Rv0843

Tuberculist information
Gene nameRv0843
Protein functionProbable dehydrogenase
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)939.388
Molecular mass(da)35725.4
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 334
	  		  	1    VTRTSEGLAAFVVDQLEELYRRMWVLRLLDMALEQLRIEGLINGPLQGGFGQEAVSVGAA   60
			  	61   AALGEGDVIITTHRPHAQHVGTDAPLGPVIADMLGATAGDLEGADEDAHIADPRAGLPAA  120
			  	121  IRVVKQSPLLAIGHAYALWLRDTGRVTLCVTQDCDVDADAFNEAADLAAVWQLPVVILVE  180
			  	181  NIRGALSVHLDRYTHEPRVYRRAVAYGMPGVSVDGNDVEAVRDCVANAVVRARAGGGPTL  240
			  	241  VQAITYRTTDFSGSDRGGYRDLAGSEQFLDPLIFARRRLIAAGTTRGRLDEQERAACQQV  300
			  	301  ADAVAFAKARARPNGGGPISRPTSGWHQQPKTRF

Known structures in the PDB
No Known structures
1 34 67 100 133 166 199 232 265 298 331 Range: 20 to 315  |  Coverage: 88% E1_dh Range: 1 to 313  |  Coverage: 93% 1 Range: 1 to 334  |  Coverage: 99% 1
Number of amino acids : 334
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
E1_dhPF0067620-315
Mtb Structural Proteome models
Model Number1
Model nameRv0843
Template1NI4    APDBCREDO
Template coverage14_330
Template Identity(%)26.5
Model coverage(%)93.4
Normalized DOPE score-0.403

Structure Models from Chopin
Model Number1
Profilec.36.1.10
Click for model details
zscore8.97
Residue begin1
Residue end334
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0843Gene nameConfidence Score
Rv2496cbkdB0.999
Rv2496cbkdB0.999
Rv2495cbkdC0.993
Rv2495cbkdC0.993
Rv2495cbkdC0.993
Rv0462lpdC0.98
Rv0462lpdC0.98
Rv0462lpdC0.98
Rv1449ctkt0.978
Rv1449ctkt0.978
Rv1449ctkt0.978
Rv3303clpdA0.946
Rv3303clpdA0.946
Rv3303clpdA0.946
Rv2497cbkdA0.934
Rv1617pykA0.922
Rv1617pykA0.922
Rv0794cRv0794c0.921
Rv0794cRv0794c0.921
Rv0794cRv0794c0.921
Rv1127cppdK0.919
Rv1127cppdK0.919
Rv3003cilvB10.913
Rv3003cilvB10.913
Rv3003cilvB10.913
Rv2967cpca0.904
Rv2967cpca0.904
Rv2967cpca0.904
Rv2967cpca0.904
Rv2967cpca0.904
Rv2967cpca0.904
Rv1872clldD20.903
Rv2332mez0.901
Rv2332mez0.901
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
pyruvic acidPubChem0.90188.0621
C05125PubChem0.9469.367