Rv3003c

Tuberculist information
Gene nameilvB1
Protein functionAcetolactate synthase (large subunit) IlvB1 (acetohydroxy-acid synthase)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)3361.13
Molecular mass(da)66090.7
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 618
	  		  	1    VSAPTKPHSPTFKPEPHSAANEPKHPAARPKHVALQQLTGAQAVIRSLEELGVDVIFGIP   60
			  	61   GGAVLPVYDPLFDSKKLRHVLVRHEQGAGHAASGYAHVTGRVGVCMATSGPGATNLVTPL  120
			  	121  ADAQMDSIPVVAITGQVGRGLIGTDAFQEADISGITMPITKHNFLVRSGDDIPRVLAEAF  180
			  	181  HIAASGRPGAVLVDIPKDVLQGQCTFSWPPRMELPGYKPNTKPHSRQVREAAKLIAAARK  240
			  	241  PVLYVGGGVIRGEATEQLRELAELTGIPVVTTLMARGAFPDSHRQNLGMPGMHGTVAAVA  300
			  	301  ALQRSDLLIALGTRFDDRVTGKLDSFAPEAKVIHADIDPAEIGKNRHADVPIVGDVKAVI  360
			  	361  TELIAMLRHHHIPGTIEMADWWAYLNGVRKTYPLSYGPQSDGSLSPEYVIEKLGEIAGPD  420
			  	421  AVFVAGVGQHQMWAAQFIRYEKPRSWLNSGGLGTMGFAIPAAMGAKIALPGTEVWAIDGD  480
			  	481  GCFQMTNQELATCAVEGIPVKVALINNGNLGMVRQWQSLFYAERYSQTDLATHSHRIPDF  540
			  	541  VKLAEALGCVGLRCEREEDVVDVINQARAINDCPVVIDFIVGADAQVWPMVAAGTSNDEI  600
			  	601  QAARGIRPLFDDITEGHA

Known structures in the PDB
No Known structures
1 62 123 184 245 306 367 428 489 550 611 Range: 38 to 207  |  Coverage: 27% TPP_enzyme_N Range: 228 to 363  |  Coverage: 21% TPP_enzyme_M Range: 426 to 579  |  Coverage: 24% TPP_enzyme_C Range: 30 to 607  |  Coverage: 93% 1 Range: 34 to 600  |  Coverage: 91% 1 Range: 426 to 579  |  Coverage: 24% 2 Range: 38 to 207  |  Coverage: 27% 3 Range: 208 to 401  |  Coverage: 31% 4 Range: 387 to 618  |  Coverage: 37% 5 Range: 228 to 363  |  Coverage: 21% 6 Range: 9 to 249  |  Coverage: 38% 7
Number of amino acids : 618
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
TPP_enzyme_NPF0277638-207
TPP_enzyme_MPF00205228-363
TPP_enzyme_CPF02775426-579
Mtb Structural Proteome models
Model Number1
Model nameRv3003c
Template1YBH    APDBCREDO
Template coverage89_667
Template Identity(%)45.8
Model coverage(%)93.4
Normalized DOPE score-0.861

Structure Models from Chopin
Model Number1
Profilec.31.1.3, c.36.1.5, c.36.1.9 - 1.20.5.740, 3.40.50.1220, 3.40.50.970
Click for model details
zscore85.49
Residue begin34
Residue end600
Model Number2
Profilec.36.1.9
Click for model details
zscore29.77
Residue begin426
Residue end579
Model Number3
Profilec.36.1.5
Click for model details
zscore26.48
Residue begin38
Residue end207
Model Number4
Profilec.31.1.3
Click for model details
zscore24.86
Residue begin208
Residue end401
Model Number5
Profilec.36.1.9
Click for model details
zscore22.46
Residue begin387
Residue end618
Model Number6
Profile3.40.50.1220
Click for model details
zscore13.49
Residue begin228
Residue end363
Model Number7
Profilec.36.1.11 - 3.40.50.970
Click for model details
zscore12.94
Residue begin9
Residue end249
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3003cGene nameConfidence Score
Rv3002cilvN0.999
Rv0189cilvD0.999
Rv3002cilvN0.999
Rv1559ilvA0.999
Rv2995cleuB0.999
Rv1559ilvA0.999
Rv3001cilvC0.999
Rv3001cilvC0.999
Rv3710leuA0.998
Rv3710leuA0.998
Rv2210cilvE0.994
Rv2988cleuC0.992
Rv2987cleuD0.98
Rv2241aceE0.957
Rv1617pykA0.956
Rv1617pykA0.956
Rv2496cbkdB0.947
Rv2496cbkdB0.947
Rv2497cbkdA0.935
Rv2967cpca0.928
Rv2967cpca0.928
Rv2967cpca0.928
Rv2967cpca0.928
Rv2967cpca0.928
Rv2967cpca0.928
Rv0843Rv08430.913
Rv2332mez0.913
Rv2332mez0.913
Rv1612trpB0.901
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
DrugBank IDDrug Name
DB00336DrugBankNitrofurazone
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
sulfometuron methylPubChem0.971364.376
alpha-ketobutyratePubChem0.967102.089
CID-21PubChem0.958146.141
CID-22PubChem0.95132.115
thiamine pyrophosphatePubChem0.944425.314
H(+)PubChem0.9232.01588
deuteriumPubChem0.9222.01588
ammoniaPubChem0.91817.0305
L-threoninePubChem0.915119.119
carbon dioxidePubChem0.91544.0095
pyruvic acidPubChem0.90988.0621
NADPPubChem0.905744.413
C06006PubChem0.9146.141
protiumPubChem0.92.01576
flavin adenine dinucleotidePubChem0.9785.55
2,3-dihydroxy-3-methylpentanoic acidPubChem0.9148.157
NADP(H)PubChem0.9745.421
L-allo-threoninePubChem0.9119.119
(S)-2-acetolactatePubChem0.9132.115
C05125PubChem0.9469.367
(2R,3R)-2,3-dihydroxy-3-methylvaleratePubChem0.9148.157
chlorsulfuronPubChem0.868357.773
magnesiumPubChem0.84824.305
metsulfuron-methylPubChem0.839381.364
chlorimuron-ethylPubChem0.828414.821
acetolactatePubChem0.771132.115
tribenuron-methylPubChem0.76395.39
DB01798PubChem0.752206.028
sulfonylureaPubChem0.741182.158
alpha-isopropylmalatePubChem0.729176.167
phosphatePubChem0.7296.9872