Rv2495c

Tuberculist information
Gene namebkdC
Protein functionProbable branched-chain keto acid dehydrogenase E2 component BkdC
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)2808.76
Molecular mass(da)41061
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 393
	  		  	1    MSGEDSIRSFPVPDLGEGLQEVTVTCWSVAVGDDVEINQTLCSVETAKAEVEIPSPYAGR   60
			  	61   IVELGGAEGDVLKVGAELVRIDTGPTAVAQPNGEGAVPTLVGYGADTAIETSRRTSRPLA  120
			  	121  APVVRKLAKELAVDLAALQRGSGAGGVITRADVLAAARGGVGAGPDVRPVHGVHARMAEK  180
			  	181  MTLSHKEIPTAKASVEVICAELLRLRDRFVSAAPEITPFALTLRLLVIALKHNVILNSTW  240
			  	241  VDSGEGPQVHVHRGVHLGFGAATERGLLVPVVTDAQDKNTRELASRVAELITGAREGTLT  300
			  	301  PAELRGSTFTVSNFGALGVDDGVPVINHPEAAILGLGAIKPRPVVVGGEVVARPTMTLTC  360
			  	361  VFDHRVVDGAQVAQFMCELRDLIESPETALLDL

Known structures in the PDB
PDB ID3L60
Total residue count250
Number of chains1
MethodX-RAY
Resolution2
1 40 79 118 157 196 235 274 313 352 391 Range: 8 to 81  |  Coverage: 18% Biotin_lipoyl Range: 116 to 155  |  Coverage: 9% E3_binding Range: 163 to 391  |  Coverage: 58% 2-oxoacid_dh Range: 165 to 393  |  Coverage: 58% 1 Range: 7 to 84  |  Coverage: 19% 2 Range: 6 to 87  |  Coverage: 20% 3 Range: 155 to 391  |  Coverage: 60% 4 Range: 150 to 393  |  Coverage: 61% 1 Range: 1 to 103  |  Coverage: 25% 2 Range: 111 to 166  |  Coverage: 13% 3
Number of amino acids : 393
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Biotin_lipoylPF003648-81
E3_bindingPF02817116-155
2-oxoacid_dhPF00198163-391
Mtb Structural Proteome models
Model Number1
Model nameRv2495c_3l60_A
Template3L60    APDBCREDO
Template coverage165_393
Template Identity(%)100.0
Model coverage(%)58.0
Normalized DOPE score-1.693

Model Number2
Model nameRv2495c.2
Template1QJO    APDBCREDO
Template coverage2_77
Template Identity(%)39.5
Model coverage(%)19.6
Normalized DOPE score-1.245

Model Number3
Model nameRv2495c.1
Template1GJX    APDBCREDO
Template coverage1_81
Template Identity(%)30.9
Model coverage(%)20.6
Normalized DOPE score-0.466

Model Number4
Model nameRv2495c
Template1B5S    APDBCREDO
Template coverage184_425
Template Identity(%)36.3
Model coverage(%)60.1
Normalized DOPE score-0.381

Structure Models from Chopin
Model Number1
Profilec.43.1.1 - 3.30.559.10
Click for model details
zscore24.18
Residue begin150
Residue end393
Model Number2
Profileb.84.1.1 - 2.40.50.100
Click for model details
zscore17.73
Residue begin1
Residue end103
Model Number3
Profilea.9.1.1 - 4.10.320.10
Click for model details
zscore13.56
Residue begin111
Residue end166
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2495cGene nameConfidence Score
Rv2497cbkdA0.999
Rv2496cbkdB0.999
Rv2496cbkdB0.999
Rv0462lpdC0.998
Rv0462lpdC0.998
Rv0462lpdC0.998
Rv0843Rv08430.993
Rv3303clpdA0.985
Rv0408pta0.985
Rv0408pta0.985
Rv0408pta0.985
Rv3303clpdA0.985
Rv3303clpdA0.985
Rv1248cRv1248c0.982
Rv1248cRv1248c0.982
Rv1248cRv1248c0.982
Rv2241aceE0.978
Rv0896gltA20.977
Rv0952sucD0.966
Rv0952sucD0.966
Rv0794cRv0794c0.963
Rv0794cRv0794c0.963
Rv0794cRv0794c0.963
Rv3667acs0.957
Rv3667acs0.957
Rv1131prpC0.955
Rv2215dlaT0.953
Rv2215dlaT0.953
Rv2215dlaT0.953
Rv0951sucC0.95
Rv0951sucC0.95
Rv1323fadA40.922
Rv1323fadA40.922
Rv0752cfadE90.92
Rv0752cfadE90.92
Rv0752cfadE90.92
Rv2218lipA0.917
Rv3710leuA0.914
Rv3710leuA0.914
Rv3535chsaG0.913
Rv3535chsaG0.913
Rv2713sthA0.912
Rv2713sthA0.912
Rv2713sthA0.912
Rv0889ccitA0.905
Rv1074cfadA30.904
Rv1074cfadA30.904
Rv0904caccD30.904
Rv0859fadA0.901
Rv0859fadA0.901
Rv3556cfadA60.901
Rv3556cfadA60.901
Rv1837cglcB0.901
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
coenzyme APubChem0.933767.534
acetyl-CoAPubChem0.922809.571
isobutyryl-CoAPubChem0.921837.624
isovaleryl-CoAPubChem0.916851.651
flavin adenine dinucleotidePubChem0.915785.55
Co-APubChem0.914767.534
isobutyryl coenzyme APubChem0.913837.624
alpha-ketoisocaproatePubChem0.912130.142
NAD+PubChem0.91663.425
thiamine pyrophosphatePubChem0.908425.314
2-methylbutyryl-CoAPubChem0.905851.651
carbon dioxidePubChem0.90244.0095
H(+)PubChem0.92.01588
3-methylbutyryl-CoAPubChem0.9851.651
CHEBI:15477PubChem0.9851.651
deuteriumPubChem0.92.01588
alpha-ketoisovaleratePubChem0.9116.115
reduced nicotinamide adenine dinucleotidePubChem0.9665.441
alpha-keto-beta-methylvaleric acidPubChem0.9130.142