure Models from Chopin
Model Number1
Profiled.16.1.3
Click for model details
zscore9.26
Residue begin189
Residue end279
Model Number2
Profilec.2.1.11
Click for model details
zscore4.97
Residue begin1
Residue end127
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1905cGene nameConfidence Score
Rv1832gcvB0.917
Rv1832gcvB0.917
Rv1872clldD20.909
Rv0694lldD10.908
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
flavin adenine dinucleotidePubChem0.97785.55
hydrogen peroxidePubChem0.93734.0147
cephalosporin CPubChem0.923414.41
polyglycinePubChem0.91975.0666
ammoniaPubChem0.91517.0305
molecular oxygenPubChem0.9131.9988
glyoxylatePubChem0.90574.0355
hydroxyl radicalsPubChem0.90417.0073
D-serinePubChem0.712105.093